CH284214A - Process for the production of a new urea derivative. - Google Patents
Process for the production of a new urea derivative.Info
- Publication number
- CH284214A CH284214A CH284214DA CH284214A CH 284214 A CH284214 A CH 284214A CH 284214D A CH284214D A CH 284214DA CH 284214 A CH284214 A CH 284214A
- Authority
- CH
- Switzerland
- Prior art keywords
- production
- urea derivative
- new urea
- new
- benzhydrol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
- C07C275/48—Y being a hydrogen or a carbon atom
- C07C275/50—Y being a hydrogen or an acyclic carbon atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Herstellung eines neuen Harnstoffderivates. C egenstand der vorliegenden Erfindung ist ein Verfahren zur Herstellung eines neuen Harnstoffderivates, welches dadurch gekenn zeichnet ist., dass man Benzhydrol mit Mono- acetvlharnstoff umsetzt.
Der bisher unbekannte 1-Benzhydryl-3- acetylharnstoff, welcher farblose Kristalle vom Sehmelzpunkt 153 bis 155 C bildet, be sitzt wertvolle pharmakologisehe Eigenschaf ten und soll als Arzneimittel verwendet wer den.
Beispiel: Einer Mischung von 7,4 g Benzhydrol, 4 g Acetylharnstoff, 50 em3 Essigsäure und 5 em3 Acetanhydrid wird eine Mischung von 5 em3 Essigsäure und 0,5 cm3 97o/oiger Schwefel säure zugesetzt. Die ;Mischung erwärmt sich spontan, und die Umsetzung wird durch Er- hitzen am RückflLisskühler. während 1.0 Mi nuten vervollständigt.
Das Reaktionsgemisch wird in 1000 ein- Wasser eingegossen, wor auf 1-Benzhydryl-3-acetylharnstoff auskri stallisiert. Die Verbindung wird abfiltriert, mit trockenem, eiskaltem Äthanol gewaschen und aus 35 em3 Äthanol umkristallisiert, wor auf sie einen Schmelzpunkt von 153 bis 1.55 C zeigt.
Process for the production of a new urea derivative. The subject of the present invention is a process for the preparation of a new urea derivative, which is characterized in that benzhydrol is reacted with monoacetylurea.
The previously unknown 1-benzhydryl-3-acetylurea, which forms colorless crystals from the melting point 153 to 155 C, has valuable pharmacological properties and is intended to be used as a drug.
Example: To a mixture of 7.4 g benzhydrol, 4 g acetylurea, 50 em3 acetic acid and 5 em3 acetic anhydride is added a mixture of 5 em3 acetic acid and 0.5 cm3 97% sulfuric acid. The mixture heats up spontaneously and the reaction is initiated by heating on the reflux condenser. Completed within 1.0 minutes.
The reaction mixture is poured into 1000 a water, where 1-benzhydryl-3-acetylurea auskri crystallized. The compound is filtered off, washed with dry, ice-cold ethanol and recrystallized from 35 em3 ethanol, whereupon it has a melting point of 153 to 1.55 ° C.
Claims (1)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US284214XA | 1949-07-12 | 1949-07-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH284214A true CH284214A (en) | 1952-07-15 |
Family
ID=21843358
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH284214D CH284214A (en) | 1949-07-12 | 1950-06-12 | Process for the production of a new urea derivative. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH284214A (en) |
-
1950
- 1950-06-12 CH CH284214D patent/CH284214A/en unknown
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