CH284214A - Process for the production of a new urea derivative. - Google Patents

Process for the production of a new urea derivative.

Info

Publication number
CH284214A
CH284214A CH284214DA CH284214A CH 284214 A CH284214 A CH 284214A CH 284214D A CH284214D A CH 284214DA CH 284214 A CH284214 A CH 284214A
Authority
CH
Switzerland
Prior art keywords
production
urea derivative
new urea
new
benzhydrol
Prior art date
Application number
Other languages
German (de)
Inventor
F Hoffmann- Aktiengesellschaft
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CH284214A publication Critical patent/CH284214A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
    • C07C275/48—Y being a hydrogen or a carbon atom
    • C07C275/50—Y being a hydrogen or an acyclic carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Herstellung eines neuen     Harnstoffderivates.       C     egenstand    der vorliegenden Erfindung  ist ein Verfahren zur Herstellung eines neuen       Harnstoffderivates,    welches dadurch gekenn  zeichnet ist., dass man     Benzhydrol    mit     Mono-          acetvlharnstoff    umsetzt.  



  Der bisher unbekannte     1-Benzhydryl-3-          acetylharnstoff,    welcher farblose Kristalle  vom     Sehmelzpunkt    153 bis 155  C bildet, be  sitzt wertvolle     pharmakologisehe    Eigenschaf  ten und soll als Arzneimittel     verwendet    wer  den.

           Beispiel:       Einer Mischung von 7,4 g     Benzhydrol,    4 g       Acetylharnstoff,    50     em3    Essigsäure und 5     em3          Acetanhydrid    wird eine Mischung von 5     em3     Essigsäure und 0,5     cm3        97o/oiger    Schwefel  säure zugesetzt. Die     ;Mischung    erwärmt sich  spontan, und die     Umsetzung    wird durch Er-         hitzen    am     RückflLisskühler.    während 1.0 Mi  nuten vervollständigt.

   Das Reaktionsgemisch  wird in 1000     ein-    Wasser eingegossen, wor  auf     1-Benzhydryl-3-acetylharnstoff    auskri  stallisiert. Die Verbindung wird     abfiltriert,     mit trockenem, eiskaltem Äthanol gewaschen  und aus 35     em3    Äthanol umkristallisiert, wor  auf sie einen Schmelzpunkt von 153 bis     1.55     C  zeigt.



  Process for the production of a new urea derivative. The subject of the present invention is a process for the preparation of a new urea derivative, which is characterized in that benzhydrol is reacted with monoacetylurea.



  The previously unknown 1-benzhydryl-3-acetylurea, which forms colorless crystals from the melting point 153 to 155 C, has valuable pharmacological properties and is intended to be used as a drug.

           Example: To a mixture of 7.4 g benzhydrol, 4 g acetylurea, 50 em3 acetic acid and 5 em3 acetic anhydride is added a mixture of 5 em3 acetic acid and 0.5 cm3 97% sulfuric acid. The mixture heats up spontaneously and the reaction is initiated by heating on the reflux condenser. Completed within 1.0 minutes.

   The reaction mixture is poured into 1000 a water, where 1-benzhydryl-3-acetylurea auskri crystallized. The compound is filtered off, washed with dry, ice-cold ethanol and recrystallized from 35 em3 ethanol, whereupon it has a melting point of 153 to 1.55 ° C.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines neuen Harnstoffderivates, dadurch gekennzeichnet, dass man Benzhydrol mit Monoaeetylharn- stoff umsetzt. Der bisher -unbekannte 1-Benzhydryl-3-aee- tylharnstoff bildet farblose Kristalle vom Schmelzpunkt 153 bis 1.55 C. PATENT CLAIM: Process for the production of a new urea derivative, characterized in that benzhydrol is reacted with monoethyl urea. The previously unknown 1-benzhydryl-3-aetylurea forms colorless crystals with a melting point of 153 to 1.55 C.
CH284214D 1949-07-12 1950-06-12 Process for the production of a new urea derivative. CH284214A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US284214XA 1949-07-12 1949-07-12

Publications (1)

Publication Number Publication Date
CH284214A true CH284214A (en) 1952-07-15

Family

ID=21843358

Family Applications (1)

Application Number Title Priority Date Filing Date
CH284214D CH284214A (en) 1949-07-12 1950-06-12 Process for the production of a new urea derivative.

Country Status (1)

Country Link
CH (1) CH284214A (en)

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