CA3177169A1 - Antibodies against sars-cov-2 - Google Patents
Antibodies against sars-cov-2 Download PDFInfo
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- CA3177169A1 CA3177169A1 CA3177169A CA3177169A CA3177169A1 CA 3177169 A1 CA3177169 A1 CA 3177169A1 CA 3177169 A CA3177169 A CA 3177169A CA 3177169 A CA3177169 A CA 3177169A CA 3177169 A1 CA3177169 A1 CA 3177169A1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1002—Coronaviridae
- C07K16/1003—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2 or Covid-19]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (29)
| Application Number | Priority Date | Filing Date | Title |
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| US202063022392P | 2020-05-08 | 2020-05-08 | |
| US63/022,392 | 2020-05-08 | ||
| US202063024372P | 2020-05-13 | 2020-05-13 | |
| US63/024,372 | 2020-05-13 | ||
| US202063027814P | 2020-05-20 | 2020-05-20 | |
| US63/027,814 | 2020-05-20 | ||
| US202063029338P | 2020-05-22 | 2020-05-22 | |
| US63/029,338 | 2020-05-22 | ||
| US202063031286P | 2020-05-28 | 2020-05-28 | |
| US63/031,286 | 2020-05-28 | ||
| US202063033045P | 2020-06-01 | 2020-06-01 | |
| US63/033,045 | 2020-06-01 | ||
| US202063036683P | 2020-06-09 | 2020-06-09 | |
| US63/036,683 | 2020-06-09 | ||
| US202063039939P | 2020-06-16 | 2020-06-16 | |
| US63/039,939 | 2020-06-16 | ||
| US202063046465P | 2020-06-30 | 2020-06-30 | |
| US63/046,465 | 2020-06-30 | ||
| US202063057767P | 2020-07-28 | 2020-07-28 | |
| US63/057,767 | 2020-07-28 | ||
| US202063090667P | 2020-10-12 | 2020-10-12 | |
| US63/090,667 | 2020-10-12 | ||
| US202063113450P | 2020-11-13 | 2020-11-13 | |
| US63/113,450 | 2020-11-13 | ||
| US202163153784P | 2021-02-25 | 2021-02-25 | |
| US63/153,784 | 2021-02-25 | ||
| US202163170368P | 2021-04-02 | 2021-04-02 | |
| US63/170,368 | 2021-04-02 | ||
| PCT/US2021/031442 WO2021226560A1 (en) | 2020-05-08 | 2021-05-07 | Antibodies against sars-cov-2 |
Publications (1)
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| CA3177169A1 true CA3177169A1 (en) | 2021-11-11 |
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Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP4146690A1 (ko) |
| JP (1) | JP2023525039A (ko) |
| KR (1) | KR20230010676A (ko) |
| AU (1) | AU2021268361A1 (ko) |
| BR (1) | BR112022022523A2 (ko) |
| CA (1) | CA3177169A1 (ko) |
| CL (1) | CL2022003085A1 (ko) |
| CO (1) | CO2022017670A2 (ko) |
| IL (1) | IL297988A (ko) |
| MX (1) | MX2022013886A (ko) |
| WO (1) | WO2021226560A1 (ko) |
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| DK3872091T3 (da) * | 2020-02-26 | 2023-09-11 | Vir Biotechnology Inc | Antistoffer mod sars-cov-2 |
| MX2021004130A (es) | 2020-04-02 | 2021-06-15 | Regeneron Pharma | Anticuerpos contra glicoproteína de espícula anti-sars-cov-2 y fragmentos de unión al antígeno. |
| CR20220660A (es) | 2020-06-03 | 2023-02-17 | Regeneron Pharma | Métodos para tratar o prevenir infecciones por sars-cov2 y covid-19 con anticuerpos de glicoproteína espícular anti-sars-cov-2 |
| AU2021306709A1 (en) | 2020-07-06 | 2023-02-09 | Flagship Pioneering Innovations Vi, Llc | Antigen binding molecules targeting SARS-CoV-2 |
| IL300720A (en) | 2020-08-26 | 2023-04-01 | Flagship Pioneering Innovations Vi Llc | Antigen binding molecules targeting Sars-cov-2 |
| WO2022263638A1 (en) * | 2021-06-17 | 2022-12-22 | Centre Hospitalier Universitaire Vaudois (C.H.U.V.) | Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection |
| IL310012A (en) * | 2021-07-14 | 2024-03-01 | Regeneron Pharma | Antibodies against SARS-COV-2 spike glycoprotein and antigen-binding fragments |
