CH281038A - Process for the preparation of p-n-butylureido-benzalthiosemicarbazone. - Google Patents
Process for the preparation of p-n-butylureido-benzalthiosemicarbazone.Info
- Publication number
- CH281038A CH281038A CH281038DA CH281038A CH 281038 A CH281038 A CH 281038A CH 281038D A CH281038D A CH 281038DA CH 281038 A CH281038 A CH 281038A
- Authority
- CH
- Switzerland
- Prior art keywords
- butylureido
- benzalthiosemicarbazone
- preparation
- butyl
- weight
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
<B>Verfahren zur Herstellung von</B> p-n-Butylureido-benzalthiosemicarbazon. Gegenstand der vorliegenden Erfindung ist ein Verfahren zur Herstellung von p-il-Bu- tylureido-lieiizalthiosemicarbazon der Formel
EMI0001.0004
welches dadurch gekennzeichnet ist, dass man den ii-Butylester der Isocyansäure auf p Ainiiio-beiizalt.liioseinicarbazon einwirken lässt. Die Umsetzung wird vorzugsweise in einem LÖSluigSinittel, wie z.
B. Py ridin, Aeeton, Di- oxan, vorgenommen.
<I>Beispiel:</I> 9 Gewichtsteile p-Amino-beiizalthiosemi- carbazon werden in 40 Gewichtsteilen Pyridin gelöst und mit 9 Gewichtsteilen n-Butylisoeya- nat vermischt. Das Gemisch wird über Nacht stellen gelassen und darauf in verdünnte Salz säure gerührt. Das als dickes öl abgeschiedene Kondensationsprodukt wird abgetrennt, in verdünnter Natronlauge aufgenommen, die Lösung nach Zusatz von Tierkohle filtriert und das Filtrat mit Essigsäure angesäuert, wobei sieh das Kondensationsprodukt als lang sam erstarrendes öl ausscheidet.
Nach einigem Stehen wird das feste Produkt abgesaugt, ge trocknet und aus einem Gemisch von Essig ester und Benzol umkristallisiert. Man erhält das p-n-Butylureido-benzalthiosemicarbazon als gelbliches Pulver vom Zersetzungspunkt 195 .
Es soll als Heilmittel verwendet werden.
<B> Process for the production of </B> p-n-butylureido-benzalthiosemicarbazone. The present invention relates to a process for the preparation of p-il-butylureido-lieiizalthiosemicarbazone of the formula
EMI0001.0004
which is characterized in that the ii-butyl ester of isocyanic acid is allowed to act on p Ainiiio-beiizalt.liioseinicarbazon. The reaction is preferably carried out in a LÖSluigSinittel, such as.
B. Pyridine, Aeeton, Di- oxane, made.
<I> Example: </I> 9 parts by weight of p-amino-beiizalthiosemicarbazone are dissolved in 40 parts by weight of pyridine and mixed with 9 parts by weight of n-butyl isoeyanate. The mixture is left to stand overnight and then stirred in dilute hydrochloric acid. The condensation product deposited as a thick oil is separated off, taken up in dilute sodium hydroxide solution, the solution is filtered after adding animal charcoal and the filtrate is acidified with acetic acid, the condensation product separating out as a slowly solidifying oil.
After standing for a while, the solid product is filtered off with suction, dried and recrystallized from a mixture of ethyl acetate and benzene. The p-n-butylureido-benzalthiosemicarbazone is obtained as a yellowish powder with a decomposition point of 195.
It is said to be used as a remedy.
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH281038T | 1949-12-21 | ||
CH278134T | 1949-12-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH281038A true CH281038A (en) | 1952-02-15 |
Family
ID=25731808
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH281038D CH281038A (en) | 1949-12-21 | 1949-12-21 | Process for the preparation of p-n-butylureido-benzalthiosemicarbazone. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH281038A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8765802B2 (en) | 2007-06-12 | 2014-07-01 | Provid Pharmaceuticals, Inc. | Kinase inhibitors, compositions thereof, and methods of use therewith |
-
1949
- 1949-12-21 CH CH281038D patent/CH281038A/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8765802B2 (en) | 2007-06-12 | 2014-07-01 | Provid Pharmaceuticals, Inc. | Kinase inhibitors, compositions thereof, and methods of use therewith |
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