CA943128A - Penicillins, their preparation and their pharmaceutical use - Google Patents

Penicillins, their preparation and their pharmaceutical use

Info

Publication number
CA943128A
CA943128A CA113,784A CA113784A CA943128A CA 943128 A CA943128 A CA 943128A CA 113784 A CA113784 A CA 113784A CA 943128 A CA943128 A CA 943128A
Authority
CA
Canada
Prior art keywords
penicillins
preparation
pharmaceutical use
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA113,784A
Other languages
English (en)
Other versions
CA113784S (en
Inventor
Hans-Bodo Konig
Karl G. Metzger
Wilfried Schrock
Hans Disselnkofter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2025414A external-priority patent/DE2025414C3/de
Priority claimed from DE19712104580 external-priority patent/DE2104580C3/de
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of CA943128A publication Critical patent/CA943128A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
    • C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
    • C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
    • C07D499/68—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with aromatic rings as additional substituents on the carbon chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA113,784A 1970-05-25 1971-05-25 Penicillins, their preparation and their pharmaceutical use Expired CA943128A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2025414A DE2025414C3 (de) 1970-05-25 1970-05-25 Cyclische Acylureidophenylacetamidopenicillansäuren
DE19712104580 DE2104580C3 (de) 1971-02-01 1971-02-01 Acylureidopenicilline

Publications (1)

Publication Number Publication Date
CA943128A true CA943128A (en) 1974-03-05

Family

ID=25759178

Family Applications (1)

Application Number Title Priority Date Filing Date
CA113,784A Expired CA943128A (en) 1970-05-25 1971-05-25 Penicillins, their preparation and their pharmaceutical use

Country Status (28)

Country Link
JP (1) JPS5538357B1 (fr)
AR (2) AR195267A1 (fr)
AT (1) AT307617B (fr)
BE (1) BE767647A (fr)
BG (1) BG23220A3 (fr)
CA (1) CA943128A (fr)
CH (1) CH562249A5 (fr)
CS (1) CS171230B2 (fr)
CY (1) CY829A (fr)
DD (1) DD91497B3 (fr)
DK (1) DK133679C (fr)
EG (1) EG10856A (fr)
ES (4) ES391532A1 (fr)
FI (1) FI54484C (fr)
FR (1) FR2100681B1 (fr)
GB (1) GB1301961A (fr)
HU (1) HU162205B (fr)
IE (1) IE35311B1 (fr)
IL (1) IL36905A (fr)
KE (1) KE2592A (fr)
LU (1) LU63203A1 (fr)
NL (1) NL172660C (fr)
NO (1) NO141164C (fr)
PH (1) PH14794A (fr)
RO (2) RO59157A (fr)
SE (1) SE395896B (fr)
SU (1) SU472507A3 (fr)
YU (1) YU130271A (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2354219A1 (de) * 1973-10-30 1975-05-07 Bayer Ag Beta-lactam-antibiotica, ein verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4039673A (en) 1973-10-30 1977-08-02 Bayer Aktiengesellschaft Penicillins and cephalosporins and their production
GB1486349A (en) * 1974-11-28 1977-09-21 Bayer Ag Beta-lactam antibiotics process for their preparation and their use as medicaments
DE2658906A1 (de) * 1976-12-24 1978-07-06 Bayer Ag Beta-lactam-antibiotika, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
GB1584400A (en) * 1976-12-24 1981-02-11 Bayer Ag (2-oxo-imidazoliden-1-yl(carbonylamino)-acetamido-cephalosporins and penicillins
CA1133896A (fr) * 1978-05-26 1982-10-19 Nobuhiro Oi Derive de l'acide penicillanique et procede de preparation
JPS5732289A (en) 1980-08-05 1982-02-20 Chugai Pharmaceut Co Ltd Alpha-substituted ureidobenzylpenicillin

Also Published As

Publication number Publication date
YU130271A (en) 1982-02-25
GB1301961A (fr) 1973-01-04
AR195267A1 (es) 1973-09-28
IL36905A (en) 1975-11-25
CH562249A5 (fr) 1975-05-30
AT307617B (de) 1973-05-25
ES403124A1 (es) 1976-01-01
LU63203A1 (fr) 1971-09-01
NL7107175A (fr) 1971-11-29
DK133679C (da) 1976-11-15
DK133679B (da) 1976-06-28
FI54484C (fi) 1978-12-11
HU162205B (fr) 1973-01-29
IE35311L (en) 1971-11-25
IL36905A0 (en) 1971-07-28
ES403126A1 (es) 1975-05-01
RO59157A (fr) 1976-04-15
SE395896B (sv) 1977-08-29
SU472507A3 (ru) 1975-05-30
AR195946A1 (es) 1973-11-15
EG10856A (en) 1977-05-31
FR2100681B1 (fr) 1974-10-18
NO141164C (no) 1980-01-23
ES403125A1 (es) 1975-12-16
NL172660B (nl) 1983-05-02
CY829A (en) 1976-03-19
BE767647A (fr) 1971-11-25
ES391532A1 (es) 1974-10-01
DD91497A5 (de) 1972-07-20
IE35311B1 (en) 1976-01-07
NL172660C (nl) 1983-10-03
NO141164B (no) 1979-10-15
PH14794A (en) 1981-12-09
RO62689A (fr) 1978-05-15
KE2592A (en) 1976-01-09
CS171230B2 (fr) 1976-10-29
DD91497B3 (de) 1988-01-27
JPS5538357B1 (fr) 1980-10-03
FR2100681A1 (fr) 1972-03-24
BG23220A3 (fr) 1977-07-12
FI54484B (fi) 1978-08-31

Similar Documents

Publication Publication Date Title
AU462239B2 (en) New phenyl-imidazolyl-alkanyl derivatives, their production and their pharmaceutical use
CA939343A (en) Imines, their preparation, and their pharmaceutical use
CA1000713A (en) Aminophenylamidines, their production and their pharmaceutical use
CA930365A (en) Aminophenylamidines, their production and their medicinal use
CA942312A (en) Aminophenyl-cycloamidines, their production and their medicinal use
AU456174B2 (en) Pharmaceutical preparation
CA943128A (en) Penicillins, their preparation and their pharmaceutical use
CA1007638A (en) Phenylimino-3-aza-1-thia-cycloalkanes, their preparation, and their medicinal use
CA932722A (en) Penicillins, their preparation and their use
AU465597B2 (en) Azetidinane derivatives and their preparation
ZA713274B (en) New penicillins,their preparation and their use
CA967151A (en) Nitrodiphenylamines, their manufacture and use
ZA713371B (en) New penicillins,their preparation and their pharmaceutical use
AU456701B2 (en) New substituted propynes, their production, and their pharmaceutical and veterinary use
AU450701B2 (en) New cycloalkano-quinolone derivatives and the preparation thereof
IL37124A0 (en) Halogeno-carbonyl penicillin derivatives,and their preparation
AU3041671A (en) Pharmaceutical preparation
AU462830B2 (en) Substituted imidzoles, their preparations and pharmaceutical use
CA842841A (en) 6-diloweralkylamino-fluoran derivatives and their preparation and use
AU2604271A (en) Substituted imidzoles, their preparations and pharmaceutical use
AU448290B2 (en) New aminophenylamidines, their production and their medicinal use
CA855186A (en) Pharmaceutical preparation
AU450323B2 (en) New aminophenylamidines their production and their pharmaceutical use
AU426837B2 (en) New substituted quinoxaline-di-n-oxides, their preparation, and their pharmaceutical use
CA845725A (en) Heterocyclic compounds, their preparation and use