CH314564A - Process for the preparation of a penicillin compound - Google Patents
Process for the preparation of a penicillin compoundInfo
- Publication number
- CH314564A CH314564A CH314564DA CH314564A CH 314564 A CH314564 A CH 314564A CH 314564D A CH314564D A CH 314564DA CH 314564 A CH314564 A CH 314564A
- Authority
- CH
- Switzerland
- Prior art keywords
- preparation
- penicillin
- penicillin compound
- compound
- diphenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
<B>Verfahren zur Herstellung einer</B> Penicillinverbindung Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung einer Verbindung des Penicillins mit einem Amin.
Dieses Verfahren ist dadurch gekennzeich net, dass ein Penicillin-G-Salz mit a,ss-Diphenyl- ss-hydroxy-propylamin umgesetzt wird. Die entstehende Verbindung der Formel
EMI0001.0006
besitzt eine antibiotische Wirksamkeit, die sich durch langdauernde Wirkung auszeichnet.
<I>Beispiel</I> Zu 30 g a,f Diphenyl-ss-hydroxy-propyl- amin-hydroch,lorid in 6 ml Wasser wird eine Lösung von 1 g Natriumpenicillin G, gelöst in 4 ml Wasser, zugegeben. Das Öl, welches beim Rühren sich abscheidet, geht beim An reiben in Kristalle über. Diese Kristalle wer den abfiltriert und in einem Vakuumexsikka- tor getrocknet.
<B> Method for producing a penicillin compound The present invention relates to a method for producing a compound of penicillin with an amine.
This process is characterized in that a penicillin G salt is reacted with α, β-diphenyl-β-hydroxypropylamine. The resulting compound of the formula
EMI0001.0006
has an antibiotic effect, which is characterized by a long-lasting effect.
<I> Example </I> A solution of 1 g of sodium penicillin G, dissolved in 4 ml of water, is added to 30 g of a, f diphenyl-ss-hydroxy-propyl-amine-hydroch, loride in 6 ml of water. The oil, which separates out when stirring, turns into crystals when rubbed. These crystals are filtered off and dried in a vacuum desiccator.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US314564XA | 1951-02-16 | 1951-02-16 | |
| CH307479T | 1951-09-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH314564A true CH314564A (en) | 1956-06-15 |
Family
ID=25735283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH314564D CH314564A (en) | 1951-02-16 | 1951-09-05 | Process for the preparation of a penicillin compound |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH314564A (en) |
-
1951
- 1951-09-05 CH CH314564D patent/CH314564A/en unknown
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