CH155685A - Process for the preparation of a water-soluble antimony salt. - Google Patents

Process for the preparation of a water-soluble antimony salt.

Info

Publication number
CH155685A
CH155685A CH155685DA CH155685A CH 155685 A CH155685 A CH 155685A CH 155685D A CH155685D A CH 155685DA CH 155685 A CH155685 A CH 155685A
Authority
CH
Switzerland
Prior art keywords
water
preparation
solution
soluble
antimony salt
Prior art date
Application number
Other languages
German (de)
Inventor
Sandoz Chemische Fabri Vormals
Original Assignee
Chem Fab Vormals Sandoz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Fab Vormals Sandoz filed Critical Chem Fab Vormals Sandoz
Publication of CH155685A publication Critical patent/CH155685A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Darstellung eines wasserlöslichen     Antimonsalzes.       Das vorliegende Verfahren betrifft die  Darstellung von bis jetzt unbekanntem Na  triumantimonyl-V-gluconat und ist dadurch  gekennzeichnet, dass man     Antimonsäure.          Gluconsäure    und     Natriumhydroxyd    in Lö  sung aufeinander einwirken lässt.  



  Die neue Verbindung soll zu therapeu  tischen Zwecken Verwendung finden.  <I>Beispiel:</I>  Eine Lösung von 20     gr        Natriumgluconat,     dargestellt durch Neutralisieren von     Glucon-          säure    mit Natronlauge, in 40 cm' Wasser  wird auf dem Dampfbad mit -25     gr        Anti-          monsäure,    die durch Zersetzen von     Antimon-          pentachlorid    mit Wasser erhalten wurde, be  handelt. Es entsteht eine trübe Lösung,  welche durch Zentrifugieren und     Filtrieren          geklärt    wird.

   Aus     dieser    Lösung wird durch  Versetzen mit viel Methylalkohol (etwa  300 cm')     Natriumantimonyl-V-gluconat    in  Form eines farblosen Pulvers ausgeschieden.  



  Das ausgeschiedene,     mit        Methylalkohol     und Äther gewaschene und hierauf getrock-         nete    Pulver ist nicht hygroskopisch und in  Wasser leicht löslich. Säuren und Alkalien  fällen auch in der Siedehitze keine unlös  lichen Produkte aus.     Schwefelwasserstoff     fällt rotes     Antimonsulfid.  



  Process for the preparation of a water-soluble antimony salt. The present method relates to the preparation of previously unknown sodium antimonyl V-gluconate and is characterized in that one antimonic acid. Lets gluconic acid and sodium hydroxide interact in solution.



  The new connection is intended to be used for therapeutic purposes. <I> Example: </I> A solution of 20 grams of sodium gluconate, represented by neutralizing gluconic acid with caustic soda, in 40 cm 'of water is poured on the steam bath with -25 grams of antimonic acid, which is produced by the decomposition of antimony pentachloride was obtained with water, be treated. A cloudy solution is created, which is clarified by centrifugation and filtration.

   Sodium antimonyl V-gluconate is excreted in the form of a colorless powder from this solution by adding a lot of methyl alcohol (about 300 cm ').



  The precipitated powder, washed with methyl alcohol and ether and then dried, is not hygroscopic and easily soluble in water. Acids and alkalis do not precipitate any insoluble products, even at the boiling point. Hydrogen sulfide precipitates red antimony sulfide.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung von halt barem, klarlöslichem, bis jetzt unbekannten Natriumantimonyl-V-gluconat, dadurch ge kennzeichnet, dass man Antimonsäure, Glu- consäure und Natriumhydroxyd in Lösung aufeinander einwirken lässt. Die aus der Lösung isolierte Verbindung stellt ein farbloses, nicht hygroskopisches Pulver dar, das in Wasser leicht löslich ist und beständige Lösungen bildet. Säuren und Alkalien fällen auch in der Siedehitze keine unlöslichen Produkte aus. PATENT CLAIM: Process for the preparation of stable, clearly soluble, hitherto unknown sodium antimonyl V-gluconate, characterized in that antimonic acid, gluconic acid and sodium hydroxide are allowed to act on one another in solution. The compound isolated from the solution is a colorless, non-hygroscopic powder that is easily soluble in water and forms stable solutions. Acids and alkalis do not precipitate any insoluble products even at the boiling point. Schwefel wasserstoff fällt rotes Antimonsulfid. Die Verbindung soll in der Therapie Ver wendung finden. Hydrogen sulfide precipitates red antimony sulfide. The connection is intended to be used in therapy.
CH155685D 1929-11-26 1931-07-01 Process for the preparation of a water-soluble antimony salt. CH155685A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH148102T 1929-11-26
CH155685T 1931-07-01

Publications (1)

Publication Number Publication Date
CH155685A true CH155685A (en) 1932-06-30

Family

ID=25715125

Family Applications (1)

Application Number Title Priority Date Filing Date
CH155685D CH155685A (en) 1929-11-26 1931-07-01 Process for the preparation of a water-soluble antimony salt.

Country Status (1)

Country Link
CH (1) CH155685A (en)

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