| WO2023201256A1 (en) * | 2022-04-12 | 2023-10-19 | Vir Biotechnology, Inc. | High dose antibody therapies for sars-cov-2 infection |
| WO2023215910A1 (en) | 2022-05-06 | 2023-11-09 | Generate Biomedicines, Inc. | Antigen binding molecules targeting sars-cov-2 |
| US20230365658A1 (en) * | 2022-05-16 | 2023-11-16 | Lawrence Livermore National Security, Llc | REPAIRED THERAPEUTIC AND PROPHYLACTIC ANTIBODIES AGAINST SARS-CoV-2 VARIANTS |
| WO2023235827A2 (en) * | 2022-06-03 | 2023-12-07 | The Rockefeller University | Coronavirus-inhibiting antibodies |
| WO2024006472A1 (en) | 2022-06-30 | 2024-01-04 | Vir Biotechnology, Inc. | Antibodies that bind to multiple sarbecoviruses |
| WO2024081269A1 (en) * | 2022-10-10 | 2024-04-18 | Dixit Rohan | Therapeutic combinations and methods to treat long covid |
| WO2024102674A1 (en) | 2022-11-13 | 2024-05-16 | Generate Biomedicines, Inc. | Antigen binding molecules targeting sars-cov-2 |
| CN117362421A (zh) * | 2022-12-02 | 2024-01-09 | 中国科学院微生物研究所 | 一种针对新冠病毒rbd的广谱单克隆抗体、其制备方法及应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4751180A (en) | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
| US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5959177A (en) | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
| US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| CA2116774C (en) | 1991-09-19 | 2003-11-11 | Paul J. Carter | Expression in e. coli antibody fragments having at least a cysteine present as a free thiol. use for the production of bifunctional f(ab') 2 antibodies |
| US5789199A (en) | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
| US5840523A (en) | 1995-03-01 | 1998-11-24 | Genetech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| US6040498A (en) | 1998-08-11 | 2000-03-21 | North Caroline State University | Genetically engineered duckweed |
| US6833268B1 (en) | 1999-06-10 | 2004-12-21 | Abgenix, Inc. | Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions |
| DE60022369T2 (de) | 1999-10-04 | 2006-05-18 | Medicago Inc., Sainte Foy | Verfahren zur regulation der transkription von fremden genen in gegenwart von stickstoff |
| US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| AU2004215125B2 (en) | 2003-02-26 | 2011-01-06 | Institute For Research In Biomedicine | Monoclonal antibody production by EBV transformation of B cells |
| US7498415B2 (en) | 2003-09-24 | 2009-03-03 | Kyowa Hakko Kogyo Co., Ltd. | Recombinant antibody against human insulin-like growth factor |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| US8119772B2 (en) | 2006-09-29 | 2012-02-21 | California Institute Of Technology | MART-1 T cell receptors |
| CN106459182B (zh) | 2013-12-30 | 2021-09-03 | 岸迈生物科技有限公司 | 串联fab免疫球蛋白及其用途 |
| JP6587696B2 (ja) | 2015-05-13 | 2019-10-09 | ズムトール バイオロジクス、インコーポレイテッド | アフコシル化タンパク質、前記タンパク質を発現する細胞、及び関連する方法 |
| WO2019024979A1 (en) | 2017-07-31 | 2019-02-07 | Institute For Research In Biomedicine | FUNCTIONAL DOMAIN ANTIBODIES IN THE ELBOW REGION |
| MX2020003145A (es) | 2017-09-22 | 2020-07-29 | Wuxi Biologics Ireland Ltd | Nuevos complejos de polipeptidos biespecificos. |
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- 2021-05-07 KR KR1020227043022A patent/KR20230010676A/ko unknown
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| KR20230010676A (ko) | 2023-01-19 |
| CO2022017670A2 (es) | 2023-03-07 |
| AU2021268361A1 (en) | 2022-12-08 |
| MX2022013886A (es) | 2022-11-30 |
| IL297988A (en) | 2023-01-01 |
| JP2023525039A (ja) | 2023-06-14 |
| CL2022003085A1 (es) | 2023-09-01 |
| EP4146690A1 (en) | 2023-03-15 |
| WO2021226560A1 (en) | 2021-11-11 |
| BR112022022523A2 (pt) | 2023-01-10 |
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