CH281037A - Process for the preparation of p-isopropylureido-benzalthiosemicarbazone. - Google Patents

Process for the preparation of p-isopropylureido-benzalthiosemicarbazone.

Info

Publication number
CH281037A
CH281037A CH281037DA CH281037A CH 281037 A CH281037 A CH 281037A CH 281037D A CH281037D A CH 281037DA CH 281037 A CH281037 A CH 281037A
Authority
CH
Switzerland
Prior art keywords
benzalthiosemicarbazone
isopropylureido
preparation
weight
parts
Prior art date
Application number
Other languages
German (de)
Inventor
Ag Dr A Wander
Original Assignee
Ag Dr A Wander
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag Dr A Wander filed Critical Ag Dr A Wander
Publication of CH281037A publication Critical patent/CH281037A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Herstellung von     p-Isopropylureido-benzalthiosemicarbazon.            Clegenstand    der vorliegenden Erfindung  ist ein Verfahren zur Herstellung von p-Iso-         propylureido-benzalthiosemicarbazon    der For  mel  
EMI0001.0004     
    welches dadurch gekennzeichnet ist, dass man  (Ion     1sopropylester    der     Isoeyansäure    auf p  Ainino-berizalt.hiosenricarbazon einwirken lässt.  Die Umsetzung wird vorzugsweise in einem  Lösungsmittel, wie z. B.     Pyridin,    Aceton,     Di-          oxan,    vorgenommen.  



  <I>.</I>     Beispiel:     9 Gewichtsteile     p-Anrino-benzalthiosemi-          earbazon    werden in 40 Gewichtsteilen     Pvridin          rrelöst    und     finit    6 Gewichtsteilen     Isopropyliso-          cyanat    vermischt. Das     Cxemisch    wird nun über  Nacht stehen gelassen und darauf in ver  dünnte Salzsäure gerührt, wobei sich das  Kondensationsprodukt. als dickes Öl abschei  det.

   Dieses wird abgetrennt, in verdünnter    Natronlauge aufgenommen, die Lösung nach  Zusatz von Tierkohle filtriert und das Filtrat  mit Essigsäure angesäuert, wobei sich das  Kondensationsprodukt als langsam erstarren  des Öl ausscheidet. Nach einigem Stehen wird  das feste Produkt abgesaugt, getrocknet und  aus einem Gemisch von Essigester und Benzol  umkristallisiert. Man erhält das     p-Isopropyl-          ureido-benzalthiosemicarbazon    als gelbliches  Pulver vom Zersetzungspunkt 198 .  



  Es soll als     Heilmittel    verwendet werden.



  Process for the preparation of p-isopropylureido-benzalthiosemicarbazone. The present invention is a process for the preparation of p-isopropylureido-benzalthiosemicarbazone of the formula
EMI0001.0004
    which is characterized in that (ion isopropyl ester of isoeyanoic acid is allowed to act on p amino-berizalt.hiosenricarbazone. The reaction is preferably carried out in a solvent such as pyridine, acetone, dioxane.



  <I>. </I> Example: 9 parts by weight of p-anrino-benzalthiosemi-earbazon are dissolved in 40 parts by weight of pvridine and finely 6 parts by weight of isopropyl isocyanate are mixed. The mixture is then left to stand overnight and then stirred in dilute hydrochloric acid, the condensation product being formed. separates out as thick oil.

   This is separated off, taken up in dilute sodium hydroxide solution, the solution is filtered after adding animal charcoal and the filtrate is acidified with acetic acid, the condensation product separating out as the oil slowly solidify. After standing for a while, the solid product is filtered off with suction, dried and recrystallized from a mixture of ethyl acetate and benzene. The p-isopropylureido-benzalthiosemicarbazone is obtained as a yellowish powder with a decomposition point of 198.



  It is said to be used as a remedy.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von p-Isopro- pylureido-benzalthiosemicarbazon der Formel EMI0001.0025 dadurch gekennzeichnet, dass man den Isopro- pylester der Isocyansäure auf p-Amino-benzal- thiosemiearbazon einwirken lässt. Das erhaltene Produkt. ist ein gelbliches Pulver vom Zersetzungspunkt l98 . PATENT CLAIM: Process for the production of p-isopropylureido-benzalthiosemicarbazone of the formula EMI0001.0025 characterized in that the isopropyl ester of isocyanic acid is allowed to act on p-amino-benzal thiosemiearbazon. The product obtained. is a yellowish powder with a decomposition point of 198.
CH281037D 1949-12-21 1949-12-21 Process for the preparation of p-isopropylureido-benzalthiosemicarbazone. CH281037A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH281037T 1949-12-21
CH278134T 1949-12-21

Publications (1)

Publication Number Publication Date
CH281037A true CH281037A (en) 1952-02-15

Family

ID=25731807

Family Applications (1)

Application Number Title Priority Date Filing Date
CH281037D CH281037A (en) 1949-12-21 1949-12-21 Process for the preparation of p-isopropylureido-benzalthiosemicarbazone.

Country Status (1)

Country Link
CH (1) CH281037A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8765802B2 (en) 2007-06-12 2014-07-01 Provid Pharmaceuticals, Inc. Kinase inhibitors, compositions thereof, and methods of use therewith

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8765802B2 (en) 2007-06-12 2014-07-01 Provid Pharmaceuticals, Inc. Kinase inhibitors, compositions thereof, and methods of use therewith

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