CA3227475A1 - Use of mesenchymal stem cells in treatment of juvenile hypoplastic left heart syndrome - Google Patents

Use of mesenchymal stem cells in treatment of juvenile hypoplastic left heart syndrome Download PDF

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Publication number
CA3227475A1
CA3227475A1 CA3227475A CA3227475A CA3227475A1 CA 3227475 A1 CA3227475 A1 CA 3227475A1 CA 3227475 A CA3227475 A CA 3227475A CA 3227475 A CA3227475 A CA 3227475A CA 3227475 A1 CA3227475 A1 CA 3227475A1
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CA
Canada
Prior art keywords
patient
administration
change
stem cells
mesenchymal stem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3227475A
Other languages
English (en)
French (fr)
Inventor
Joshua M. Hare
Sunjay Kaushal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Longeveron Inc
Original Assignee
Longeveron Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Longeveron Inc filed Critical Longeveron Inc
Publication of CA3227475A1 publication Critical patent/CA3227475A1/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A61B5/029—Measuring blood output from the heart, e.g. minute volume
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Physiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA3227475A 2021-07-26 2022-07-26 Use of mesenchymal stem cells in treatment of juvenile hypoplastic left heart syndrome Pending CA3227475A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163203519P 2021-07-26 2021-07-26
US63/203,519 2021-07-26
PCT/US2022/038370 WO2023009537A1 (en) 2021-07-26 2022-07-26 Use of mesenchymal stem cells in treatment of juvenile hypoplastic left heart syndrome

Publications (1)

Publication Number Publication Date
CA3227475A1 true CA3227475A1 (en) 2023-02-02

Family

ID=83049982

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3227475A Pending CA3227475A1 (en) 2021-07-26 2022-07-26 Use of mesenchymal stem cells in treatment of juvenile hypoplastic left heart syndrome

Country Status (9)

Country Link
US (1) US20240350549A1 (https=)
EP (1) EP4376950A1 (https=)
JP (1) JP2024527034A (https=)
KR (1) KR20240040776A (https=)
CN (1) CN117999082A (https=)
AU (1) AU2022316959A1 (https=)
CA (1) CA3227475A1 (https=)
TW (1) TW202321437A (https=)
WO (1) WO2023009537A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025062365A1 (en) * 2023-09-22 2025-03-27 Mesoblast International Sárl Mesenchymal lineage precursor or stem cells (mlpscs) for use in methods of treating congenital heart disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180105705A (ko) 2016-02-04 2018-09-28 롱에버론 엘엘씨 백신 보조제로서의 중간엽 줄기 세포 및 그의 사용 방법
JP7276664B2 (ja) 2016-11-11 2023-05-18 ロングエバーオン インコーポレイテッド 細胞性及び体液性免疫を達成するためのヒト間葉系幹細胞を使用する方法
SG11201912209UA (en) 2017-06-19 2020-01-30 Longeveron Llc Treatment of sexual dysfunction and improvement in sexual quality of life
AU2020356193A1 (en) * 2019-09-24 2022-05-19 Children's Hospital Of Philadelphia Methods of improving exercise performance, single ventricular performance, and myocardial performance index (MPI) in single ventricle heart disease, using udenafil compositions

Also Published As

Publication number Publication date
TW202321437A (zh) 2023-06-01
KR20240040776A (ko) 2024-03-28
CN117999082A (zh) 2024-05-07
WO2023009537A1 (en) 2023-02-02
AU2022316959A1 (en) 2024-02-29
EP4376950A1 (en) 2024-06-05
JP2024527034A (ja) 2024-07-19
US20240350549A1 (en) 2024-10-24

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