CA3186935A1 - Compounds and methods for modulating scn2a - Google Patents
Compounds and methods for modulating scn2aInfo
- Publication number
- CA3186935A1 CA3186935A1 CA3186935A CA3186935A CA3186935A1 CA 3186935 A1 CA3186935 A1 CA 3186935A1 CA 3186935 A CA3186935 A CA 3186935A CA 3186935 A CA3186935 A CA 3186935A CA 3186935 A1 CA3186935 A1 CA 3186935A1
- Authority
- CA
- Canada
- Prior art keywords
- modified
- modified oligonucleotide
- oligomeric compound
- nucleosides
- certain embodiments
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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- C12N2310/3341—5-Methylcytosine
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- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3525—MOE, methoxyethoxy
Landscapes
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| US20240002852A1 (en) * | 2020-10-01 | 2024-01-04 | Ionis Pharmaceuticals, Inc. | Compounds for modulating chmp7 |
| CA3219942A1 (en) * | 2021-05-10 | 2022-11-17 | Q-State Biosciences, Inc. | Compositions targeting sodium channel 1.6 |
| AU2023244348A1 (en) * | 2022-03-28 | 2024-10-10 | Praxis Precision Medicines, Inc. | Methods of using oligomeric compounds to treat scn2a-related disorders |
| AU2023348346A1 (en) * | 2022-09-30 | 2025-03-27 | Contera Pharma A/S | Antisense oligonucleotides for the treatment of canavan disease |
| WO2025059511A1 (en) * | 2023-09-15 | 2025-03-20 | Praxis Precision Medicines, Inc. | Elsunersen / prax-222 for use in the treatment of scn2a-related disorders |
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- 2021-08-06 CA CA3186935A patent/CA3186935A1/en active Pending
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| BR112023002034A2 (pt) | 2023-04-04 |
| US12227746B2 (en) | 2025-02-18 |
| CN116322707A (zh) | 2023-06-23 |
| CO2023002128A2 (es) | 2023-03-07 |
| EP4192476A4 (en) | 2024-09-18 |
| EP4192476A2 (en) | 2023-06-14 |
| MX2023001486A (es) | 2023-03-27 |
| AU2021320384A1 (en) | 2023-02-16 |
| WO2022032060A3 (en) | 2022-03-17 |
| TW202221123A (zh) | 2022-06-01 |
| US20250270556A1 (en) | 2025-08-28 |
| US20240026353A1 (en) | 2024-01-25 |
| CL2023000393A1 (es) | 2023-09-15 |
| CL2024000541A1 (es) | 2024-08-30 |
| ECSP23008455A (es) | 2023-05-31 |
| JP7834712B2 (ja) | 2026-03-24 |
| US20240102012A1 (en) | 2024-03-28 |
| CN116322707B (zh) | 2026-02-03 |
| WO2022032060A2 (en) | 2022-02-10 |
| KR20230048052A (ko) | 2023-04-10 |
| PE20231567A1 (es) | 2023-10-04 |
| JP2023536994A (ja) | 2023-08-30 |
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