CA3162639A1 - Modele murin de thrombocytopenie allo-immune fƒtale/neonatale - Google Patents

Modele murin de thrombocytopenie allo-immune fƒtale/neonatale

Info

Publication number
CA3162639A1
CA3162639A1 CA3162639A CA3162639A CA3162639A1 CA 3162639 A1 CA3162639 A1 CA 3162639A1 CA 3162639 A CA3162639 A CA 3162639A CA 3162639 A CA3162639 A CA 3162639A CA 3162639 A1 CA3162639 A1 CA 3162639A1
Authority
CA
Canada
Prior art keywords
gpiiia
mouse
hpa
antibody
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3162639A
Other languages
English (en)
Inventor
Peter J. Newman
Huiying Zhi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Versiti Blood Research Institute Foundation Inc
Original Assignee
Zhi Huiying
Versiti Blood Research Institute Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhi Huiying, Versiti Blood Research Institute Foundation Inc filed Critical Zhi Huiying
Publication of CA3162639A1 publication Critical patent/CA3162639A1/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Humanized animals, e.g. knockin
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0325—Animal model for autoimmune diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0387—Animal model for diseases of the immune system

Abstract

L'invention concerne une souris transgénique comprenant des mutations T30A, S32P, Q33L, N39D et M470Q dans GPIIIa, ainsi que des procédés de fabrication de la souris transgénique et des procédés d'utilisation de la souris transgénique pour cribler des composés de test.
CA3162639A 2019-11-05 2019-11-05 Modele murin de thrombocytopenie allo-immune fƒtale/neonatale Pending CA3162639A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2019/059869 WO2021091539A1 (fr) 2019-11-05 2019-11-05 Modèle murin de thrombocytopénie allo-immune fœtale/néonatale

Publications (1)

Publication Number Publication Date
CA3162639A1 true CA3162639A1 (fr) 2021-05-14

Family

ID=69159981

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3162639A Pending CA3162639A1 (fr) 2019-11-05 2019-11-05 Modele murin de thrombocytopenie allo-immune fƒtale/neonatale

Country Status (6)

Country Link
EP (1) EP4054324A1 (fr)
JP (1) JP2023500896A (fr)
CN (1) CN114630579A (fr)
AU (1) AU2019473345A1 (fr)
CA (1) CA3162639A1 (fr)
WO (1) WO2021091539A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023081872A1 (fr) * 2021-11-08 2023-05-11 Rallybio Ipa, Llc Dosages pour la quantification d'anticorps anti-hpa-1a

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US661108A (en) 1899-12-04 1900-11-06 Albert Schmitz Manufacture of compound tubes.
US4873191A (en) 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US4870009A (en) 1982-11-22 1989-09-26 The Salk Institute For Biological Studies Method of obtaining gene product through the generation of transgenic animals
US4736866B1 (en) 1984-06-22 1988-04-12 Transgenic non-human mammals
US4873316A (en) 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
AU6505690A (en) 1989-09-26 1991-04-28 Richard R Behringer Erythroid-specific gene expression system
DE4000939A1 (de) 1990-01-15 1991-07-18 Brem Gottfried Prof Dr Dr Verfahren zur antikoerpergewinnung
AU1228592A (en) 1991-01-11 1992-08-17 American Red Cross Expression of active human protein c in mammary tissue of transgenic animals
WO1998035689A1 (fr) 1997-02-14 1998-08-20 American Red Cross Expression du facteur ix humain actif, dans un tissu mammaire d'animal transgenique
US6331658B1 (en) 1993-04-20 2001-12-18 Integris Baptist Medical Center, Inc. Genetically engineered mammals for use as organ donors
US5639940A (en) 1994-03-03 1997-06-17 Pharmaceutical Proteins Ltd. Production of fibrinogen in transgenic animals
US6204431B1 (en) 1994-03-09 2001-03-20 Abbott Laboratories Transgenic non-human mammals expressing heterologous glycosyltransferase DNA sequences produce oligosaccharides and glycoproteins in their milk
US5959171A (en) 1994-08-17 1999-09-28 Pharming B.V. Method for the production of biologically active polypeptides in a mammal's
US5880327A (en) 1994-09-21 1999-03-09 American National Red Cross Transgenic mammals expressing human coagulation factor VIII
CA2211993A1 (fr) * 1995-01-31 1996-08-08 The Rockefeller University Identification de la proteine membranaire, integrale dec (cellules dendritiques et epitheliales, 205 kda), un recepteur a domaines lectiniques de type c, des acides nucleiques codant dec, ainsi que ses applications
US6339183B1 (en) 1995-06-05 2002-01-15 New York University Transgenic mammals expressing heterologous DNA in urothelium and isolation of biologically active molecules from urine
US6166288A (en) 1995-09-27 2000-12-26 Nextran Inc. Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor
WO1997012513A1 (fr) 1995-10-02 1997-04-10 Duke University Souris presentant une deficience dans l'expression du transporteur de dopamine
US6066778A (en) * 1996-11-06 2000-05-23 The Regents Of The University Of Michigan Transgenic mice expressing APC resistant factor V
KR100646816B1 (ko) 1998-01-08 2006-11-17 다이이찌 세이야꾸 가부시기가이샤 유전자 넉인 동물
AU4951300A (en) 1999-05-31 2000-12-18 Chugai Research Institute For Molecular Medicine, Inc. Lkb1 gene knockout animals
CA3031206A1 (fr) * 2016-07-29 2018-02-01 Regeneron Pharmaceuticals, Inc. Mutations entrainant l'expression de la fibrilline 1 pour modeliser le syndrome progeroide neonatal avec lipodystrophie congenitale
CN108794631A (zh) * 2018-06-12 2018-11-13 广州血液中心 一种鼠源性抗鼠cd36单克隆抗体的制备方法
CN110384074A (zh) * 2019-07-15 2019-10-29 广州医科大学 一种Kir7.1基因失活的小鼠模型及其构建方法

Also Published As

Publication number Publication date
EP4054324A1 (fr) 2022-09-14
CN114630579A (zh) 2022-06-14
AU2019473345A1 (en) 2022-05-05
WO2021091539A1 (fr) 2021-05-14
JP2023500896A (ja) 2023-01-11

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Legal Events

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Effective date: 20231026

EEER Examination request

Effective date: 20231026

EEER Examination request

Effective date: 20231026