CH311082A - Process for the preparation of an isonicotinic acid derivative. - Google Patents

Process for the preparation of an isonicotinic acid derivative.

Info

Publication number
CH311082A
CH311082A CH311082DA CH311082A CH 311082 A CH311082 A CH 311082A CH 311082D A CH311082D A CH 311082DA CH 311082 A CH311082 A CH 311082A
Authority
CH
Switzerland
Prior art keywords
isonicotinic acid
acid derivative
preparation
cyclohexanone
isonicotinyl
Prior art date
Application number
Other languages
German (de)
Inventor
F Hoffmann- Aktiengesellschaft
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CH311082A publication Critical patent/CH311082A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/86—Hydrazides; Thio or imino analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Herstellung eines     Isonicotinsäurederivates.       Gegenstand des vorliegenden Patentes ist  ein     Verfahren    zur Herstellung eines     Isonico-          tinsäurederivates,    welches dadurch gekenn  zeichnet ist, dass     Isonicotinsäur        ehydr        azid    mit       Cyclohexanon    zum     1-Isonicotinyl-2-cyclohexyl-          iden-hydrazin    kondensiert wird. Zweckmässig  wird die Kondensation in einem Verdünnungs  mittel, z. B. Wasser, durchgeführt.  



  Die neue     Verbindung    soll als Heilmittel,  insbesondere bei Tuberkulose, verwendet wer  den.  



       Beispiel:     21 g     Isonicotinsäurehydrazid    werden in  250 cm- Wasser gelöst und sodann mit 15 g       Cyclohexanon    versetzt. Das gebildete Zwei  phasensystem wird bis zur Auflösung des     Cy-          clohexanons    geschüttelt. Daraufhin beginnt    das     1-Isonicotinyl-2-cyclohexyliden-hydrazin     in Form von weissen Nadeln, die bei 167,5 bis  169,5  C     schmelzen,    auszukristallisieren.



  Process for the preparation of an isonicotinic acid derivative. The subject of the present patent is a process for the production of an isonicotinic acid derivative, which is characterized in that isonicotinic acid is condensed with cyclohexanone to give 1-isonicotinyl-2-cyclohexylidene hydrazine. Appropriately, the condensation is medium in a diluent, for. B. water performed.



  The new compound is said to be used as a remedy, particularly for tuberculosis.



       Example: 21 g of isonicotinic acid hydrazide are dissolved in 250 cm water and then 15 g of cyclohexanone are added. The two-phase system formed is shaken until the cyclohexanone dissolves. Then the 1-isonicotinyl-2-cyclohexylidene-hydrazine begins to crystallize out in the form of white needles which melt at 167.5 to 169.5 ° C.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines Isonico- tinsäurederivates, dadurch gekennzeichnet, dass Isonicotinsäiuehydrazid mit Cyclohexa- non zum 1 - Isonicotinyl - 2 - cyclohexyliden- hydrazin kondensiert wird. Die neue Verbindung bildet weisse Nadeln und schmilzt bei 167,5-169,5 C. UI\TTERAI\TSPRUCH Verfahren nach Patentanspruch, dadurch gekernizeichnet, dass die Kondensation in einem Verdünnungsmittel durchgeführt wird. PATENT CLAIM: A process for the production of an isonicotinic acid derivative, characterized in that isonicotinic acid hydrazide is condensed with cyclohexanone to form 1 - isonicotinyl - 2 - cyclohexylidene hydrazine. The new compound forms white needles and melts at 167.5-169.5 C. UI \ TTERAI \ TSPRUCH Process according to patent claim, characterized in that the condensation is carried out in a diluent.
CH311082D 1951-03-17 1952-01-23 Process for the preparation of an isonicotinic acid derivative. CH311082A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US311082XA 1951-03-17 1951-03-17
CH305259T 1952-01-23

Publications (1)

Publication Number Publication Date
CH311082A true CH311082A (en) 1955-11-15

Family

ID=25734913

Family Applications (1)

Application Number Title Priority Date Filing Date
CH311082D CH311082A (en) 1951-03-17 1952-01-23 Process for the preparation of an isonicotinic acid derivative.

Country Status (1)

Country Link
CH (1) CH311082A (en)

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