CA3174786A1 - Activatable cytokine constructs and related compositions and methods - Google Patents

Activatable cytokine constructs and related compositions and methods Download PDF

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Publication number
CA3174786A1
CA3174786A1 CA3174786A CA3174786A CA3174786A1 CA 3174786 A1 CA3174786 A1 CA 3174786A1 CA 3174786 A CA3174786 A CA 3174786A CA 3174786 A CA3174786 A CA 3174786A CA 3174786 A1 CA3174786 A1 CA 3174786A1
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CA
Canada
Prior art keywords
seq
acc
amino acids
interferon
combination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3174786A
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English (en)
French (fr)
Inventor
Sayantan Mitra
Nicole G. LAPUYADE
Hikmat Haizar ASSI
Madan M. Paidhungat
Dylan L. Daniel
Erwan LE SCOLAN
Walter A. BOGDANOFF
Na CAI
Hsin Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytomx Therapeutics Inc
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Cytomx Therapeutics Inc
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Filing date
Publication date
Application filed by Cytomx Therapeutics Inc filed Critical Cytomx Therapeutics Inc
Publication of CA3174786A1 publication Critical patent/CA3174786A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA3174786A 2020-04-10 2021-04-09 Activatable cytokine constructs and related compositions and methods Pending CA3174786A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202063008542P 2020-04-10 2020-04-10
US63/008,542 2020-04-10
US202163161889P 2021-03-16 2021-03-16
US63/161,889 2021-03-16
US202163164849P 2021-03-23 2021-03-23
US63/164,849 2021-03-23
PCT/US2021/026675 WO2021207669A1 (en) 2020-04-10 2021-04-09 Activatable cytokine constructs and related compositions and methods

Publications (1)

Publication Number Publication Date
CA3174786A1 true CA3174786A1 (en) 2021-10-14

Family

ID=75747127

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3174786A Pending CA3174786A1 (en) 2020-04-10 2021-04-09 Activatable cytokine constructs and related compositions and methods

Country Status (11)

Country Link
US (3) US11365233B2 (https=)
EP (1) EP4133085A1 (https=)
JP (1) JP2023520922A (https=)
KR (1) KR20220167295A (https=)
CN (1) CN115667523B (https=)
AU (2) AU2021254283B2 (https=)
BR (1) BR112022020440A2 (https=)
CA (1) CA3174786A1 (https=)
IL (1) IL297225A (https=)
MX (1) MX2022012592A (https=)
WO (1) WO2021207669A1 (https=)

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CN120936384A (zh) 2023-04-12 2025-11-11 西托姆克斯治疗公司 掩蔽多肽、可活化细胞因子构建体以及相关组合物和方法
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Publication number Publication date
US20250179141A1 (en) 2025-06-05
US11365233B2 (en) 2022-06-21
KR20220167295A (ko) 2022-12-20
MX2022012592A (es) 2022-12-07
CN115667523B (zh) 2026-03-31
CN115667523A (zh) 2023-01-31
AU2021254283A1 (en) 2022-11-10
BR112022020440A2 (pt) 2022-12-27
IL297225A (en) 2022-12-01
US20220402990A1 (en) 2022-12-22
AU2021254283B2 (en) 2025-12-11
JP2023520922A (ja) 2023-05-22
US12091442B2 (en) 2024-09-17
WO2021207669A1 (en) 2021-10-14
US20210317177A1 (en) 2021-10-14
AU2026200173A1 (en) 2026-02-05
EP4133085A1 (en) 2023-02-15

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