KR20230112609A - 상염색체 우성 저칼슘혈증 타입 1(adh1)의 치료를 위한 트리페닐 칼시라이틱 화합물 - Google Patents

상염색체 우성 저칼슘혈증 타입 1(adh1)의 치료를 위한 트리페닐 칼시라이틱 화합물 Download PDF

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Publication number
KR20230112609A
KR20230112609A KR1020237012476A KR20237012476A KR20230112609A KR 20230112609 A KR20230112609 A KR 20230112609A KR 1020237012476 A KR1020237012476 A KR 1020237012476A KR 20237012476 A KR20237012476 A KR 20237012476A KR 20230112609 A KR20230112609 A KR 20230112609A
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KR
South Korea
Prior art keywords
cltx
dose
cca
blood
total daily
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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KR1020237012476A
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English (en)
Korean (ko)
Inventor
시몬 브루스
조나단 폭스
라메이 사니-그로쏘
알리 코메일리
아난트 스리다르
매리 스콧 로버츠
마이클 티. 콜린스
레이첼 아이. 가프니
켈리 비. 엘. 로츠코
아이리스 알. 하틀리
카렌 에이. 포조
Original Assignee
캘시리틱스 테라퓨틱스, 인코포레이티드
더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈
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Application filed by 캘시리틱스 테라퓨틱스, 인코포레이티드, 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 filed Critical 캘시리틱스 테라퓨틱스, 인코포레이티드
Publication of KR20230112609A publication Critical patent/KR20230112609A/ko
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
KR1020237012476A 2020-09-18 2021-09-16 상염색체 우성 저칼슘혈증 타입 1(adh1)의 치료를 위한 트리페닐 칼시라이틱 화합물 Pending KR20230112609A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063080165P 2020-09-18 2020-09-18
US63/080,165 2020-09-18
US202163159397P 2021-03-10 2021-03-10
US63/159,397 2021-03-10
PCT/US2021/050677 WO2022060987A1 (en) 2020-09-18 2021-09-16 Triphenyl calcilytic compounds for the treatment of autosomal dominant hypocalcemia type 1 (adh1)

Publications (1)

Publication Number Publication Date
KR20230112609A true KR20230112609A (ko) 2023-07-27

Family

ID=78087574

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237012476A Pending KR20230112609A (ko) 2020-09-18 2021-09-16 상염색체 우성 저칼슘혈증 타입 1(adh1)의 치료를 위한 트리페닐 칼시라이틱 화합물

Country Status (10)

Country Link
US (1) US20220087961A1 (https=)
EP (1) EP4213829A1 (https=)
JP (1) JP2023542932A (https=)
KR (1) KR20230112609A (https=)
AU (1) AU2021343475A1 (https=)
CA (1) CA3192684A1 (https=)
IL (1) IL301409A (https=)
MX (1) MX2023003129A (https=)
TW (1) TW202227046A (https=)
WO (1) WO2022060987A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230106582A (ko) 2020-08-04 2023-07-13 캘시리틱스 테라퓨틱스, 인코포레이티드 트리페닐 칼실리틱 화합물의 제형
EP4698162A1 (en) * 2023-04-21 2026-02-25 Calcilytix Therapeutics, Inc. Treatment of hypoparathyroidism using triphenyl calcilytic compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0407097A (pt) * 2003-04-23 2006-01-24 Japan Tobacco Inc Antagonista do casr
KR20230106582A (ko) * 2020-08-04 2023-07-13 캘시리틱스 테라퓨틱스, 인코포레이티드 트리페닐 칼실리틱 화합물의 제형

Also Published As

Publication number Publication date
JP2023542932A (ja) 2023-10-12
TW202227046A (zh) 2022-07-16
WO2022060987A1 (en) 2022-03-24
IL301409A (en) 2023-05-01
EP4213829A1 (en) 2023-07-26
AU2021343475A9 (en) 2024-05-02
US20220087961A1 (en) 2022-03-24
CA3192684A1 (en) 2022-03-24
MX2023003129A (es) 2023-08-04
AU2021343475A1 (en) 2023-06-01

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Patent event date: 20230412

Patent event code: PA01051R01D

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Patent event code: PA02012R01D

Patent event date: 20240911

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