CH281036A - Process for the preparation of p-propylureido-benzalthiosemicarbazone. - Google Patents
Process for the preparation of p-propylureido-benzalthiosemicarbazone.Info
- Publication number
- CH281036A CH281036A CH281036DA CH281036A CH 281036 A CH281036 A CH 281036A CH 281036D A CH281036D A CH 281036DA CH 281036 A CH281036 A CH 281036A
- Authority
- CH
- Switzerland
- Prior art keywords
- benzalthiosemicarbazone
- preparation
- propylureido
- amino
- propyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Herstellung von p-Propylureido-benzalthiosemicarbazon. Gegenstand der vorliegenden Erfindung ist ein Verfahren zur Herstellung von p-Pro- pyltireido-benzalthiosemicarbazon der Formel
EMI0001.0004
welches dadurch gekennzeichnet ist, dass man den Propylester der Isoeyansäure auf p Ainino-benzalthiosemicarbazon einwirken lässt. Die Umsetzung wird vorzugsweise in einem Lösungsmittel, wie z. B. Pyridin, Aceton, Di- oxan, vorgenommen.
Beispiel: 1?,25 Gewichtsteile p-Amino-benzalthio- semicarbazon werden in 40 Gewichtsteilen Py- ridin gelöst und mit 5,67 Gewichtsteilen n-Pro- pylisocyanat vermischt. Das Gemisch wird über Nacht stehen gelassen und dann in ver dünnte Salzsäure gerührt. Das abgeschiedene kristallinische Reaktionsprodukt wird abge- saugt und mit Wasser gewaschen. Dann wird es in heissem Alkohol gelöst und durch lang same Verdünnung der Lösung mit Nasser kristallinisch ausgefällt und abgesaugt.
Es wird mit verdünntem Alkohol, Äther und Wasser nachgewaschen und getrocknet. Man erhält 11 Gewichtsteile p-Propylureido-benzal- thiosemicarbazon als gelbliches Kristallpulver vom F. 205 (Zers.).
Das Produkt soll als Heilmittel verwendet werden.
Process for the preparation of p-propylureido-benzalthiosemicarbazone. The present invention relates to a process for the preparation of p-propyltireido-benzalthiosemicarbazone of the formula
EMI0001.0004
which is characterized in that the propyl ester of isoeyanic acid is allowed to act on p amino-benzalthiosemicarbazone. The reaction is preferably carried out in a solvent such as. B. pyridine, acetone, dioxane made.
Example: 1.25 parts by weight of p-amino-benzalthiosemicarbazone are dissolved in 40 parts by weight of pyridine and mixed with 5.67 parts by weight of n-propyl isocyanate. The mixture is left to stand overnight and then stirred in dilute hydrochloric acid. The precipitated crystalline reaction product is filtered off with suction and washed with water. Then it is dissolved in hot alcohol and precipitated in crystalline form by slowly diluting the solution with water and suctioning off.
It is washed with diluted alcohol, ether and water and dried. 11 parts by weight of p-propylureido-benzal thiosemicarbazone are obtained as a yellowish crystal powder with a melting point of 205 (decomp.).
The product is intended to be used as a remedy.
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH278134T | 1949-12-21 | ||
CH281036T | 1949-12-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH281036A true CH281036A (en) | 1952-02-15 |
Family
ID=25731806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH281036D CH281036A (en) | 1949-12-21 | 1949-12-21 | Process for the preparation of p-propylureido-benzalthiosemicarbazone. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH281036A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8765802B2 (en) | 2007-06-12 | 2014-07-01 | Provid Pharmaceuticals, Inc. | Kinase inhibitors, compositions thereof, and methods of use therewith |
-
1949
- 1949-12-21 CH CH281036D patent/CH281036A/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8765802B2 (en) | 2007-06-12 | 2014-07-01 | Provid Pharmaceuticals, Inc. | Kinase inhibitors, compositions thereof, and methods of use therewith |
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