CA3166816A1 - Il-7r.alpha..gamma.c binding compounds - Google Patents
Il-7r.alpha..gamma.c binding compounds Download PDFInfo
- Publication number
- CA3166816A1 CA3166816A1 CA3166816A CA3166816A CA3166816A1 CA 3166816 A1 CA3166816 A1 CA 3166816A1 CA 3166816 A CA3166816 A CA 3166816A CA 3166816 A CA3166816 A CA 3166816A CA 3166816 A1 CA3166816 A1 CA 3166816A1
- Authority
- CA
- Canada
- Prior art keywords
- seqidno
- ligand
- 7rayc
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5418—IL-7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062969432P | 2020-02-03 | 2020-02-03 | |
| US62/969,432 | 2020-02-03 | ||
| US202063041158P | 2020-06-19 | 2020-06-19 | |
| US63/041,158 | 2020-06-19 | ||
| PCT/US2021/016361 WO2021158623A1 (en) | 2020-02-03 | 2021-02-03 | IL-7Rαγc BINDING COMPOUNDS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3166816A1 true CA3166816A1 (en) | 2021-08-12 |
Family
ID=77200524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3166816A Pending CA3166816A1 (en) | 2020-02-03 | 2021-02-03 | Il-7r.alpha..gamma.c binding compounds |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11746139B2 (https=) |
| EP (1) | EP4100427A4 (https=) |
| JP (1) | JP2023514128A (https=) |
| KR (1) | KR20220139918A (https=) |
| CN (1) | CN115315435A (https=) |
| AU (2) | AU2021217353A1 (https=) |
| BR (1) | BR112022015002A2 (https=) |
| CA (1) | CA3166816A1 (https=) |
| IL (1) | IL295304A (https=) |
| MX (1) | MX2022009390A (https=) |
| TW (2) | TW202342505A (https=) |
| WO (1) | WO2021158623A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2021001493A (es) | 2018-08-06 | 2021-07-15 | Medikine Inc | Compuestos de fijación al receptor de il-2. |
| KR20220110207A (ko) | 2019-11-05 | 2022-08-05 | 메디카인 인코포레이티드 | IL-2RβγC 결합 화합물 |
| MX2022005404A (es) | 2019-11-05 | 2022-09-09 | Medikine Inc | Compuestos de fijación a il-2r e il-7r dual. |
| JP2023512687A (ja) * | 2020-02-03 | 2023-03-28 | メディカイン、インコーポレイテッド | ＩＬ－７Ｒα結合化合物 |
| IL295304A (en) | 2020-02-03 | 2022-10-01 | Medikine Inc | Il-7 receptor alpha gamma c binding compounds, compositions comprising same and uses thereof |
| KR20230097168A (ko) * | 2020-11-04 | 2023-06-30 | 메디카인 인코포레이티드 | IL-2Rβγc 결합 화합물 및 이의 용도 |
| WO2023133595A2 (en) | 2022-01-10 | 2023-07-13 | Sana Biotechnology, Inc. | Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses |
| US20250222027A1 (en) | 2022-04-01 | 2025-07-10 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
| US11999771B2 (en) * | 2022-04-07 | 2024-06-04 | Medikine, Inc. | IL-7Rαγc ligand immunoglobulin fusion proteins |
| WO2024054870A1 (en) | 2022-09-06 | 2024-03-14 | Medikine, Inc. | Use of il-7r-alpha-gamma agonist peptides in cell manufacturing |
| US20240101959A1 (en) | 2022-09-06 | 2024-03-28 | Medikine, Inc. | Use of il-2r-beta-gamma agonist peptides in cell manufacturing |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5635597A (en) | 1994-05-27 | 1997-06-03 | Affymax Technologies, N.V. | Peptides that bind IL-2 receptors |
| PT1454138E (pt) | 2001-12-04 | 2012-03-28 | Merck Patent Gmbh | Imunocitoquinas com seletividade modulada |
| US20050054054A1 (en) * | 2002-11-12 | 2005-03-10 | Foss Francine M. | Interleukin-7 molecules with altered biological properties |
| CA2551915C (en) | 2003-12-30 | 2015-06-23 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Il-7 fusion proteins |
| CN101072793B (zh) | 2004-12-09 | 2012-06-20 | 默克专利有限公司 | 具有降低的免疫原性的il-7变体 |
| EP1828231A2 (en) | 2004-12-22 | 2007-09-05 | Novartis Vaccines and Diagnostics, Inc. | Group b streptococcus |
| WO2010099084A2 (en) | 2009-02-27 | 2010-09-02 | Monsanto Technology Llc | Isolated novel nucleic acid and protein molecules from corn and methods of using those molecules |
| ES2866674T3 (es) | 2010-11-12 | 2021-10-19 | Nektar Therapeutics | Conjugados de una fracción de IL-2 y un polímero |
| US9266937B2 (en) * | 2010-12-10 | 2016-02-23 | University Of Central Florida Research Foundation, Inc. | Compositions comprising IL-7 receptor ligands |
| HRP20200470T1 (hr) | 2011-01-18 | 2020-10-02 | Bioniz, Llc | Pripravci za modulaciju aktivnosti gama-c-citokina |
| WO2015164815A1 (en) | 2014-04-24 | 2015-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
| GB2538666A (en) | 2014-07-21 | 2016-11-23 | Delinia Inc | Molecules that selectively activate regulatory T cells for the treatment of autoimmune diseases |
| WO2016025385A1 (en) | 2014-08-11 | 2016-02-18 | Delinia, Inc. | Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| PT3328894T (pt) | 2015-08-06 | 2019-02-13 | Agency Science Tech & Res | Anticorpos de cadeia comum gama/il2rbeta |
