CA3161589A1 - Method for producing oligonucleic acid compound - Google Patents

Method for producing oligonucleic acid compound

Info

Publication number
CA3161589A1
CA3161589A1 CA3161589A CA3161589A CA3161589A1 CA 3161589 A1 CA3161589 A1 CA 3161589A1 CA 3161589 A CA3161589 A CA 3161589A CA 3161589 A CA3161589 A CA 3161589A CA 3161589 A1 CA3161589 A1 CA 3161589A1
Authority
CA
Canada
Prior art keywords
compound
general formula
alkyl
long
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3161589A
Other languages
English (en)
French (fr)
Inventor
Yutaro KOTOBUKI
Koki Kato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of CA3161589A1 publication Critical patent/CA3161589A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3161589A 2019-11-13 2020-11-13 Method for producing oligonucleic acid compound Pending CA3161589A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019-205628 2019-11-13
JP2019205628 2019-11-13
PCT/JP2020/042506 WO2021095875A1 (ja) 2019-11-13 2020-11-13 オリゴ核酸化合物の製造方法

Publications (1)

Publication Number Publication Date
CA3161589A1 true CA3161589A1 (en) 2021-05-20

Family

ID=75912390

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3161589A Pending CA3161589A1 (en) 2019-11-13 2020-11-13 Method for producing oligonucleic acid compound

Country Status (7)

Country Link
US (1) US12600744B2 (https=)
EP (1) EP4059943A4 (https=)
JP (2) JP7669280B2 (https=)
KR (1) KR20220097986A (https=)
CN (1) CN114981280A (https=)
CA (1) CA3161589A1 (https=)
WO (1) WO2021095875A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240254158A1 (en) * 2021-04-28 2024-08-01 Nippon Shinyaku Co., Ltd. Method for producing oligonucleic acid compound
CA3244382A1 (en) * 2021-12-27 2025-02-26 Nippon Shinyaku Co., Ltd. PROCESS FOR THE PRODUCTION OF OLIGONUCLEIC ACID COMPOUNDS

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2130844A5 (https=) 1971-03-23 1972-11-10 Commissariat Energie Atomique
JPS5668388A (en) 1979-11-10 1981-06-09 Norin Suisansyo Shokuhin Sogo Kenkyusho Production of cell body of spirulina algae
JP3398378B2 (ja) 1989-12-20 2003-04-21 アンチビラルス・インコーポレイテツド リン含有キラルインターサブユニットリンケージを有する非電荷モルホリノ―基体ポリマー
US6313301B1 (en) 1997-08-13 2001-11-06 Takeda Chemical Industries, Ltd. Thienopyridine derivatives, their intermediates and production thereof
US6274725B1 (en) 1998-06-02 2001-08-14 Isis Pharmaceuticals, Inc. Activators for oligonucleotide synthesis
JP2005529957A (ja) 2002-06-13 2005-10-06 ローディア インク． リン・ジアミダイト合成物を生成する工程
US8067571B2 (en) 2005-07-13 2011-11-29 Avi Biopharma, Inc. Antibacterial antisense oligonucleotide and method
KR100886139B1 (ko) 2007-11-13 2009-02-27 주식회사 삼천리제약 올리고뉴클레오타이드의 제조방법
MX2010004955A (es) 2007-11-15 2010-06-30 Avi Biopharma Inc Metodo de sintesis de oligomeros de morfolina.
JP5548852B2 (ja) 2009-05-29 2014-07-16 国立大学法人東京農工大学 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法
RS55610B1 (sr) 2010-09-30 2017-06-30 Nippon Shinyaku Co Ltd Derivat morfolino nukleinske kiseline
JP5979139B2 (ja) 2011-05-17 2016-08-24 味の素株式会社 オリゴヌクレオチドの製造方法
EA202090338A1 (ru) 2011-11-18 2021-04-30 Сарепта Терапьютикс, Инк. Функционально-модифицированные олигонуклеотиды и их субъединицы
US10066228B2 (en) 2011-11-30 2018-09-04 Sarepta Therapeutics, Inc. Oligonucleotides for treating expanded repeat diseases
EP2816053B1 (en) 2012-02-17 2021-03-24 Ajinomoto Co., Inc. Base-protected oligonucleotide
EP2921499B1 (en) 2012-11-14 2020-01-22 Takeda Pharmaceutical Company Limited Method for liquid-phase synthesis of nucleic acids
WO2014189142A1 (ja) 2013-05-24 2014-11-27 味の素株式会社 モルフォリノオリゴヌクレオチドの製造方法
JP6673211B2 (ja) 2014-10-14 2020-03-25 味の素株式会社 モルフォリノオリゴヌクレオチドの製造方法
EP3266792B1 (en) 2015-03-04 2020-12-30 Jitsubo Co., Ltd. Peptide synthesis method
JP2019534862A (ja) * 2016-09-20 2019-12-05 ザ リージェンツ オブ ザ ユニヴァーシティ オブ コロラド，ア ボディ コーポレイト ホスホルアミダイト化学を使用する骨格修飾モルホリノオリゴヌクレオチド及びキメラの合成
CN112384520B (zh) * 2018-05-10 2024-06-11 日本新药株式会社 寡核苷酸化合物的制造方法

