CH175921A - Process for the preparation of stable solutions of a salt of 4-B-methoxyethylaminobenzoic acid-B-diethylaminoethyl ester. - Google Patents

Process for the preparation of stable solutions of a salt of 4-B-methoxyethylaminobenzoic acid-B-diethylaminoethyl ester.

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Publication number
CH175921A
CH175921A CH175921DA CH175921A CH 175921 A CH175921 A CH 175921A CH 175921D A CH175921D A CH 175921DA CH 175921 A CH175921 A CH 175921A
Authority
CH
Switzerland
Prior art keywords
acid
salt
methoxyethylaminobenzoic
diethylaminoethyl ester
preparation
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH175921A publication Critical patent/CH175921A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

  

  Verfahren zur Darstellung haltbarer Lösungen eines Salzes des       4-,Q        -Methoxyäthylaminobenzoesäur        e-ss-diäthylaminoäthylesters.       Gegenstand vorliegender Erfindung ist  ein Verfahren zur Herstellung haltbarer Lö  sungen eines Salzes des     4-ss-Methoxyäthyl-          aminobenzoesäur-e-p-diäthylaminoäthylesters,     welches dadurch gekennzeichnet ist, dass man  den     4-p-Methoxyäthylamirroberrzoesäure-ss-diä-          thylaminoäthylester    mit Zitronensäure zur  Umsetzung bringt und das so erhaltene Salz  unter Zusatz von     Prolamin    und Weizen  schleim in Lösung bringt.  



  Die so erhaltene klare Lösung ist thera  peutisch wertvoll und insbesondere für die       Lumbalanaesthesie    geeignet.    <I>Beispiel:</I>    2,9     gr.        4-p-Methoxyäthylaminobenzoesäure-          P-diäthylaminoätbylester    (Base) werden mit  2,1     gr.    Zitronensäure in 45 cm' Wasser 30  Minuten auf dem Dampfbad erwärmt.

   Hier  auf werden 20 cm' Alkohol, 4     cms    einer  alkoholischen Lösung von     Prolamin    sowie       20        cm'        Weizenschleim        mit        0,75        %    Trocken-         rückstand        nacheinanderzugesetzt.    Das Ganze  wird mit destilliertem Wasser auf 300 cm'  aufgefüllt. Die Lösung wird     filtriert    und in  Ampullen abgefüllt. Die Ampullen werden  bei 105 0 10 Minuten sterilisiert.



  Process for the preparation of stable solutions of a salt of 4-, Q -methoxyethylaminobenzoic acid e-ss-diethylaminoethyl ester. The present invention relates to a process for the production of stable solutions of a salt of 4-ß-methoxyethyl aminobenzoic acid ep-diethylaminoethyl ester, which is characterized in that the 4-p-methoxyethylamirroberrzoic acid ß-diethylaminoethyl ester is reacted with citric acid and the salt thus obtained, with the addition of prolamine and wheat mucilage, is dissolved.



  The clear solution obtained in this way is therapeutically valuable and particularly suitable for lumbar anesthesia. <I> Example: </I> 2.9 g of 4-p-methoxyethylaminobenzoic acid-P-diethylaminoethyl ester (base) are heated with 2.1 g of citric acid in 45 cm of water for 30 minutes on the steam bath.

   Here 20 cm 'of alcohol, 4 cms of an alcoholic solution of prolamin and 20 cm' of wheat gruel with 0.75% dry residue are added one after the other. The whole is made up to 300 cm 'with distilled water. The solution is filtered and filled into ampoules. The ampoules are sterilized at 105 ° for 10 minutes.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung haltbarer Lö sungen eines Salzes des 4-ss-Methoxyäthyl- aminobenzoesäure-p-diäthylaminoäthylesters, dadurch gekennzeichnet, dass man den 4-p Methoxyäthylaminobenzoesäure-ss-diäthylami noäthylester mit Zitronensäure zur Umsetzung bringt und das so erhaltene Salz unter Zu satz von Prolamin und Weizenschleim in Lösung bringt. Die so erhaltene klare Lösung ist thera peutisch wertvoll und insbesondere für die Lumbalanaesthesie geeignet. PATENT CLAIM: Process for the production of durable solutions of a salt of 4-ss-methoxyethyl aminobenzoic acid p-diethylaminoethyl ester, characterized in that the 4-p methoxyethylaminobenzoic acid ss-diethylaminoethyl ester is reacted with citric acid and the salt thus obtained is added to Brings set of prolamin and wheat gruel in solution. The clear solution obtained in this way is therapeutically valuable and particularly suitable for lumbar anesthesia.
CH175921D 1931-12-17 1932-12-15 Process for the preparation of stable solutions of a salt of 4-B-methoxyethylaminobenzoic acid-B-diethylaminoethyl ester. CH175921A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE175921X 1931-12-17
CH168282T 1932-12-15

Publications (1)

Publication Number Publication Date
CH175921A true CH175921A (en) 1935-03-15

Family

ID=25718555

Family Applications (1)

Application Number Title Priority Date Filing Date
CH175921D CH175921A (en) 1931-12-17 1932-12-15 Process for the preparation of stable solutions of a salt of 4-B-methoxyethylaminobenzoic acid-B-diethylaminoethyl ester.

Country Status (1)

Country Link
CH (1) CH175921A (en)

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