CH236351A - Process for the preparation of a halogen lactam. - Google Patents

Process for the preparation of a halogen lactam.

Info

Publication number
CH236351A
CH236351A CH236351DA CH236351A CH 236351 A CH236351 A CH 236351A CH 236351D A CH236351D A CH 236351DA CH 236351 A CH236351 A CH 236351A
Authority
CH
Switzerland
Prior art keywords
halogen
preparation
lactam
chloro
methyl
Prior art date
Application number
Other languages
German (de)
Inventor
Keil Friedrich Ing Dr
Original Assignee
Temmler Theodor H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Temmler Theodor H filed Critical Temmler Theodor H
Publication of CH236351A publication Critical patent/CH236351A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C07D223/10—Oxygen atoms attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Description

  

  Verfahren zur Herstellung eines     Hal0genlaetams.       Gegenstand des vorliegenden Patentes ist       ein    Verfahren zur Herstellung von     a-Chlor-          y-methyl-a-caprolactam,    das dadurch gekenn  zeichnet ist, dass man     o-Chlor-p-methyl-cyclo-          heganon    in Gegenwart von Katalysatoren mit       Stickstoffwasserstoffsäure    behandelt.    Die neue Verbindung soll als     Arzneimittel     Verwendung finden.

      <I>Beispiel:</I>    In ein Gemisch von 80 Teilen konzentrier  ter Schwefelsäure und 400 Teilen Benzol wer  den vorsichtig 60 Teile     o-Chlor-p-methyl-          cycloheganon,    gelöst in 600 Teilen Benzol,  gemeinsam mit 380 Teilen     einer    etwa 6 %     igen          benzolischen        Stickstoffwasserstoffsäure    ein  getragen.

   Nach Beendigung der Reaktion    wird aus der     Schwefelsäureschicht    durch Ver  setzen mit Eis nach dem Neutralisieren mit  Chloroform das gebildete     a-Chlor-y-methyl-          s-caprolactam    erhalten, das bei 15     mm.    bei  195  destilliert und     kristallin    erstarrt. Nach       Umkristallisieren    aus     Benzin    schmilzt es  bei     1;26 .  



  Process for the production of a halogen latam. The subject of the present patent is a process for the preparation of a-chloro-y-methyl-a-caprolactam, which is characterized in that o-chloro-p-methyl-cyclo-heganone is treated with hydrazoic acid in the presence of catalysts. The new compound is said to be used as a drug.

      <I> Example: </I> In a mixture of 80 parts of concentrated sulfuric acid and 400 parts of benzene, carefully put 60 parts of o-chloro-p-methylcycloheganone, dissolved in 600 parts of benzene, together with 380 parts of about 6 % strength benzene hydrazoic acid.

   After the reaction has ended, the a-chloro-y-methyl-s-caprolactam is obtained from the sulfuric acid layer by adding ice after neutralization with chloroform, which is 15 mm. distilled at 195 and solidified in crystalline form. After recrystallizing from gasoline, it melts at 1; 26.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von a-Chlor- y-methyl-s-caprolactam, dadurch gekennzeich net, dass man o-Chlor-p-methyl-cycloheganon in Gegenwart von Katalysatoren mit Stick stoffwasserstoffsäure behandelt. Die neue Verbindung schmilzt aus Benzin umkristallisiert bei 126 . PATENT CLAIM: Process for the production of a-chloro-y-methyl-s-caprolactam, characterized in that o-chloro-p-methyl-cycloheganone is treated with nitrogen hydrochloric acid in the presence of catalysts. The new compound melts from gasoline recrystallized at 126.
CH236351D 1941-01-14 1941-12-29 Process for the preparation of a halogen lactam. CH236351A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE236351X 1941-01-14
CH232461T 1941-12-29

Publications (1)

Publication Number Publication Date
CH236351A true CH236351A (en) 1945-01-31

Family

ID=25727722

Family Applications (1)

Application Number Title Priority Date Filing Date
CH236351D CH236351A (en) 1941-01-14 1941-12-29 Process for the preparation of a halogen lactam.

Country Status (1)

Country Link
CH (1) CH236351A (en)

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