Also Published As

Publication number Publication date
CN114981280A (zh) 2022-08-30
JPWO2021095875A1 (https=) 2021-05-20
EP4059943A4 (en) 2024-01-31
US12600744B2 (en) 2026-04-14
US20230014840A1 (en) 2023-01-19
EP4059943A1 (en) 2022-09-21
JP7669280B2 (ja) 2025-04-28
JP2025111536A (ja) 2025-07-30
WO2021095875A1 (ja) 2021-05-20
KR20220097986A (ko) 2022-07-08

Similar Documents

Publication Publication Date Title
CN112384520B (zh) 寡核苷酸化合物的制造方法
CA2647316C (en) Process for preparation of hiv protease inhibitors
JP2025111536A (ja) オリゴ核酸化合物の製造方法
JP2025128175A (ja) オリゴ核酸化合物の製造方法
JP7825613B2 (ja) オリゴ核酸化合物の製造方法
HK40081457A (en) Method for producing oligonucleic acid compound
JP6429264B2 (ja) ボラノホスフェート化合物、及び核酸オリゴマー
HK40038624A (en) Method for producing oligonucleic acid compound
HK40072767A (en) Method for producing oligonucleic acid compound
JP7776154B2 (ja) ホスホロチオエート及びボラノホスフェートを含むキメラ型核酸オリゴマー、及びその製造方法
US8193337B2 (en) Oxidation process
US20250042932A1 (en) Method for producing polynucleotides
HK40102206A (en) Method for producing oligonucleic acid compound
Chen et al. A novel and efficient synthesis of 3′-amino-3′-deoxyadenosine
WO1998021226A1 (en) H-phosphonate oligonucleotide derivative and process for producing the derivative

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20231221

D15 Examination report completed

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D15-D126 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: EXAMINER'S REPORT

Effective date: 20250416

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT RECEIVED - RESPONSE TO EXAMINER'S REQUISITION

Effective date: 20250710

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20250715

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT DETERMINED COMPLIANT

Effective date: 20250718

P13 Application amended

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P13-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION AMENDED

Effective date: 20250718

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 5TH ANNIV.) - STANDARD

Year of fee payment: 5

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250923

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250923

D15 Examination report completed

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D15-D126 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: EXAMINER'S REPORT

Effective date: 20251231

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT RECEIVED - RESPONSE TO EXAMINER'S REQUISITION

Effective date: 20260316

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT DETERMINED COMPLIANT

Effective date: 20260317

P13 Application amended

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P13-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION AMENDED

Effective date: 20260317

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20260317