CA3214084A1 - Prodrugs of kv7 channel openers - Google Patents
Prodrugs of kv7 channel openers Download PDFInfo
- Publication number
- CA3214084A1 CA3214084A1 CA3214084A CA3214084A CA3214084A1 CA 3214084 A1 CA3214084 A1 CA 3214084A1 CA 3214084 A CA3214084 A CA 3214084A CA 3214084 A CA3214084 A CA 3214084A CA 3214084 A1 CA3214084 A1 CA 3214084A1
- Authority
- CA
- Canada
- Prior art keywords
- depression
- disorder
- compound
- disorders
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163163470P | 2021-03-19 | 2021-03-19 | |
| US63/163,470 | 2021-03-19 | ||
| PCT/US2022/021057 WO2022198114A1 (en) | 2021-03-19 | 2022-03-20 | Prodrugs of kv7 channel openers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3214084A1 true CA3214084A1 (en) | 2022-09-22 |
Family
ID=83321210
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3214084A Pending CA3214084A1 (en) | 2021-03-19 | 2022-03-20 | Prodrugs of kv7 channel openers |
| CA3214270A Pending CA3214270A1 (en) | 2021-03-19 | 2022-03-20 | Prodrugs of kv7 channel openers |
| CA3214305A Pending CA3214305A1 (en) | 2021-03-19 | 2022-03-20 | Prodrugs of kv7 channel openers |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3214270A Pending CA3214270A1 (en) | 2021-03-19 | 2022-03-20 | Prodrugs of kv7 channel openers |
| CA3214305A Pending CA3214305A1 (en) | 2021-03-19 | 2022-03-20 | Prodrugs of kv7 channel openers |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20240300894A1 (OSRAM) |
| EP (3) | EP4308544A4 (OSRAM) |
| JP (2) | JP2024511057A (OSRAM) |
| KR (2) | KR20230159506A (OSRAM) |
| CN (3) | CN117295711A (OSRAM) |
| AU (3) | AU2022237675A1 (OSRAM) |
| BR (2) | BR112023019074A2 (OSRAM) |
| CA (3) | CA3214084A1 (OSRAM) |
| IL (2) | IL306005A (OSRAM) |
| MX (2) | MX2023010978A (OSRAM) |
| WO (3) | WO2022198116A1 (OSRAM) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115364229B (zh) * | 2022-09-26 | 2024-02-20 | 江苏海洋大学 | 一种用于预防或治疗疼痛的药物组合物 |
| CN118553447B (zh) * | 2024-07-30 | 2024-11-08 | 四川大学华西医院 | 动态惊恐障碍治疗方案推荐系统、治疗系统及存储介质 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4200259A1 (de) * | 1992-01-08 | 1993-07-15 | Asta Medica Ag | Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung |
| JP2004115450A (ja) * | 2002-09-27 | 2004-04-15 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
| US20060004197A1 (en) * | 2004-07-02 | 2006-01-05 | Thomas Thrash | Sulfonamide-based compounds as protein tyrosine kinase inhibitors |
| US20090118285A1 (en) * | 2006-02-07 | 2009-05-07 | H. Lundbeck A/S | Use of kcnq-openers for treating or reducing the symptoms of schizophrenia |
| AU2009270768A1 (en) * | 2008-07-18 | 2010-01-21 | Valeant Pharmaceuticals International | Modified release formulation and methods of use |
| GB0813403D0 (en) * | 2008-07-22 | 2008-08-27 | Lectus Therapeutics Ltd | Potassium ion channel modulators & uses thereof |
| CN103073455B (zh) * | 2011-10-25 | 2015-08-19 | 中国科学院上海药物研究所 | 一类新型的kcnq钾通道激动剂、其制备方法和用途 |
| WO2013179298A2 (en) * | 2012-04-23 | 2013-12-05 | Cadila Healthcare Limited | A process for preparation of phenyl carbamate derivative and polymorphic forms thereof |
| US10526280B2 (en) * | 2014-11-13 | 2020-01-07 | University of Pittsburgh—of the Commonwealth System of Higher Education | (2-amino-4-(arylamino)phenyl carbamates |
