CH151887A - Process for the preparation of 4-glycolylamino-4'-amino-arsenobenzene. - Google Patents

Process for the preparation of 4-glycolylamino-4'-amino-arsenobenzene.

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Publication number
CH151887A
CH151887A CH151887DA CH151887A CH 151887 A CH151887 A CH 151887A CH 151887D A CH151887D A CH 151887DA CH 151887 A CH151887 A CH 151887A
Authority
CH
Switzerland
Prior art keywords
glycolylamino
preparation
arsenobenzene
amino
solution
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH151887A publication Critical patent/CH151887A/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

      Verfahren    zur Darstellung von     4-Glykolylamino-4'-amino-arsenobenzol.       Gegenstand dieses Patentes ist ein Ver  fahren zur Darstellung von     4-(älykolylainino-          4'-aminoarsenobenzol,    welches dadurch gekenn  zeichnet ist, dass man     4-Glykolylamiriobenzol-          1-arsin    mit     4-Aminobenzol-l-arsiriogyd    kon  densiert.  



  Das bisher nicht bekannte Endprodukt ist  ein hellbraunes Pulver. Es zeichnet sich durch  geringe Giftigkeit und hohen Heilwert aus.  <I>Beispiel:</I>  55     gr        4-Glykolylaminobenzol-l-arsinsäure          werden    in 500     cm,'        Alethylalkohol    gelöst.

    Nach Zugabe von 300     gr    Zinkstaub lässt man  tropfenweise 1 1 konzentrierte Salzsäure unter  Rühren und Einleiten von Stickstoff     zutropfen,     wobei durch entsprechende     Kühlung    auf 20  bis 25   eine     Verseifung    der     Acylgruppe    ver  hindert wird.     Klan    rührt nach bis fast alles  Zink gelöst     iat,    saugt ab und     äthert    das Fil  trat aus. Die ätherische     Lösung    wird mit  2     n    Natronlauge ausgeschüttelt, die alkalisch  wässerige Lösung mit Salzsäure kongosauer    gemacht und filtriert.

   Zu dem Filtrat gibt  man eine Lösung von 30     gr        4-Aminobenzol-          1-arsinoxyd    in 200     em3    n/10 Salzsäure und  lässt unter Rühren 2 n     Natriumacetatlösung     bis zur kongoneutralen Reaktion zufliessen.  Hierbei scheidet sich das     4-Glykolylamino-          4'-aininoarsenobenzol    als hellbraunes Pulver  ab, das abgesaugt und ausgewaschen wird.  Ausbeute 53     gr.  



      Process for the preparation of 4-glycolylamino-4'-amino-arsenobenzene. The subject of this patent is a process for the preparation of 4- (alykolylainino-4'-aminoarsenobenzene, which is characterized in that 4-glycolylamiriobenzene-1-arsine is condensed with 4-aminobenzene-1-arsiriogyd.



  The previously unknown end product is a light brown powder. It is characterized by low toxicity and high healing value. <I> Example: </I> 55 grams of 4-glycolylaminobenzene-l-arsinic acid are dissolved in 500 cm of alcohol.

    After adding 300 g of zinc dust, 1 liter of concentrated hydrochloric acid is added dropwise with stirring and introduction of nitrogen, with saponification of the acyl group being prevented by appropriate cooling to 20 to 25. Klan stirs until almost all of the zinc is dissolved, sucks off and ether comes out. The ethereal solution is extracted with 2N sodium hydroxide solution, the alkaline aqueous solution is made Congo acidic with hydrochloric acid and filtered.

   A solution of 30 g of 4-aminobenzene-1-arsine oxide in 200 em3 N / 10 hydrochloric acid is added to the filtrate and 2 N sodium acetate solution is allowed to flow in with stirring until a congo-neutral reaction is obtained. The 4-glycolylamino-4'-aininoarsenobenzene separates out as a light brown powder, which is filtered off with suction and washed out. Yield 53 gr.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung von 4-Glykolyl- amino-4'-aminoarsenobenzol, dadurch gekenn zeichnet, dass man 4 - Glykolylamiriobenzol- arsin mit 4-Aminoberizolarsinoxyd konden siert. Das Endprodukt ist ein hellbraunes Pul ver. Es zeichnet sich durch geringe Giftigkeit und hohen Heilwert aus. PATENT CLAIM: Process for the preparation of 4-glycolylamino-4'-aminoarsenobenzene, characterized in that 4-glycolylamiriobenzolarsine is condensed with 4-aminoberizolarsinoxide. The end product is a light brown powder. It is characterized by its low toxicity and high healing value.
CH151887D 1929-08-27 1930-08-08 Process for the preparation of 4-glycolylamino-4'-amino-arsenobenzene. CH151887A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE151887X 1929-08-27
CH149252T 1930-08-08

Publications (1)

Publication Number Publication Date
CH151887A true CH151887A (en) 1931-12-31

Family

ID=25715381

Family Applications (1)

Application Number Title Priority Date Filing Date
CH151887D CH151887A (en) 1929-08-27 1930-08-08 Process for the preparation of 4-glycolylamino-4'-amino-arsenobenzene.

Country Status (1)

Country Link
CH (1) CH151887A (en)

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