CA3209781A1 - Utilisation de luvadaxistat pour le traitement d'une deficience cognitive - Google Patents
Utilisation de luvadaxistat pour le traitement d'une deficience cognitive Download PDFInfo
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- CA3209781A1 CA3209781A1 CA3209781A CA3209781A CA3209781A1 CA 3209781 A1 CA3209781 A1 CA 3209781A1 CA 3209781 A CA3209781 A CA 3209781A CA 3209781 A CA3209781 A CA 3209781A CA 3209781 A1 CA3209781 A1 CA 3209781A1
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- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- JTJMJGYZQZDUJJ-UHFFFAOYSA-N phencyclidine Chemical compound C1CCCCN1C1(C=2C=CC=CC=2)CCCCC1 JTJMJGYZQZDUJJ-UHFFFAOYSA-N 0.000 description 1
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- 230000006461 physiological response Effects 0.000 description 1
- 229940075930 picrate Drugs 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-M picrate anion Chemical compound [O-]C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-M 0.000 description 1
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- 229960001860 salicylate Drugs 0.000 description 1
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- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
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- 238000012453 sprague-dawley rat model Methods 0.000 description 1
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- 239000012730 sustained-release form Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 210000000225 synapse Anatomy 0.000 description 1
- 230000005062 synaptic transmission Effects 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
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- 210000001519 tissue Anatomy 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
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- 238000012384 transportation and delivery Methods 0.000 description 1
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical class CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
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- 230000004584 weight gain Effects 0.000 description 1
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- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne des procédés de traitement d'au moins un symptôme cognitif, par exemple, au moins un symptôme cognitif associé à la schizophrénie, comprenant l'administration d'au moins un composé choisi parmi le composé (I) et des sels pharmaceutiquement acceptables de celui-ci. L'invention concerne également des procédés pour augmenter les taux de D-sérine, la plasticité synaptique et/ou la potentialisation à long terme, comprenant l'administration d'au moins un composé choisi parmi le composé (I) et des sels pharmaceutiquement acceptables de celui-ci.
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163200327P | 2021-03-01 | 2021-03-01 | |
| US63/200,327 | 2021-03-01 | ||
| US202163229945P | 2021-08-05 | 2021-08-05 | |
| US63/229,945 | 2021-08-05 | ||
| US202163264747P | 2021-12-01 | 2021-12-01 | |
| US63/264,747 | 2021-12-01 | ||
| US202163265628P | 2021-12-17 | 2021-12-17 | |
| US63/265,628 | 2021-12-17 | ||
| PCT/US2022/018112 WO2022187127A1 (fr) | 2021-03-01 | 2022-02-28 | Utilisation de luvadaxistat pour le traitement d'une déficience cognitive |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3209781A1 true CA3209781A1 (fr) | 2022-09-09 |
Family
ID=80780614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3209781A Pending CA3209781A1 (fr) | 2021-03-01 | 2022-02-28 | Utilisation de luvadaxistat pour le traitement d'une deficience cognitive |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP4301367A1 (fr) |
| JP (1) | JP2024508860A (fr) |
| KR (1) | KR20230154217A (fr) |
| AU (1) | AU2022228417A1 (fr) |
| CA (1) | CA3209781A1 (fr) |
| CL (1) | CL2023002558A1 (fr) |
| CO (1) | CO2023011625A2 (fr) |
| DO (1) | DOP2023000174A (fr) |
| EC (1) | ECSP23065907A (fr) |
| IL (1) | IL305210A (fr) |
| MX (1) | MX2023010140A (fr) |
| PE (1) | PE20232048A1 (fr) |
| TW (1) | TW202302109A (fr) |
| WO (1) | WO2022187127A1 (fr) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3115B1 (ar) | 2011-08-22 | 2017-09-20 | Takeda Pharmaceuticals Co | مركبات بيريدازينون واستخدامها كمثبطات daao |
| GB201403944D0 (en) | 2014-03-06 | 2014-04-23 | Takeda Pharmaceutical | New use |
-
2022
- 2022-02-28 KR KR1020237033260A patent/KR20230154217A/ko unknown
- 2022-02-28 MX MX2023010140A patent/MX2023010140A/es unknown
- 2022-02-28 IL IL305210A patent/IL305210A/en unknown
- 2022-02-28 AU AU2022228417A patent/AU2022228417A1/en active Pending
- 2022-02-28 CA CA3209781A patent/CA3209781A1/fr active Pending
- 2022-02-28 EP EP22710880.0A patent/EP4301367A1/fr active Pending
- 2022-02-28 PE PE2023002471A patent/PE20232048A1/es unknown
- 2022-02-28 JP JP2023552508A patent/JP2024508860A/ja active Pending
- 2022-02-28 WO PCT/US2022/018112 patent/WO2022187127A1/fr active Application Filing
- 2022-03-01 TW TW111107415A patent/TW202302109A/zh unknown
-
2023
- 2023-08-30 DO DO2023000174A patent/DOP2023000174A/es unknown
- 2023-08-30 CL CL2023002558A patent/CL2023002558A1/es unknown
- 2023-08-31 EC ECSENADI202365907A patent/ECSP23065907A/es unknown
- 2023-09-01 CO CONC2023/0011625A patent/CO2023011625A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DOP2023000174A (es) | 2024-01-31 |
| TW202302109A (zh) | 2023-01-16 |
| PE20232048A1 (es) | 2023-12-27 |
| KR20230154217A (ko) | 2023-11-07 |
| ECSP23065907A (es) | 2023-09-29 |
| EP4301367A1 (fr) | 2024-01-10 |
| WO2022187127A1 (fr) | 2022-09-09 |
| CO2023011625A2 (es) | 2023-12-11 |
| JP2024508860A (ja) | 2024-02-28 |
| IL305210A (en) | 2023-10-01 |
| AU2022228417A1 (en) | 2023-10-26 |
| MX2023010140A (es) | 2023-10-12 |
| CL2023002558A1 (es) | 2024-03-22 |
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