CH298785A - Process for the preparation of a diquartar diammonium salt. - Google Patents
Process for the preparation of a diquartar diammonium salt.Info
- Publication number
- CH298785A CH298785A CH298785DA CH298785A CH 298785 A CH298785 A CH 298785A CH 298785D A CH298785D A CH 298785DA CH 298785 A CH298785 A CH 298785A
- Authority
- CH
- Switzerland
- Prior art keywords
- dimethylamino
- diquartar
- preparation
- diammonium salt
- bis
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Herstellung eines diquartären Diammoniumsalzes. Gegenstand vorliegenden Patentes ist ein Verfahren zur Herstellung eines diquartären Diammoniumsalzes. Das Verfahren ist da durch gekennzeichnet, dass man 1 Mol Dithio- hydrochinon mit 2 Mol eines y-Dimethylamino- propylhalogenids umsetzt rund auf das erhal tene 1,
4-Bis- (y-dimethylamino-propylmer- capto)-benzol 2 Mol Methyljodid einwirken lässt.
Die erhaltene neue Verbindung, das Di- methojodid des 1,4-Bis-(y-dimetliylamino-pro- pylmercapto)-benzols, schmilzt bei 268 unter Zersetzung. Sie soll als Arzneimittel Verwen dung finden.
<I>Beispiel:</I> 14,2 Teile Dithiohydrochinon und 35 Teile y-Dimethylamino-propylehlorid werden in 100 Vollimteilen abs. Äthanol in Stickstoffatmo sphäre unter Rückfliiss gekocht und innert etwa 1 Stunde eine Lösung von 16,8 Teilen Natrium hydroxyd in 35 Teilen Wasser zugetropft; man kocht noch 14 Stunden -unter Rückfluss. Dann kühlt man ab, setzt 2n-Salzsäure zu bis zur kongosauren Reaktion und distilliert das Äthanol im Vakuum ab.
Der wässerige Rück stand wird mit Äther gewaschen, durch Fil- tration geklärt lind mit 30 % iger Natronlauge stark alkalisch gestellt. Die ausgeschiedene Base wird durch zweimaliges Ausschütteln in Äther aufgenommen. Nach - Trocknen der Ätherlösung mit Natronlauge wird der Äther abdestilliert. Man erhält das 1,4-Bis- (y-di- methylamino-pröpylmercapto)-benzol als Öl.
8 Teile dieser Base werden in 50 Volum- teilen Aceton gelöst, unter gelegentlichem Kühlen allmählich mit 13 Teilen Methyljodid versetzt und anschliessend einige Stunden un ter Rückfluss gekocht. Nach dem Abkühlen saugt man das Di-methojödid des 1,4-Bis-(y- dimethylamino-propylmercapto) -Benzols ab und kristallisiert es aus Methanol. Schmelz punkt 268 unter Zersetzung.
Process for the preparation of a diquartar diammonium salt. The subject of the present patent is a process for the preparation of a diquartar diammonium salt. The process is characterized in that 1 mole of dithio-hydroquinone is reacted with 2 moles of a γ-dimethylaminopropyl halide to give the 1 obtained,
4-bis- (y-dimethylamino-propylmer-capto) -benzene allows 2 mol of methyl iodide to act.
The new compound obtained, the dimethiodide of 1,4-bis (γ-dimethylamino-propylmercapto) -benzene, melts at 268 with decomposition. It should be used as a medicine.
<I> Example: </I> 14.2 parts of dithiohydroquinone and 35 parts of γ-dimethylamino-propyl chloride are in 100 full parts abs. Ethanol is boiled under reflux in a nitrogen atmosphere and a solution of 16.8 parts of sodium hydroxide in 35 parts of water is added dropwise within about 1 hour; it is boiled under reflux for another 14 hours. The mixture is then cooled, 2N hydrochloric acid is added until the Congo acidic reaction occurs and the ethanol is distilled off in vacuo.
The aqueous residue is washed with ether, clarified by filtration and made strongly alkaline with 30% sodium hydroxide solution. The precipitated base is taken up by shaking twice in ether. After the ether solution has been dried with sodium hydroxide solution, the ether is distilled off. The 1,4-bis (γ-dimethylamino-propylmercapto) -benzene is obtained as an oil.
8 parts of this base are dissolved in 50 parts by volume of acetone, 13 parts of methyl iodide are gradually added, with occasional cooling, and the mixture is then refluxed for a few hours. After cooling, the dimethoiodide of 1,4-bis- (γ-dimethylamino-propylmercapto) -benzene is suctioned off and it is crystallized from methanol. Melting point 268 with decomposition.
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH298785T | 1951-07-11 | ||
CH296837T | 1951-07-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH298785A true CH298785A (en) | 1954-05-15 |
Family
ID=25733722
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH298785D CH298785A (en) | 1951-07-11 | 1951-07-11 | Process for the preparation of a diquartar diammonium salt. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH298785A (en) |
-
1951
- 1951-07-11 CH CH298785D patent/CH298785A/en unknown
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CH298785A (en) | Process for the preparation of a diquartar diammonium salt. | |
US1693432A (en) | Therapeutically-active aromatic compound containing mercury in a lateral chain and process of making the same | |
DE921265C (en) | Process for the preparation of aryl-substituted pyrazoline compounds | |
AT254200B (en) | Process for the preparation of disubstituted piperazine compounds | |
DE951214C (en) | Process for the production of N-alkyl-anthranilic acid sulfonic acids and compounds of these sulfonic acids | |
CH298786A (en) | Process for the preparation of a diquartar diammonium salt. | |
CH298784A (en) | Process for the preparation of a diquartar diammonium salt. | |
CH298783A (en) | Process for the preparation of a diquartar diammonium salt. | |
DE730728C (en) | Process for the preparation of an acid of dimethanesulfonic acid imide | |
CH303086A (en) | Process for the production of a coumarin derivative. | |
CH298781A (en) | Process for the preparation of a diquartar diammonium salt. | |
CH298782A (en) | Process for the preparation of a diquartar diammonium salt. | |
CH298787A (en) | Process for the preparation of a diquartar diammonium salt. | |
CH298028A (en) | Process for the preparation of a bis-aminoalkoxy-alkane. | |
DE1253266B (en) | Process for the production of dioxocyclobutene diol | |
CH269082A (en) | Process for the preparation of a diaryl-butenyl-amine. | |
CH548402A (en) | PROCESS FOR THE PREPARATION OF 3-METHOXY-2-SULFANILAMIDOPYRAZINE. | |
CH298030A (en) | Process for the preparation of a bis-aminoalkoxy-alkane. | |
CH281435A (en) | Process for the preparation of a new pyrimidine derivative. | |
DE1107241B (en) | Process for the preparation of dihydrothiophene and dihydrothiapyran-3-carboxylic acid esters | |
DE1005964B (en) | Process for the preparation of new alkoxy mercury compounds | |
CH311468A (en) | Process for the preparation of a derivative of 1-amino-naphthalene-4-sulfonic acid. | |
CH327987A (en) | Process for the production of new basic esters | |
CH167320A (en) | Process for the preparation of 2-ethylmercury mercaptobenzoxazole-5-carboxylic acid sodium. | |
CH217132A (en) | Process for the production of a water-soluble, higher molecular weight, α-substituted benzylamine derivative. |