CA3178834A1 - Large sequence pan-coronavirus vaccine compositions - Google Patents

Large sequence pan-coronavirus vaccine compositions

Info

Publication number
CA3178834A1
CA3178834A1 CA3178834A CA3178834A CA3178834A1 CA 3178834 A1 CA3178834 A1 CA 3178834A1 CA 3178834 A CA3178834 A CA 3178834A CA 3178834 A CA3178834 A CA 3178834A CA 3178834 A1 CA3178834 A1 CA 3178834A1
Authority
CA
Canada
Prior art keywords
composition
coronavirus
protein
conserved
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3178834A
Other languages
English (en)
French (fr)
Inventor
Lbachir Benmohamed
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California San Diego UCSD
Original Assignee
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California San Diego UCSD filed Critical University of California San Diego UCSD
Publication of CA3178834A1 publication Critical patent/CA3178834A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/165—Coronaviridae, e.g. avian infectious bronchitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA3178834A 2020-04-14 2021-04-14 Large sequence pan-coronavirus vaccine compositions Pending CA3178834A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063009907P 2020-04-14 2020-04-14
US63/009,907 2020-04-14
US202063084421P 2020-09-28 2020-09-28
US63/084,421 2020-09-28
PCT/US2021/027355 WO2021211760A1 (en) 2020-04-14 2021-04-14 Large sequence pan-coronavirus vaccine compositions

Publications (1)

Publication Number Publication Date
CA3178834A1 true CA3178834A1 (en) 2021-10-21

Family

ID=78084328

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3178834A Pending CA3178834A1 (en) 2020-04-14 2021-04-14 Large sequence pan-coronavirus vaccine compositions

Country Status (9)

Country Link
US (1) US20230226173A1 (enExample)
EP (3) EP4135765A4 (enExample)
JP (1) JP2023521837A (enExample)
KR (1) KR20230002571A (enExample)
CN (1) CN116033920A (enExample)
AU (1) AU2021254768A1 (enExample)
CA (1) CA3178834A1 (enExample)
IL (1) IL297335A (enExample)
WO (3) WO2021211749A1 (enExample)

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AU2022308712A1 (en) * 2021-07-09 2023-12-21 Atossa Therapeutics, Inc. Compositions and methods to increase coronavirus immune response
WO2023283642A2 (en) * 2021-07-09 2023-01-12 Modernatx, Inc. Pan-human coronavirus concatemeric vaccines
WO2023044542A1 (en) * 2021-09-24 2023-03-30 The University Of Adelaide Sars cov-2 vaccine
CN114395017B (zh) * 2021-10-29 2024-08-13 中国科学院深圳先进技术研究院 SARS-CoV-2病毒样颗粒的制备方法及其应用
EP4176898A1 (en) * 2021-11-08 2023-05-10 Charité - Universitätsmedizin Berlin Pan sars-cov2 vaccine antigen
US12186387B2 (en) 2021-11-29 2025-01-07 BioNTech SE Coronavirus vaccine
CN114181320B (zh) * 2021-12-09 2023-04-25 新疆医科大学第一附属医院 一种针对新冠原始株和变异株的重组多表位疫苗rSMEV及其应用
CN114478716B (zh) * 2021-12-28 2024-05-28 梅州市人民医院(梅州市医学科学院) 一种多肽组合及其在新型冠状病毒抗体检测中的应用
WO2023159082A2 (en) * 2022-02-15 2023-08-24 Ohio State Innovation Foundation Nanotechnology based intranasal vaccine for covid-19 comprising chitosan
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WO2024011163A1 (en) * 2022-07-06 2024-01-11 Georgia State University Research Foundation, Inc. Coronavirus vaccines and methods of use thereof
WO2024064965A2 (en) * 2022-09-23 2024-03-28 Advanced Rna Vaccine (Arv) Technologies, Inc. Nucleic acid-based universal vaccine and methods of use thereof
AU2023357320A1 (en) * 2022-10-06 2025-04-17 BioNTech SE Rna compositions targeting claudin-18.2
CN116041540B (zh) * 2022-11-18 2025-10-17 中山大学 一种增强新冠突变株疫苗广谱性的方法及新冠广谱疫苗
WO2024191944A2 (en) * 2023-03-10 2024-09-19 The Regents Of The University Of California Broad-spectrum multi-antigen pan-coronavirus vaccine
WO2024206843A2 (en) * 2023-03-31 2024-10-03 University Of Kansas Compositions including modified coronavirus vaccines and uses thereof
EP4711466A1 (en) * 2023-04-28 2026-03-18 Xianwei (Hainan) Biotechnology Co. Ltd. Engineered mrna and use thereof
CN117903264B (zh) * 2023-10-26 2026-04-03 中国人民解放军海军军医大学 新冠病毒SARS-CoV-2 HLA-A2限制性表位肽及应用
CN117330750A (zh) * 2023-12-01 2024-01-02 北京生物制品研究所有限责任公司 一种筛选新冠病毒早期毒种的方法和制造疫苗的方法

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Also Published As

Publication number Publication date
EP4135764A4 (en) 2024-05-08
EP4135765A4 (en) 2024-05-08
JP2023521837A (ja) 2023-05-25
EP4135762A4 (en) 2024-05-15
EP4135765A1 (en) 2023-02-22
WO2021211749A1 (en) 2021-10-21
AU2021254768A1 (en) 2022-11-17
EP4135764A1 (en) 2023-02-22
WO2021211760A1 (en) 2021-10-21
CN116033920A (zh) 2023-04-28
EP4135762A1 (en) 2023-02-22
US20230226173A1 (en) 2023-07-20
WO2021211748A1 (en) 2021-10-21
KR20230002571A (ko) 2023-01-05
IL297335A (en) 2022-12-01

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