CA3171330A1 - Methods for treating tauopathy - Google Patents
Methods for treating tauopathyInfo
- Publication number
- CA3171330A1 CA3171330A1 CA3171330A CA3171330A CA3171330A1 CA 3171330 A1 CA3171330 A1 CA 3171330A1 CA 3171330 A CA3171330 A CA 3171330A CA 3171330 A CA3171330 A CA 3171330A CA 3171330 A1 CA3171330 A1 CA 3171330A1
- Authority
- CA
- Canada
- Prior art keywords
- deuterated
- optionally substituted
- ester
- acid
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062976958P | 2020-02-14 | 2020-02-14 | |
| US62/976,958 | 2020-02-14 | ||
| PCT/US2021/017981 WO2021163580A1 (en) | 2020-02-14 | 2021-02-12 | Methods for treating tauopathy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3171330A1 true CA3171330A1 (en) | 2021-08-19 |
Family
ID=77273602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3171330A Pending CA3171330A1 (en) | 2020-02-14 | 2021-02-12 | Methods for treating tauopathy |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20210251933A1 (enExample) |
| EP (1) | EP4103169A4 (enExample) |
| JP (2) | JP2023513901A (enExample) |
| KR (1) | KR20220140808A (enExample) |
| CN (1) | CN116507325A (enExample) |
| AU (1) | AU2021220981A1 (enExample) |
| CA (1) | CA3171330A1 (enExample) |
| IL (1) | IL295512A (enExample) |
| WO (1) | WO2021163580A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20240064584A (ko) * | 2021-02-05 | 2024-05-13 | 레트로토프 인코포레이티드 | 중수소화 아라키돈산을 사용한 신경퇴행성 질환의 치료에 대한 환자의 반응을 평가하는 방법 |
| US11510889B2 (en) | 2021-02-05 | 2022-11-29 | Retrotope, Inc. | Methods for inhibiting the progression of neurodegenerative diseases |
| US12109194B2 (en) | 2021-02-05 | 2024-10-08 | Biojiva Llc | Synergistic combination therapy for treating ALS |
| US11491130B2 (en) | 2021-02-05 | 2022-11-08 | Retrotope, Inc. | Methods of treating amyotrophic lateral sclerosis |
| US20230165824A1 (en) * | 2021-09-03 | 2023-06-01 | Biojiva Llc | METHODS, SYSTEMS AND COMPOSITIONS FOR INHIBITION OF CELLULAR DYSFUNCTION AND CELL DEATH WITH DEUTERATED PUFAs |
| CN118201607A (zh) * | 2021-09-03 | 2024-06-14 | 拜奥吉瓦有限责任公司 | 利用氘代pufa抑制细胞功能障碍和细胞死亡的方法、系统和组合物 |
| CA3243042A1 (en) * | 2021-12-21 | 2025-04-08 | Biojiva Llc | METHODS AND COMPOSITIONS INTENDED FOR THE TREATMENT OF INFLAMMATORY DISEASE |
| WO2023192406A2 (en) * | 2022-03-30 | 2023-10-05 | Retrotope, Inc. | Prophylactic methods for treating als |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2493296T3 (en) | 2009-10-30 | 2019-04-15 | Retrotope Inc | REMOVAL OF OXIDATIVE STRESS STATES WITH PUFA DERIVATIVES |
| US10058522B2 (en) * | 2011-04-26 | 2018-08-28 | Retrotope, Inc. | Oxidative retinal diseases |
| US10154983B2 (en) * | 2011-04-26 | 2018-12-18 | Retrotope, Inc. | Neurodegenerative disorders and muscle diseases implicating PUFAs |
| WO2018094116A1 (en) * | 2016-11-17 | 2018-05-24 | Retrotope, Inc. | Isotopically modified components and therapeutic uses thereof |
| EP3461479B1 (en) * | 2017-09-27 | 2021-06-16 | Julie Blivet | Nutraceutical and pharmaceutical compositions, and uses thereof for preserving cognitive functions |
| EP3806841A1 (en) * | 2018-06-15 | 2021-04-21 | Flagship Pioneering Innovations V, Inc. | Decreasing immune activity through modulation of postcellular signaling factors |
-
2021
- 2021-02-12 KR KR1020227031617A patent/KR20220140808A/ko active Pending
- 2021-02-12 CA CA3171330A patent/CA3171330A1/en active Pending
- 2021-02-12 US US17/175,397 patent/US20210251933A1/en not_active Abandoned
- 2021-02-12 JP JP2022548978A patent/JP2023513901A/ja active Pending
- 2021-02-12 EP EP21753302.5A patent/EP4103169A4/en active Pending
- 2021-02-12 AU AU2021220981A patent/AU2021220981A1/en active Pending
- 2021-02-12 WO PCT/US2021/017981 patent/WO2021163580A1/en not_active Ceased
- 2021-02-12 IL IL295512A patent/IL295512A/en unknown
- 2021-02-12 CN CN202180028457.1A patent/CN116507325A/zh active Pending
-
2024
- 2024-07-09 US US18/767,538 patent/US20250177339A1/en active Pending
-
2025
- 2025-11-25 JP JP2025202414A patent/JP2026035680A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20210251933A1 (en) | 2021-08-19 |
| JP2026035680A (ja) | 2026-03-04 |
| US20250177339A1 (en) | 2025-06-05 |
| JP2023513901A (ja) | 2023-04-04 |
| CN116507325A (zh) | 2023-07-28 |
| AU2021220981A1 (en) | 2022-09-22 |
| WO2021163580A1 (en) | 2021-08-19 |
| EP4103169A4 (en) | 2024-03-13 |
| IL295512A (en) | 2022-10-01 |
| KR20220140808A (ko) | 2022-10-18 |
| EP4103169A1 (en) | 2022-12-21 |
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