CH311082A - Process for the preparation of an isonicotinic acid derivative. - Google Patents
Process for the preparation of an isonicotinic acid derivative.Info
- Publication number
- CH311082A CH311082A CH311082DA CH311082A CH 311082 A CH311082 A CH 311082A CH 311082D A CH311082D A CH 311082DA CH 311082 A CH311082 A CH 311082A
- Authority
- CH
- Switzerland
- Prior art keywords
- isonicotinic acid
- acid derivative
- preparation
- cyclohexanone
- isonicotinyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/86—Hydrazides; Thio or imino analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Herstellung eines Isonicotinsäurederivates. Gegenstand des vorliegenden Patentes ist ein Verfahren zur Herstellung eines Isonico- tinsäurederivates, welches dadurch gekenn zeichnet ist, dass Isonicotinsäur ehydr azid mit Cyclohexanon zum 1-Isonicotinyl-2-cyclohexyl- iden-hydrazin kondensiert wird. Zweckmässig wird die Kondensation in einem Verdünnungs mittel, z. B. Wasser, durchgeführt.
Die neue Verbindung soll als Heilmittel, insbesondere bei Tuberkulose, verwendet wer den.
Beispiel: 21 g Isonicotinsäurehydrazid werden in 250 cm- Wasser gelöst und sodann mit 15 g Cyclohexanon versetzt. Das gebildete Zwei phasensystem wird bis zur Auflösung des Cy- clohexanons geschüttelt. Daraufhin beginnt das 1-Isonicotinyl-2-cyclohexyliden-hydrazin in Form von weissen Nadeln, die bei 167,5 bis 169,5 C schmelzen, auszukristallisieren.
Process for the preparation of an isonicotinic acid derivative. The subject of the present patent is a process for the production of an isonicotinic acid derivative, which is characterized in that isonicotinic acid is condensed with cyclohexanone to give 1-isonicotinyl-2-cyclohexylidene hydrazine. Appropriately, the condensation is medium in a diluent, for. B. water performed.
The new compound is said to be used as a remedy, particularly for tuberculosis.
Example: 21 g of isonicotinic acid hydrazide are dissolved in 250 cm water and then 15 g of cyclohexanone are added. The two-phase system formed is shaken until the cyclohexanone dissolves. Then the 1-isonicotinyl-2-cyclohexylidene-hydrazine begins to crystallize out in the form of white needles which melt at 167.5 to 169.5 ° C.
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US311082XA | 1951-03-17 | 1951-03-17 | |
CH305259T | 1952-01-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH311082A true CH311082A (en) | 1955-11-15 |
Family
ID=25734913
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH311082D CH311082A (en) | 1951-03-17 | 1952-01-23 | Process for the preparation of an isonicotinic acid derivative. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH311082A (en) |
-
1952
- 1952-01-23 CH CH311082D patent/CH311082A/en unknown
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