CA3169057A1 - Kv3 modulators - Google Patents

Kv3 modulators

Info

Publication number
CA3169057A1
CA3169057A1 CA3169057A CA3169057A CA3169057A1 CA 3169057 A1 CA3169057 A1 CA 3169057A1 CA 3169057 A CA3169057 A CA 3169057A CA 3169057 A CA3169057 A CA 3169057A CA 3169057 A1 CA3169057 A1 CA 3169057A1
Authority
CA
Canada
Prior art keywords
benzofuran
dione
disorders
compound
cyclopropane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3169057A
Other languages
English (en)
French (fr)
Inventor
Giuseppe Alvaro
Agostino Marasco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Autifony Therapeutics Ltd
Original Assignee
Autifony Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Autifony Therapeutics Ltd filed Critical Autifony Therapeutics Ltd
Publication of CA3169057A1 publication Critical patent/CA3169057A1/en
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Gyroscopes (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Amplifiers (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA3169057A 2020-02-06 2020-02-06 Kv3 modulators Pending CA3169057A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/GB2020/050268 WO2021156584A1 (en) 2020-02-06 2020-02-06 Kv3 modulators

Publications (1)

Publication Number Publication Date
CA3169057A1 true CA3169057A1 (en) 2021-08-12

Family

ID=69591671

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3169057A Pending CA3169057A1 (en) 2020-02-06 2020-02-06 Kv3 modulators

Country Status (11)

Country Link
EP (1) EP4100402A1 (ko)
JP (1) JP2023523501A (ko)
KR (1) KR20220139923A (ko)
CN (1) CN115066424A (ko)
AU (1) AU2020427632A1 (ko)
BR (1) BR112022013339A2 (ko)
CA (1) CA3169057A1 (ko)
CL (1) CL2022002081A1 (ko)
IL (1) IL295027A (ko)
MX (1) MX2022009702A (ko)
WO (1) WO2021156584A1 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024121552A1 (en) 2022-12-06 2024-06-13 Autifony Therapeutics Limited Compounds for the treatment of centra nervous system disorders
CN117448440A (zh) * 2023-10-23 2024-01-26 中国人民解放军空军军医大学 Kv3在制备诊断或治疗创伤后应激障碍异常恐惧记忆消退产品中的应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102753533B (zh) 2009-12-11 2014-07-30 奥蒂福尼疗法有限公司 咪唑烷二酮衍生物
AU2011340258C1 (en) * 2010-12-06 2016-10-20 Autifony Therapeutics Limited Hydantoin derivatives useful as Kv3 inhibitors
GB201209986D0 (en) 2012-06-06 2012-07-18 Autifony Therapeutics Ltd Novel compounds
CN103596943B (zh) 2011-06-07 2016-10-12 奥蒂福尼疗法有限公司 用作kv3抑制剂的乙内酰脲衍生物
DK2788339T3 (en) 2011-12-06 2016-05-23 Autifony Therapeutics Ltd HYDANTOIN DERIVATIVES, USEFUL AS QU3 INHIBITORS
US9669030B2 (en) 2012-05-22 2017-06-06 Autifony Therapeutics Limited Hydantoin derivatives as Kv3 inhibitors
EP2852589B1 (en) 2012-05-22 2021-04-28 Autifony Therapeutics Limited Triazoles as kv3 inhibitors
WO2013182851A1 (en) 2012-06-06 2013-12-12 Autifony Therapeutics Limited Prophylaxis or treatment of diseases where a modulator of kv3.3 channels is required
GB201521751D0 (en) 2015-12-10 2016-01-27 Autifony Therapeutics Ltd Novel uses
GB201522179D0 (en) 2015-12-16 2016-01-27 Autifony Therapeutics Ltd Novel compounds
GB201613163D0 (en) 2016-07-29 2016-09-14 Autifony Therapeutics Ltd Novel compounds
US20200039970A1 (en) 2016-12-16 2020-02-06 Autifony Therapeutics Limited Hydantoin modulators of kv3 channels
JP2022502370A (ja) 2018-09-21 2022-01-11 バイオノミクス リミテッド 置換ピリジニル化合物およびその使用
IL282096B1 (en) * 2018-10-16 2024-03-01 Autifony Therapeutics Ltd History of 3-[5-[(3,3-dialkyl-2H-benzofuran-4-yl]oxy]pyrazin-2-yl]-5,5-dialkyl-imidazolidine-2,4-dione and pharmaceutical preparations containing them
JP2022528631A (ja) 2019-03-25 2022-06-15 バイオノミクス リミテッド 置換n-ヘテロアリール化合物及びその使用

Also Published As

Publication number Publication date
IL295027A (en) 2022-09-01
CN115066424A (zh) 2022-09-16
CL2022002081A1 (es) 2023-05-26
MX2022009702A (es) 2022-09-07
JP2023523501A (ja) 2023-06-06
AU2020427632A1 (en) 2022-08-18
EP4100402A1 (en) 2022-12-14
WO2021156584A1 (en) 2021-08-12
BR112022013339A2 (pt) 2022-09-13
KR20220139923A (ko) 2022-10-17

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Legal Events

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Effective date: 20220920

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