CH176154A - Process for the preparation of a derivative of 2-ethoxy-5-acetaminopyridine. - Google Patents

Process for the preparation of a derivative of 2-ethoxy-5-acetaminopyridine.

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Publication number
CH176154A
CH176154A CH176154DA CH176154A CH 176154 A CH176154 A CH 176154A CH 176154D A CH176154D A CH 176154DA CH 176154 A CH176154 A CH 176154A
Authority
CH
Switzerland
Prior art keywords
acetaminopyridine
ethoxy
preparation
derivative
act
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellschaft Chem Heyden
Original Assignee
Heyden Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heyden Chem Fab filed Critical Heyden Chem Fab
Publication of CH176154A publication Critical patent/CH176154A/en

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Description

  

  Verfahren zur Herstellung eines     Abkömmlings    des     2-Äthogy-6-acetaminopyridiii.       Es wurde gefunden, dass     Oxy-    und     Amino-          pyridinverbindungen    die Neigung besitzen,  sich mit     substituierten        Barbitursäuren    zu  Molekülverbindungen zu vereinigen. Die so  erhaltenen Abkömmlinge stellen bestimmte,  kristallisierte Verbindungen dar, die sich in  ihren physikalischen Eigenschaften von den  jeweiligen Ausgangsstoffen wesentlich unter  scheiden.  



  Man erhält derartige Abkömmlinge von       Oxy-    und     Aminopyridinverbindungen,    indem  man beispielsweise letztere in einer zwei  Molekülen entsprechenden     Menge    einer sub  stituierten     Barbitursäure    verschmilzt. Man  kann aber auch die Komponenten in Löse  mitteln aufeinander einwirken lassen und die  Molekülverbindungen durch Auskristallisieren  oder Eindampfen gewinnen oder Salze von       Barbitursäuren    mit Salzen der genannten       Pyridinverbindungen    zur Umsetzung bringen.  



  Gegenstand des vorliegenden Patentes ist  nun ein Verfahren zur Herstellung eines Ab-         kömmlings    des 2     Ä.thoxy-5-acetaminopyridins,     welches dadurch gekennzeichnet ist, dass man  auf     Diäthylbarbitursäure        2-Äthoxy-5-aceta-          minopyridin    einwirken lässt. Man erhält dabei  eine Verbindung von Schmelzpunkt -112 bis  <B>115</B>  , welche sich aus Benzol     umkristallisie-          ren    lässt.

      <I>Beispiel</I>    Man verschmilzt ein Teil     Diäthylbarbitur-          säure    und 2 Teile     2-Äthoxy-5-acetaminopyri-          din    bei 140  . Nach dem Erstarren der klaren  Schmelze wird aus Wasser oder aus Benzol  umkristallisiert. Die so erhaltene Verbindung  schmilzt bei 112 bis 115   und enthält auf  <B>1</B>     Mol        C8E1203N2   <B>2</B>     Mol        C9H1202N2.  



  Process for the preparation of a derivative of 2-Ethogy-6-acetaminopyridiii. It has been found that oxy- and aminopyridine compounds have a tendency to combine with substituted barbituric acids to form molecular compounds. The derivatives obtained in this way represent specific, crystallized compounds which differ significantly in their physical properties from the respective starting materials.



  Such derivatives of oxy- and aminopyridine compounds are obtained, for example, by fusing the latter in an amount of a substituted barbituric acid corresponding to two molecules. However, the components can also act on one another in solvents and the molecular compounds can be obtained by crystallization or evaporation, or salts of barbituric acids can be reacted with salts of the pyridine compounds mentioned.



  The present patent now relates to a process for the production of a derivative of 2 Ä.thoxy-5-acetaminopyridine, which is characterized in that 2-ethoxy-5-acetaminopyridine is allowed to act on diethylbarbituric acid. This gives a compound with a melting point of -112 to 115, which can be recrystallized from benzene.

      <I> Example </I> One part of diethylbarbituric acid and 2 parts of 2-ethoxy-5-acetaminopyridine are fused at 140. After the clear melt has solidified, it is recrystallized from water or from benzene. The compound obtained in this way melts at 112 to 115 and contains <B> 1 </B> mole of C8E1203N2 <B> 2 </B> mole of C9H1202N2.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines Abkömm lings des 2-Äthoxy-5-acetaminopyridins, da durch gekennzeichnet, dass man 2-Äthoxy-5- acetaminopyridin auf Diäthylbarbitursäure einwirken lässt. Die erhaltene Verbindung schmilzt bei 112 bis<B>115'</B> und enthält auf 1 DZol Csg120BN2 <B>2</B> Mol C9g12O2N2. Sie soll therapeutische Verwendung finden. UNTERANSPRüCHE 1. PATENT CLAIM: Process for the preparation of a descendant of 2-ethoxy-5-acetaminopyridine, characterized in that 2-ethoxy-5-acetaminopyridine is allowed to act on diethylbarbituric acid. The compound obtained melts at 112 to 115 'and contains 2 mol C9g12O2N2 for every 1 double of Csg120BN2. It should find therapeutic use. SUBCLAIMS 1. Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man die Komponen- ten bei erhöhter Temperatur verschmilzt. 2. Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man die Komponen ten in Lösung oder Suspension aufeinan der einwirken lässt. Method according to patent claim, characterized in that the components are fused at an elevated temperature. 2. The method according to claim, characterized in that the components are allowed to act on one another in solution or suspension.
CH176154D 1933-03-31 1934-01-29 Process for the preparation of a derivative of 2-ethoxy-5-acetaminopyridine. CH176154A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE176154X 1933-03-31

Publications (1)

Publication Number Publication Date
CH176154A true CH176154A (en) 1935-03-31

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ID=5696597

Family Applications (1)

Application Number Title Priority Date Filing Date
CH176154D CH176154A (en) 1933-03-31 1934-01-29 Process for the preparation of a derivative of 2-ethoxy-5-acetaminopyridine.

Country Status (1)

Country Link
CH (1) CH176154A (en)

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