CH298028A - Process for the preparation of a bis-aminoalkoxy-alkane. - Google Patents

Process for the preparation of a bis-aminoalkoxy-alkane.

Info

Publication number
CH298028A
CH298028A CH298028DA CH298028A CH 298028 A CH298028 A CH 298028A CH 298028D A CH298028D A CH 298028DA CH 298028 A CH298028 A CH 298028A
Authority
CH
Switzerland
Prior art keywords
bis
alkane
preparation
ethoxy
aminoalkoxy
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH298028A publication Critical patent/CH298028A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Herstellung eines     Bis-aminoalkoxy-alkans.       Gegenstand vorliegenden Patentes ist ein  Verfahren zur Herstellung eines     Bis-amino-          alkoxy-alkans.    Das Verfahren ist dadurch ge  kennzeichnet, dass man ein     Mol    eines     1,10-Bis-          (r9-lialogen-äthoxy)-dekans    mit zwei     Mol        Pi-          peridin    umsetzt.  



  Die erhaltene neue Verbindung, das     1,10-          Bis-(@-piperidino-äthoxy)-dekan,    siedet unter  0,01 mm Druck bei 197-203 . Sie soll als  Zwischenprodukt zur Herstellung von Arznei  initteln Verwendung finden.  



       Beispiel:     9,7 Teile     1,10-Bis-(@-brom-äthoxy)-dekan     werden in Portionen in 11     TeileIPiperidin    einge  tragen, wobei sich unter Erwärmung die Um  setzung vollzieht. Hierauf. erwärmt man noch  6 Stunden unter     Rückfluss,    darauf zur Entfer  nung des überschüssigen     Piperidins    einige Zeit  im     Vakuum.    Nach dem Erkalten löst man den  Rückstand in verdünnter Salzsäure, schüttelt  die salzsaure Lösung zur Entfernung allfälliger       Neutralteile    mit Äther, klärt sie mit Tierkohle,    filtriert und stellt mit 30      /oiger    Natronlauge  stark alkalisch.

   Die ausgeschiedene Base wird  in Äther aufgenommen, die ätherische Lösung  mit     Kaliumhydroxyd    getrocknet, der Äther ab  gedampft und der Rückstand im Vakuum destil  liert. Das     1,10-Bis-(@-piperidino-äthoxy)-dekan     siedet unter 0,01 mm Druck bei 197-203 .



  Process for the preparation of a bis-aminoalkoxy-alkane. The present patent is a process for the preparation of a bis-amino-alkoxy-alkane. The process is characterized in that one mole of a 1,10-bis- (r9-lialogenoethoxy) decane is reacted with two moles of piperidine.



  The new compound obtained, the 1,10-bis- (@ - piperidino-ethoxy) -dekan, boils under 0.01 mm pressure at 197-203. It should be used as an intermediate product in the manufacture of pharmaceuticals.



       Example: 9.7 parts of 1,10-bis- (@ -bromo-ethoxy) -dekan are added in portions to 11 parts of IPiperidine, and the reaction takes place when heated. On that. it is heated under reflux for a further 6 hours, then for some time in vacuo to remove the excess piperidine. After cooling, the residue is dissolved in dilute hydrochloric acid, the hydrochloric acid solution is shaken with ether to remove any neutral parts, clarified with animal charcoal, filtered and made strongly alkaline with 30% sodium hydroxide solution.

   The precipitated base is taken up in ether, the ethereal solution is dried with potassium hydroxide, the ether is evaporated and the residue is distilled in vacuo. The 1,10-bis- (@ - piperidino-ethoxy) -dekan boils under 0.01 mm pressure at 197-203.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines Bis-amino- alkoxy-alkans, dadurch gekennzeichnet, dass man ein Mol eines 1,10-Bis-(,p-halogen-äthoxy)- dekans mit zwei Mol Piperidin umsetzt. Claim: Process for the preparation of a bis-amino-alkoxy-alkane, characterized in that one mole of a 1,10-bis- (, p-halo-ethoxy) -decane is reacted with two moles of piperidine. Die erhaltene neue Verbindung, das 1,10- Bis-(ss-piperidino-äthoxy)-dekan, siedet unter 0,01 mm Druck bei 197-2030. UNTERANSPRUCH: Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man ein Mol 1,10-Bis-(ss- brom-äthoxy)-dekan mit zwei Nol Piperidin in Gegenwart von überschüssigem Piperidin um setzt. The new compound obtained, the 1,10-bis- (ss-piperidino-ethoxy) -dekan, boils under 0.01 mm pressure at 197-2030. SUBSTANTIAL CLAIM: Process according to patent claim, characterized in that one mole of 1,10-bis- (ss- bromo-ethoxy) decane is reacted with two noles of piperidine in the presence of excess piperidine.
CH298028D 1951-09-20 1951-09-20 Process for the preparation of a bis-aminoalkoxy-alkane. CH298028A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH292945T 1951-09-20
CH298028T 1951-09-20

Publications (1)

Publication Number Publication Date
CH298028A true CH298028A (en) 1954-04-15

Family

ID=25733310

Family Applications (1)

Application Number Title Priority Date Filing Date
CH298028D CH298028A (en) 1951-09-20 1951-09-20 Process for the preparation of a bis-aminoalkoxy-alkane.

Country Status (1)

Country Link
CH (1) CH298028A (en)

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