| SG11201803330WA (en) | 2015-10-22 | 2018-05-30 | Juno Therapeutics Gmbh | Methods for culturing cells and kits and apparatus for same |
| US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| CA3011374A1 (en) | 2016-02-05 | 2017-08-10 | Washington University | Compositions and methods for targeted cytokine delivery |
| US11077172B2 (en) | 2016-11-08 | 2021-08-03 | Delinia, Inc. | IL-2 variants for the treatment of psoriasis |
| DK3551664T3 (da) | 2016-12-09 | 2021-05-03 | Ose Immunotherapeutics | Antistoffer og polypeptider rettet mod cd127 |
| BR122020025384B1 (pt) | 2016-12-13 | 2022-07-12 | Delinia, Inc | Proteínas de fusão e dimérica, usos das mesmas e composição farmacêutica |
| MX2021001493A (es) | 2018-08-06 | 2021-07-15 | Medikine Inc | Compuestos de fijación al receptor de il-2. |
| WO2020247388A2 (en) | 2019-06-03 | 2020-12-10 | Medikine, Inc. | Il-2alpha receptor subunit binding compounds |
| US20220119492A1 (en) | 2019-11-05 | 2022-04-21 | Medikine, Inc. | Il-2r-beta-gamma binding compounds and uses thereof |
| KR20220110207A (ko) | 2019-11-05 | 2022-08-05 | 메디카인 인코포레이티드 | IL-2RβγC 결합 화합물 |
| MX2022005404A (es) | 2019-11-05 | 2022-09-09 | Medikine Inc | Compuestos de fijación a il-2r e il-7r dual. |
| AU2020406083A1 (en) | 2019-12-17 | 2022-06-16 | Boehringer Ingelheim International Gmbh | Bifunctional molecules comprising an IL-7 variant |
| JP2023512687A (ja) | 2020-02-03 | 2023-03-28 | メディカイン、インコーポレイテッド | ＩＬ－７Ｒα結合化合物 |
| IL295304A (en) | 2020-02-03 | 2022-10-01 | Medikine Inc | Il-7 receptor alpha gamma c binding compounds, compositions comprising same and uses thereof |
| KR20230097168A (ko) | 2020-11-04 | 2023-06-30 | 메디카인 인코포레이티드 | IL-2Rβγc 결합 화합물 및 이의 용도 |
| US11999771B2 (en) | 2022-04-07 | 2024-06-04 | Medikine, Inc. | IL-7Rαγc ligand immunoglobulin fusion proteins |
-
2021
- 2021-02-03 IL IL295304A patent/IL295304A/en unknown
- 2021-02-03 CN CN202180022881.5A patent/CN115315435A/zh not_active Withdrawn
- 2021-02-03 KR KR1020227030327A patent/KR20220139918A/ko not_active Withdrawn
- 2021-02-03 TW TW112126553A patent/TW202342505A/zh unknown
- 2021-02-03 MX MX2022009390A patent/MX2022009390A/es unknown
- 2021-02-03 EP EP21750982.7A patent/EP4100427A4/en not_active Withdrawn
- 2021-02-03 US US17/166,462 patent/US11746139B2/en active Active
- 2021-02-03 JP JP2022547164A patent/JP2023514128A/ja active Pending
- 2021-02-03 CA CA3166816A patent/CA3166816A1/en active Pending
- 2021-02-03 BR BR112022015002A patent/BR112022015002A2/pt not_active IP Right Cessation
- 2021-02-03 TW TW110104084A patent/TWI812918B/zh active
- 2021-02-03 WO PCT/US2021/016361 patent/WO2021158623A1/en not_active Ceased
- 2021-02-03 AU AU2021217353A patent/AU2021217353A1/en not_active Abandoned
-
2023
- 2023-07-11 US US18/350,543 patent/US11965015B2/en active Active
-
2024
- 2024-03-21 AU AU2024201860A patent/AU2024201860A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US11965015B2 (en) | 2024-04-23 |
| WO2021158623A1 (en) | 2021-08-12 |
| MX2022009390A (es) | 2022-11-16 |
| EP4100427A1 (en) | 2022-12-14 |
| US20210253670A1 (en) | 2021-08-19 |
| AU2021217353A1 (en) | 2022-08-25 |
| CN115315435A (zh) | 2022-11-08 |
| US11746139B2 (en) | 2023-09-05 |
| KR20220139918A (ko) | 2022-10-17 |
| AU2024201860A1 (en) | 2024-05-16 |
| EP4100427A4 (en) | 2024-01-17 |
| US20230357358A1 (en) | 2023-11-09 |
| JP2023514128A (ja) | 2023-04-05 |
| IL295304A (en) | 2022-10-01 |
| TWI812918B (zh) | 2023-08-21 |
| TW202144390A (zh) | 2021-12-01 |
| BR112022015002A2 (pt) | 2022-12-06 |
| TW202342505A (zh) | 2023-11-01 |
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| US11248030B2 (en) | Dual IL-2R and IL-7R binding compounds | |
| US20230331801A1 (en) | Il-2r-beta-gamma binding compounds | |
| EP4268901A2 (en) | Il-2r beta-gamma c binding compounds and uses thereof | |
| US20220119492A1 (en) | Il-2r-beta-gamma binding compounds and uses thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20220802 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20250826 |
|
| U13 | Renewal or maintenance fee not paid |
Free format text: ST27 STATUS EVENT CODE: N-2-6-U10-U13-U300 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: DEEMED ABANDONED - FAILURE TO RESPOND TO MAINTENANCE FEE NOTICE Effective date: 20251027 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: N-6-6-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20260102 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: N-6-6-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20260317 |