| MX2018015251A (es) * | 2016-06-10 | 2019-04-25 | Scifluor Life Sciences Inc | Derivados de 2-amino-4-(amino sustituido)fenil carbamato fluorinado. |
| WO2020047603A1 (en) * | 2018-09-06 | 2020-03-12 | Monash University | Method of treating a sleep breathing disorder |
-
2022
- 2022-03-20 US US18/282,934 patent/US20240300894A1/en active Pending
- 2022-03-20 IL IL306005A patent/IL306005A/en unknown
- 2022-03-20 WO PCT/US2022/021059 patent/WO2022198116A1/en not_active Ceased
- 2022-03-20 EP EP22772332.7A patent/EP4308544A4/en active Pending
- 2022-03-20 CA CA3214084A patent/CA3214084A1/en active Pending
- 2022-03-20 MX MX2023010978A patent/MX2023010978A/es unknown
- 2022-03-20 CA CA3214270A patent/CA3214270A1/en active Pending
- 2022-03-20 IL IL306004A patent/IL306004A/en unknown
- 2022-03-20 EP EP22772331.9A patent/EP4308543A4/en active Pending
- 2022-03-20 WO PCT/US2022/021058 patent/WO2022198115A1/en not_active Ceased
- 2022-03-20 JP JP2023557407A patent/JP2024511057A/ja active Pending
- 2022-03-20 AU AU2022237675A patent/AU2022237675A1/en active Pending
- 2022-03-20 MX MX2023010976A patent/MX2023010976A/es unknown
- 2022-03-20 JP JP2023557288A patent/JP2024511997A/ja active Pending
- 2022-03-20 CN CN202280034079.2A patent/CN117295711A/zh active Pending
- 2022-03-20 AU AU2022240779A patent/AU2022240779A1/en active Pending
- 2022-03-20 CN CN202280034756.0A patent/CN117321031A/zh active Pending
- 2022-03-20 CA CA3214305A patent/CA3214305A1/en active Pending
- 2022-03-20 BR BR112023019074A patent/BR112023019074A2/pt unknown
- 2022-03-20 BR BR112023019077A patent/BR112023019077A2/pt unknown
- 2022-03-20 KR KR1020237035629A patent/KR20230159506A/ko active Pending
- 2022-03-20 CN CN202280034761.1A patent/CN117355503A/zh active Pending
- 2022-03-20 WO PCT/US2022/021057 patent/WO2022198114A1/en not_active Ceased
- 2022-03-20 AU AU2022239618A patent/AU2022239618A1/en active Pending
- 2022-03-20 EP EP22772333.5A patent/EP4308545A4/en active Pending
- 2022-03-20 KR KR1020237035814A patent/KR20230159531A/ko active Pending
- 2022-03-20 US US18/282,940 patent/US20240228434A1/en active Pending
- 2022-03-20 US US18/282,943 patent/US20240208896A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20230159531A (ko) | 2023-11-21 |
| JP2024511057A (ja) | 2024-03-12 |
| BR112023019074A2 (pt) | 2023-12-05 |
| IL306004A (en) | 2023-11-01 |
| US20240228434A1 (en) | 2024-07-11 |
| MX2023010978A (es) | 2023-12-07 |
| CN117295711A (zh) | 2023-12-26 |
| EP4308545A1 (en) | 2024-01-24 |
| JP2024511997A (ja) | 2024-03-18 |
| EP4308543A1 (en) | 2024-01-24 |
| CN117321031A (zh) | 2023-12-29 |
| WO2022198114A1 (en) | 2022-09-22 |
| EP4308544A4 (en) | 2025-04-30 |
| MX2023010976A (es) | 2023-12-07 |
| WO2022198116A9 (en) | 2022-10-27 |
| US20240300894A1 (en) | 2024-09-12 |
| CA3214305A1 (en) | 2022-09-22 |
| US20240208896A1 (en) | 2024-06-27 |
| WO2022198116A8 (en) | 2023-11-09 |
| WO2022198116A1 (en) | 2022-09-22 |
| EP4308543A4 (en) | 2025-04-30 |
| IL306005A (en) | 2023-11-01 |
| AU2022239618A1 (en) | 2023-10-05 |
| EP4308545A4 (en) | 2025-04-30 |
| CN117355503A (zh) | 2024-01-05 |
| CA3214270A1 (en) | 2022-09-22 |
| WO2022198115A1 (en) | 2022-09-22 |
| EP4308544A1 (en) | 2024-01-24 |
| AU2022240779A1 (en) | 2023-10-12 |
| AU2022237675A1 (en) | 2023-10-12 |
| BR112023019077A2 (pt) | 2023-12-05 |
| KR20230159506A (ko) | 2023-11-21 |
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