CA3192684A1 - Triphenyl calcilytic compounds for the treatment of autosomal dominant hypocalcemia type 1 (adh1) - Google Patents

Triphenyl calcilytic compounds for the treatment of autosomal dominant hypocalcemia type 1 (adh1)

Info

Publication number
CA3192684A1
CA3192684A1 CA3192684A CA3192684A CA3192684A1 CA 3192684 A1 CA3192684 A1 CA 3192684A1 CA 3192684 A CA3192684 A CA 3192684A CA 3192684 A CA3192684 A CA 3192684A CA 3192684 A1 CA3192684 A1 CA 3192684A1
Authority
CA
Canada
Prior art keywords
cltx
dosing
cca
blood
period
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3192684A
Other languages
English (en)
French (fr)
Inventor
Simon BRUCE
Jonathan Fox
Ramei SANI-GROSSO
Ali KOMEYLI
Ananth SRIDHAR
Mary Scott ROBERTS
Michael T. Collins
Rachel I. Gafni
Kelly B. L. Roszko
Iris R. Hartley
Karen A. Pozo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Calcilytix Therapeutics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA3192684A1 publication Critical patent/CA3192684A1/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
CA3192684A 2020-09-18 2021-09-16 Triphenyl calcilytic compounds for the treatment of autosomal dominant hypocalcemia type 1 (adh1) Pending CA3192684A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063080165P 2020-09-18 2020-09-18
US63/080,165 2020-09-18
US202163159397P 2021-03-10 2021-03-10
US63/159,397 2021-03-10
PCT/US2021/050677 WO2022060987A1 (en) 2020-09-18 2021-09-16 Triphenyl calcilytic compounds for the treatment of autosomal dominant hypocalcemia type 1 (adh1)

Publications (1)

Publication Number Publication Date
CA3192684A1 true CA3192684A1 (en) 2022-03-24

Family

ID=78087574

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3192684A Pending CA3192684A1 (en) 2020-09-18 2021-09-16 Triphenyl calcilytic compounds for the treatment of autosomal dominant hypocalcemia type 1 (adh1)

Country Status (10)

Country Link
US (1) US20220087961A1 (https=)
EP (1) EP4213829A1 (https=)
JP (1) JP2023542932A (https=)
KR (1) KR20230112609A (https=)
AU (1) AU2021343475A1 (https=)
CA (1) CA3192684A1 (https=)
IL (1) IL301409A (https=)
MX (1) MX2023003129A (https=)
TW (1) TW202227046A (https=)
WO (1) WO2022060987A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230106582A (ko) 2020-08-04 2023-07-13 캘시리틱스 테라퓨틱스, 인코포레이티드 트리페닐 칼실리틱 화합물의 제형
EP4698162A1 (en) * 2023-04-21 2026-02-25 Calcilytix Therapeutics, Inc. Treatment of hypoparathyroidism using triphenyl calcilytic compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0407097A (pt) * 2003-04-23 2006-01-24 Japan Tobacco Inc Antagonista do casr
KR20230106582A (ko) * 2020-08-04 2023-07-13 캘시리틱스 테라퓨틱스, 인코포레이티드 트리페닐 칼실리틱 화합물의 제형

Also Published As

Publication number Publication date
JP2023542932A (ja) 2023-10-12
KR20230112609A (ko) 2023-07-27
TW202227046A (zh) 2022-07-16
WO2022060987A1 (en) 2022-03-24
IL301409A (en) 2023-05-01
EP4213829A1 (en) 2023-07-26
AU2021343475A9 (en) 2024-05-02
US20220087961A1 (en) 2022-03-24
MX2023003129A (es) 2023-08-04
AU2021343475A1 (en) 2023-06-01

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