CH281038A - Process for the preparation of p-n-butylureido-benzalthiosemicarbazone. - Google Patents

Process for the preparation of p-n-butylureido-benzalthiosemicarbazone.

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Publication number
CH281038A
CH281038A CH281038DA CH281038A CH 281038 A CH281038 A CH 281038A CH 281038D A CH281038D A CH 281038DA CH 281038 A CH281038 A CH 281038A
Authority
CH
Switzerland
Prior art keywords
butylureido
benzalthiosemicarbazone
preparation
butyl
weight
Prior art date
Application number
Other languages
German (de)
Inventor
Ag Dr A Wander
Original Assignee
Ag Dr A Wander
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag Dr A Wander filed Critical Ag Dr A Wander
Publication of CH281038A publication Critical patent/CH281038A/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  <B>Verfahren zur Herstellung von</B>     p-n-Butylureido-benzalthiosemicarbazon.       Gegenstand der vorliegenden Erfindung ist ein Verfahren zur Herstellung von     p-il-Bu-          tylureido-lieiizalthiosemicarbazon    der Formel  
EMI0001.0004     
    welches dadurch gekennzeichnet ist, dass man       den        ii-Butylester    der     Isocyansäure    auf p  Ainiiio-beiizalt.liioseinicarbazon einwirken lässt.  Die Umsetzung wird vorzugsweise in einem       LÖSluigSinittel,    wie z.

   B.     Py        ridin,        Aeeton,        Di-          oxan,        vorgenommen.     



  <I>Beispiel:</I>  9     Gewichtsteile        p-Amino-beiizalthiosemi-          carbazon    werden in 40 Gewichtsteilen     Pyridin     gelöst und mit 9 Gewichtsteilen     n-Butylisoeya-          nat        vermischt.    Das     Gemisch    wird über Nacht  stellen gelassen und darauf in verdünnte Salz  säure gerührt. Das als dickes öl abgeschiedene  Kondensationsprodukt wird abgetrennt, in       verdünnter    Natronlauge aufgenommen, die    Lösung nach Zusatz von Tierkohle filtriert  und das Filtrat mit Essigsäure angesäuert,  wobei sieh das Kondensationsprodukt als lang  sam erstarrendes öl ausscheidet.

   Nach einigem  Stehen wird das feste Produkt abgesaugt, ge  trocknet und aus einem Gemisch von Essig  ester und Benzol umkristallisiert. Man erhält  das     p-n-Butylureido-benzalthiosemicarbazon     als gelbliches Pulver vom Zersetzungspunkt  195 .  



  Es soll als Heilmittel verwendet werden.



  <B> Process for the production of </B> p-n-butylureido-benzalthiosemicarbazone. The present invention relates to a process for the preparation of p-il-butylureido-lieiizalthiosemicarbazone of the formula
EMI0001.0004
    which is characterized in that the ii-butyl ester of isocyanic acid is allowed to act on p Ainiiio-beiizalt.liioseinicarbazon. The reaction is preferably carried out in a LÖSluigSinittel, such as.

   B. Pyridine, Aeeton, Di- oxane, made.



  <I> Example: </I> 9 parts by weight of p-amino-beiizalthiosemicarbazone are dissolved in 40 parts by weight of pyridine and mixed with 9 parts by weight of n-butyl isoeyanate. The mixture is left to stand overnight and then stirred in dilute hydrochloric acid. The condensation product deposited as a thick oil is separated off, taken up in dilute sodium hydroxide solution, the solution is filtered after adding animal charcoal and the filtrate is acidified with acetic acid, the condensation product separating out as a slowly solidifying oil.

   After standing for a while, the solid product is filtered off with suction, dried and recrystallized from a mixture of ethyl acetate and benzene. The p-n-butylureido-benzalthiosemicarbazone is obtained as a yellowish powder with a decomposition point of 195.



  It is said to be used as a remedy.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von p-n-Butyl- ureido-ben7althiosemicarbazon der Formel EMI0001.0027 dadurch gekennzeichnet, dass man n-Butyliso- cyanat auf p-Aniino-beiizalthiosemicarbazon einwirken lässt. Das gebildete Produkt ist ein gelbliches Pulver vom Zersetzungspunkt 195 . PATENT CLAIM: Process for the production of p-n-butyl ureido-ben7althiosemicarbazone of the formula EMI0001.0027 characterized in that n-butyl isocyanate is allowed to act on p-aniino-bizalthiosemicarbazone. The product formed is a yellowish powder with a decomposition point of 195.
CH281038D 1949-12-21 1949-12-21 Process for the preparation of p-n-butylureido-benzalthiosemicarbazone. CH281038A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH281038T 1949-12-21
CH278134T 1949-12-21

Publications (1)

Publication Number Publication Date
CH281038A true CH281038A (en) 1952-02-15

Family

ID=25731808

Family Applications (1)

Application Number Title Priority Date Filing Date
CH281038D CH281038A (en) 1949-12-21 1949-12-21 Process for the preparation of p-n-butylureido-benzalthiosemicarbazone.

Country Status (1)

Country Link
CH (1) CH281038A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8765802B2 (en) 2007-06-12 2014-07-01 Provid Pharmaceuticals, Inc. Kinase inhibitors, compositions thereof, and methods of use therewith

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8765802B2 (en) 2007-06-12 2014-07-01 Provid Pharmaceuticals, Inc. Kinase inhibitors, compositions thereof, and methods of use therewith

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