CH151076A - Process for the preparation of 4-glycolylamino-3'-amino-4'-oxyarsenobenzene-formaldehyde bisulfite. - Google Patents
Process for the preparation of 4-glycolylamino-3'-amino-4'-oxyarsenobenzene-formaldehyde bisulfite.Info
- Publication number
- CH151076A CH151076A CH151076DA CH151076A CH 151076 A CH151076 A CH 151076A CH 151076D A CH151076D A CH 151076DA CH 151076 A CH151076 A CH 151076A
- Authority
- CH
- Switzerland
- Prior art keywords
- preparation
- amino
- oxyarsenobenzene
- glycolylamino
- formaldehyde bisulfite
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
Verfahren zur Darstellung von 4-Glykolylaminö-3'-amino-4'-ogyarsenobenzol- formaldehydbisulfit. Es wurde gefunden, dass die Forma:lde- hydbisulfitverbindungen asymmetrischer Ar- senobenzole, die durch Reduktion eines Ge misches von Glykolylaminoarylarsinsäuren der allgemeinen Formel:
EMI0001.0011
und Arylarsinsäuren der allgemeinen Formel Aryl - As O(Oll)2 erhalten werden, sich zur Bekämpfung von Spirochäten- und Trypanosomenerkrankungen ganz besonders eignen. Vor den bekannten Arsenobenzolen, die als Heilmittel Verwen dung finden, zeichnen sich diese Verbindun gen durch absolut reizlose Verträglichkeit aus und dadurch, dass sie sowohl subkutan, als auch intravenös injiziert werden können.
Gegenstand der vorliegenden Erfindung ist ein Verfahren zur Darstellung von 4- Glykolylamino - 3' - amino - 4' - ogyarseno- benzolformaldehydbisulfit, welches dadurch gekennzeichnet ist, dass man 4-Glykolyl- amino - '3' - amino - 4' - oxyarsenobenzol mit Formaldehydbisulfit umsetzt.
Das Präparat ist ein gelbes, in Wasser leicht lösliches Pulver.
<I>Beispiel:</I> 15 -r 4 - Glyko:lylamino - 3' - amino - 4'- oxyarsenobenzol - natrium ( erhältlich nach s.ehweiz. Patent Nr. 144432) werden in 60 cm' Wasser gelöst und 4,5 g-f Formal- dehydbisulfitnatrium gelöst in 5 cm' Was ser, zugegeben.
Sobald eine entnommene Probe kohlensäurebeständig ist, wird die Lösung durch Kohlensäure und dann mit- telst 2n-Salzsäure auf lackmusneutral abge stumpft. Durch Eingiessen in ein Gemisch von 10 Teilen Alkohol und 1 Teil Äther wird das feste Präparat abgeschieden, abge saugt, mit Alkohol und Äther gewaschen und im Vakuum getrocknet. Das Präparat ist ein gelbes, in Wasser leicht lösliches Pulver.
Process for the preparation of 4-glycolylamino-3'-amino-4'-ogyarsenobenzene-formaldehyde bisulfite. It has been found that the form: ldehydbisulfitverbindungen asymmetric arsenobenzenes, which are obtained by reducing a mixture of glycolylaminoarylarsinic acids of the general formula:
EMI0001.0011
and aryl arsinic acids of the general formula Aryl - As O (OII) 2 are obtained, are very particularly suitable for combating spirochete and trypanosomal diseases. Before the well-known arsenobenzenes, which are used as medicinal products, these compounds are characterized by their absolutely irritant-free tolerance and the fact that they can be injected both subcutaneously and intravenously.
The present invention relates to a process for the preparation of 4-glycolylamino - 3 '- amino - 4' - ogyarsenobenzene formaldehyde bisulfite, which is characterized in that 4-glycolylamino - '3' - amino - 4 '- oxyarsenobenzene is used Formaldehyde bisulfite converts.
The preparation is a yellow powder that is easily soluble in water.
<I> Example: </I> 15 -r 4 - Glyko: lylamino - 3 '- amino - 4'- oxyarsenobenzene - sodium (available according to Swiss Patent No. 144432) are dissolved in 60 cm' of water and 4 , 5 gf formaldehyde bisulfite sodium dissolved in 5 cm water was added.
As soon as a sample taken is carbonic acid-resistant, the solution is blunted to litmus-neutral by carbonic acid and then using 2N hydrochloric acid. The solid preparation is deposited by pouring into a mixture of 10 parts of alcohol and 1 part of ether, suctioned off, washed with alcohol and ether and dried in vacuo. The preparation is a yellow powder that is easily soluble in water.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE151076X | 1929-08-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH151076A true CH151076A (en) | 1931-11-30 |
Family
ID=5674275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH151076D CH151076A (en) | 1929-08-24 | 1930-08-06 | Process for the preparation of 4-glycolylamino-3'-amino-4'-oxyarsenobenzene-formaldehyde bisulfite. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH151076A (en) |
-
1930
- 1930-08-06 CH CH151076D patent/CH151076A/en unknown
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