CH193770A - Process for preventing the decomposition of aqueous solutions of ascorbic acid salts of histidine. - Google Patents
Process for preventing the decomposition of aqueous solutions of ascorbic acid salts of histidine.Info
- Publication number
- CH193770A CH193770A CH193770DA CH193770A CH 193770 A CH193770 A CH 193770A CH 193770D A CH193770D A CH 193770DA CH 193770 A CH193770 A CH 193770A
- Authority
- CH
- Switzerland
- Prior art keywords
- histidine
- ascorbic acid
- aqueous solutions
- acid salts
- decomposition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/62—Three oxygen atoms, e.g. ascorbic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Verhinderung der Zersetzung wässeriger Lösungen von ascorbinsauren Salzen des Histidins. Wenn man Ascorbinsäure mit Elistidin- base neutralisiert, so sind die Lösungen der entstehenden Salze nicht haltbar, was schon daran zu erkennen ist, dass sie sich sehr bald himbeerrot bis dunkel-orangebraun fär ben. Löst man z. B. 3,1 g Histidinbase (2100 Mol.) und<B>1,76</B> g Ascorbinsäure (1100 Mol.) in 100 cc Wasser, so hat die entstehende Salzlösung ein p$ von 6,0.
Sie verfärbt sich in kürzester Zeit, zunächst hell rosa, dann himbeerrot, schliesslich dunkel orangebraun. Lösungen von andern ascorbin- sauren Salzen, z. B. Natriumascorbat, oder andern Histidinsalzen, z. B. Histidinhydro- chlorid, vom gleichen p$ zeigen diese rasche Verfärbung nicht, es ist dies eine besondere Eigenschaft der Lösungen von ascorbinsauren Salzen des Histidins. Die Konstitution der entstehenden gefärbten Verbindungen wurde noch nicht ermittelt.
Die Verfärbung lässt sich nun vollständig verhindern, wenn man die wässerigen Lösungen der ascorbinsauren Salze des Histidins mit sauerstofffreien Gasen sättigt und in mit diesen Gasen gefüllten Behältern aufbewahrt.
<I>Beispiel 1:</I> 310 Teile Histidinbase und 176 Teile As corbinsäure werden unter konstantem Durch leiten von Stickstoff in 5000 Teilen Wasser gelöst, welches vorher ausgekocht und unter Stickstoffdurchleitung abgekühlt worden war. Die Einleitung des Stickstoffes wird bis zur Sättigung der Lösung fortgesetzt. Die fertige Lösung wird in mit Stickstoff gefüllte Am pullen abgefüllt, welche sogleich zugeschmol- zen werden. Diese Lösungen bleiben dauernd farblos, ja sie können sogar im strömenden Dampfe erhitzt (sterilisiert) werden, ohne dass eine merkliche Verfärbung auftritt.
<I>Beispiel 2:</I> <B>209,5</B> Teile Histidinmonohydrochlorid (-f- 1 Kristallwasser) und 199 Teile Natriumascorbat werden in 5000 Teilen sauerstofffreiem Was ser gelöst und während der Lösung Kohlen- säure eingeleitet. Aus den Gefässen, in wel chen die Lösung aufbewahrt werden soll, wird die Luft durch Einleitung von Kohlensäure entfernt. Die Lösungen bleiben farblos.
Process for preventing the decomposition of aqueous solutions of ascorbic acid salts of histidine. If ascorbic acid is neutralized with elistidine base, the solutions of the resulting salts cannot be kept, which can be seen from the fact that they very soon turn raspberry-red to dark-orange-brown. If you solve z. B. 3.1 g of histidine base (2100 mol.) And 1.76 g of ascorbic acid (1100 mol.) In 100 cc of water, the resulting salt solution has a p $ of 6.0.
It changes color in a very short time, initially light pink, then raspberry red, and finally dark orange-brown. Solutions of other ascorbic acid salts, e.g. B. sodium ascorbate, or other histidine salts, e.g. B. histidine hydrochloride, of the same p $ do not show this rapid discoloration; this is a special property of solutions of ascorbic acid salts of histidine. The constitution of the resulting colored compounds has not yet been determined.
The discoloration can now be completely prevented if the aqueous solutions of the ascorbic acid salts of histidine are saturated with oxygen-free gases and stored in containers filled with these gases.
Example 1: 310 parts of histidine base and 176 parts of ascorbic acid are dissolved in 5000 parts of water, which had previously been boiled and cooled while nitrogen was passed through, while nitrogen was constantly being passed through. The introduction of nitrogen is continued until the solution is saturated. The finished solution is filled into ampoules filled with nitrogen, which are immediately melted shut. These solutions remain permanently colorless, they can even be heated (sterilized) in flowing steam without noticeable discoloration.
<I> Example 2: </I> <B> 209.5 </B> parts of histidine monohydrochloride (-f- 1 crystal water) and 199 parts of sodium ascorbate are dissolved in 5000 parts of oxygen-free water and carbonic acid is introduced during the dissolution. The air is removed from the vessels in which the solution is to be stored by introducing carbon dioxide. The solutions remain colorless.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH193770T | 1936-07-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH193770A true CH193770A (en) | 1937-10-31 |
Family
ID=4439051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH193770D CH193770A (en) | 1936-07-09 | 1936-07-09 | Process for preventing the decomposition of aqueous solutions of ascorbic acid salts of histidine. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH193770A (en) |
-
1936
- 1936-07-09 CH CH193770D patent/CH193770A/en unknown
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