CH183326A - Process for the preparation of 1-cyclohexyl-2,3-dimethyl-4-methylamino-5-pyrazolone. - Google Patents

Process for the preparation of 1-cyclohexyl-2,3-dimethyl-4-methylamino-5-pyrazolone.

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Publication number
CH183326A
CH183326A CH183326DA CH183326A CH 183326 A CH183326 A CH 183326A CH 183326D A CH183326D A CH 183326DA CH 183326 A CH183326 A CH 183326A
Authority
CH
Switzerland
Prior art keywords
dimethyl
pyrazolone
cyclohexyl
methylamino
preparation
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH183326A publication Critical patent/CH183326A/en

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Description

  

  Verfahren zur Herstellung von     1-Cyclohegyl-2,3-dimethyl-4-methylamino-ö-pyrazolon.       Gegenstand der     Erfindung    ist ein Ver  fahren zur Herstellung von     1-Cyclohexyl-2,3-          dimethyl-4-methylamino-5-pyrazolon,    das  dadurch gekennzeichnet ist, dass man     1-Cy-          clohegyl-    2, 3 -     dimethyl-    4-     amino    -     5-pyrazolon     durch Erhitzen mit     Benzaldehyd    in die     4-          Benzylidenverbindung    überführt,

   diese mit  einem     Methylierungsmittel    umsetzt und den       Benzaldehyd    durch     Destillation    mit Wasser  dampf abspaltet.  



  Die neue     Verbindung    schmilzt bei 102    und ist in Wasser und Alkohol löslich. Sie  soll als     Arzneimittel    verwandt werden.  



  <I>Beispiel:</I>  Man überführt das gemäss Patent Nr.       173909    erhaltene     1-Cyclohegyl-2,3-dimethyl-          4-amino-5-pyrazolon    durch     Erhitzen    mit       Benzaldehyd    in seine     4-Benzylidenverbin-          dung    und lagert an dieses Produkt     Dimethyl-          sulfat    an.

   Das nach Abspaltung des     Benzal-          dehyds    im Wege der Destillation mit  Wasserdampf erhaltene 1-Cyclohexyl-2,3-di-         methyl-4-methylamino-5-pyrazolon    schmilzt  nach     Umlösen    aus einem     Gemisch    von     Hexa-          hydrobenzol        und    Benzin bei 102' und zeigt  ähnliche Löslichkeitsverhältnisse wie die     Di-          methylverbindung.  



  Process for the preparation of 1-cyclohegyl-2,3-dimethyl-4-methylamino-δ-pyrazolone. The invention relates to a process for the preparation of 1-cyclohexyl-2,3-dimethyl-4-methylamino-5-pyrazolone, which is characterized in that 1-cyclohegyl-2, 3-dimethyl-4-amino - 5-pyrazolone is converted into the 4-benzylidene compound by heating with benzaldehyde,

   this reacts with a methylating agent and splits off the benzaldehyde by distillation with steam.



  The new compound melts at 102 and is soluble in water and alcohol. It is intended to be used as a medicine.



  <I> Example: </I> The 1-cyclohegyl-2,3-dimethyl-4-amino-5-pyrazolone obtained according to patent no. 173909 is converted into its 4-benzylidene compound by heating with benzaldehyde and stored on this Product dimethyl sulfate.

   The 1-cyclohexyl-2,3-dimethyl-4-methylamino-5-pyrazolone obtained after the benzaldehyde has been split off by distillation with steam melts after dissolving from a mixture of hexahydrobenzene and gasoline at 102 ° and shows similar solubility ratios as the dimethyl compound.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von 1-Cyclo- hexyl - 2,3-dimethyl-4-methylamino-5-pyrazo- lon, dadurch gekennzeichnet, dass man 1-Cy- clohexyl -<B>2,3</B> - dimethyl -4-amino - 5 -pyrazolon durch Erhitzen mit Benzaldehyd in die 4- Benzylidenverbindung überführt, PATENT CLAIM: Process for the production of 1-cyclohexyl - 2,3-dimethyl-4-methylamino-5-pyrazolone, characterized in that 1-cyclohexyl - <B> 2,3 </B> - dimethyl -4-amino - 5 -pyrazolone converted into the 4-benzylidene compound by heating with benzaldehyde, diese mit einem Methylierungsmittel umsetzt und den Benzaldehyd durch Destillation mit Wasser dampf abspaltet. Die neue Verbindung schmilzt bei 102' und ist in Wasser und Alkohol löslich. Sie soll als Arzneimittel verwandt werden. this reacts with a methylating agent and splits off the benzaldehyde by distillation with steam. The new compound melts at 102 'and is soluble in water and alcohol. It is intended to be used as a medicine.
CH183326D 1933-02-08 1934-02-05 Process for the preparation of 1-cyclohexyl-2,3-dimethyl-4-methylamino-5-pyrazolone. CH183326A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE183326X 1933-02-08

Publications (1)

Publication Number Publication Date
CH183326A true CH183326A (en) 1936-03-31

Family

ID=5718504

Family Applications (1)

Application Number Title Priority Date Filing Date
CH183326D CH183326A (en) 1933-02-08 1934-02-05 Process for the preparation of 1-cyclohexyl-2,3-dimethyl-4-methylamino-5-pyrazolone.

Country Status (1)

Country Link
CH (1) CH183326A (en)

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