CA3161589A1 - Method for producing oligonucleic acid compound - Google Patents

Method for producing oligonucleic acid compound

Info

Publication number
CA3161589A1
CA3161589A1 CA3161589A CA3161589A CA3161589A1 CA 3161589 A1 CA3161589 A1 CA 3161589A1 CA 3161589 A CA3161589 A CA 3161589A CA 3161589 A CA3161589 A CA 3161589A CA 3161589 A1 CA3161589 A1 CA 3161589A1
Authority
CA
Canada
Prior art keywords
compound
general formula
alkyl
long
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3161589A
Other languages
English (en)
French (fr)
Inventor
Yutaro KOTOBUKI
Koki Kato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of CA3161589A1 publication Critical patent/CA3161589A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3161589A 2019-11-13 2020-11-13 Method for producing oligonucleic acid compound Pending CA3161589A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019-205628 2019-11-13
JP2019205628 2019-11-13
PCT/JP2020/042506 WO2021095875A1 (ja) 2019-11-13 2020-11-13 オリゴ核酸化合物の製造方法

Publications (1)

Publication Number Publication Date
CA3161589A1 true CA3161589A1 (en) 2021-05-20

Family

ID=75912390

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3161589A Pending CA3161589A1 (en) 2019-11-13 2020-11-13 Method for producing oligonucleic acid compound

Country Status (7)

Country Link
US (1) US12600744B2 (https=)
EP (1) EP4059943A4 (https=)
JP (2) JP7669280B2 (https=)
KR (1) KR20220097986A (https=)
CN (1) CN114981280A (https=)
CA (1) CA3161589A1 (https=)
WO (1) WO2021095875A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7825613B2 (ja) * 2021-04-28 2026-03-06 日本新薬株式会社 オリゴ核酸化合物の製造方法
EP4458833A4 (en) * 2021-12-27 2025-12-31 Nippon Shinyaku Co Ltd PROCESS FOR THE PRODUCTION OF OLIGONUCLEIC ACID COMPOUNDS

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2130844A5 (https=) 1971-03-23 1972-11-10 Commissariat Energie Atomique
JPS5668388A (en) 1979-11-10 1981-06-09 Norin Suisansyo Shokuhin Sogo Kenkyusho Production of cell body of spirulina algae
AU655164B2 (en) 1989-12-20 1994-12-08 Antivirals Inc. Uncharged morpholino-based polymers having phosphorous-containing chiral intersubunit linkages
US6313301B1 (en) 1997-08-13 2001-11-06 Takeda Chemical Industries, Ltd. Thienopyridine derivatives, their intermediates and production thereof
US6274725B1 (en) 1998-06-02 2001-08-14 Isis Pharmaceuticals, Inc. Activators for oligonucleotide synthesis
CN100338076C (zh) 2002-06-13 2007-09-19 罗狄亚公司 制备亚磷酰二胺化合物的方法
US8067571B2 (en) 2005-07-13 2011-11-29 Avi Biopharma, Inc. Antibacterial antisense oligonucleotide and method
KR100886139B1 (ko) 2007-11-13 2009-02-27 주식회사 삼천리제약 올리고뉴클레오타이드의 제조방법
RU2606627C2 (ru) 2007-11-15 2017-01-10 Серепта Терапьютикс,Инк. Способ синтеза морфолиновых олигомеров
JP5548852B2 (ja) 2009-05-29 2014-07-16 国立大学法人東京農工大学 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法
ES2607603T3 (es) 2010-09-30 2017-04-03 Nippon Shinyaku Co., Ltd. Derivado de ácido morfolino nucleico
DK2711370T3 (en) 2011-05-17 2018-02-26 Ajinomoto Kk PROCEDURE FOR THE PREPARATION OF OLIGONUCLEOTIDES
HK1201514A1 (en) * 2011-11-18 2015-09-04 Sarepta Therapeutics, Inc. Functionally-modified oligonucleotides and subunits thereof
US10066228B2 (en) 2011-11-30 2018-09-04 Sarepta Therapeutics, Inc. Oligonucleotides for treating expanded repeat diseases
EP2816053B1 (en) 2012-02-17 2021-03-24 Ajinomoto Co., Inc. Base-protected oligonucleotide
US10214555B2 (en) 2012-11-14 2019-02-26 Takeda Pharmaceutical Company Limitjed Method for liquid-phase synthesis of nucleic acid
DK3015467T3 (da) 2013-05-24 2025-02-10 Ajinomoto Kk Morpholino-oligonukleotidfremstillingsfremgangsmåde
WO2016060135A1 (ja) 2014-10-14 2016-04-21 味の素株式会社 モルフォリノオリゴヌクレオチドの製造方法
CN107406480B (zh) 2015-03-04 2022-06-24 Jitsubo株式会社 肽合成方法
AU2017330276B2 (en) 2016-09-20 2022-01-20 The Regents Of The University Of Colorado, A Body Corporate Synthesis of backbone modified morpholino oligonucleotides and chimeras using phosphoramidite chemistry
CA3099778A1 (en) * 2018-05-10 2019-11-14 Nippon Shinyaku Co., Ltd. Method for preparing oligonucleic acid compound

Also Published As

Publication number Publication date
JP2025111536A (ja) 2025-07-30
EP4059943A1 (en) 2022-09-21
US12600744B2 (en) 2026-04-14
WO2021095875A1 (ja) 2021-05-20
KR20220097986A (ko) 2022-07-08
US20230014840A1 (en) 2023-01-19
JP7669280B2 (ja) 2025-04-28
JPWO2021095875A1 (https=) 2021-05-20
EP4059943A4 (en) 2024-01-31
CN114981280A (zh) 2022-08-30

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