CA3136369A1 - Compounds and methods for the treatment of ocular disorders - Google Patents
Compounds and methods for the treatment of ocular disorders Download PDFInfo
- Publication number
- CA3136369A1 CA3136369A1 CA3136369A CA3136369A CA3136369A1 CA 3136369 A1 CA3136369 A1 CA 3136369A1 CA 3136369 A CA3136369 A CA 3136369A CA 3136369 A CA3136369 A CA 3136369A CA 3136369 A1 CA3136369 A1 CA 3136369A1
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- Prior art keywords
- alkyl
- compound
- optionally substituted
- heteroalkyl
- oxy
- Prior art date
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- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 229960004559 theobromine Drugs 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000001984 thiazolidinyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 125000005985 thienyl[1,3]dithianyl group Chemical group 0.000 description 1
- 125000004055 thiomethyl group Chemical group [H]SC([H])([H])* 0.000 description 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
- RZWIIPASKMUIAC-VQTJNVASSA-N thromboxane Chemical compound CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC RZWIIPASKMUIAC-VQTJNVASSA-N 0.000 description 1
- 150000003595 thromboxanes Chemical class 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- LBLYYCQCTBFVLH-UHFFFAOYSA-M toluenesulfonate group Chemical group C=1(C(=CC=CC1)S(=O)(=O)[O-])C LBLYYCQCTBFVLH-UHFFFAOYSA-M 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
- 125000005455 trithianyl group Chemical group 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Ophthalmology & Optometry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962835975P | 2019-04-18 | 2019-04-18 | |
| US62/835,975 | 2019-04-18 | ||
| US202062966482P | 2020-01-27 | 2020-01-27 | |
| US62/966,482 | 2020-01-27 | ||
| PCT/IB2020/000312 WO2020212760A2 (en) | 2019-04-18 | 2020-04-16 | Compounds and methods for the treatment of ocular disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3136369A1 true CA3136369A1 (en) | 2020-10-22 |
Family
ID=72837068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3136369A Pending CA3136369A1 (en) | 2019-04-18 | 2020-04-16 | Compounds and methods for the treatment of ocular disorders |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11643429B2 (de) |
| EP (1) | EP3955937A4 (de) |
| JP (1) | JP2022529315A (de) |
| KR (1) | KR20210154214A (de) |
| CN (1) | CN114007625A (de) |
| AU (1) | AU2020259997A1 (de) |
| CA (1) | CA3136369A1 (de) |
| IL (1) | IL287280A (de) |
| WO (1) | WO2020212760A2 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3136369A1 (en) | 2019-04-18 | 2020-10-22 | Azura Ophthalmics Ltd. | Compounds and methods for the treatment of ocular disorders |
| JP2022530322A (ja) | 2019-04-18 | 2022-06-29 | アズーラ オフサルミックス エルティーディー． | 眼障害を処置するための化合物および方法 |
| AU2021363702A1 (en) * | 2020-10-21 | 2023-06-15 | Azura Ophthalmics Ltd. | Compounds and methods for the treatment of ocular disorders |
| WO2023067387A2 (en) * | 2021-10-20 | 2023-04-27 | Azura Ophthalmics Ltd. | Compounds and methods for the treatment of dermal and ocular disorders |
| KR20240016209A (ko) | 2022-07-28 | 2024-02-06 | 스미또모 가가꾸 가부시키가이샤 | 편광 필름의 제조 방법 및 제조 장치 |
| WO2024101918A1 (ko) * | 2022-11-11 | 2024-05-16 | 주식회사 메디치바이오 | 리포-하이드록삼산 유도체 및 이의 약학적 용도 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992006991A1 (fr) * | 1990-10-15 | 1992-04-30 | Taisho Pharmaceutical Co., Ltd. | Erythromycine modifiee en 2' ou derive de cette substance |
| WO1995018604A1 (en) * | 1994-01-11 | 1995-07-13 | Ciba-Geigy Ag | Topical treatment of ocular photophobia |
| KR100477070B1 (ko) | 1994-03-25 | 2006-04-21 | 이소테크니카 인코포레이티드 | 중수소화작용에의한의약품의효능강화법 |
| US6334997B1 (en) | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| US6239113B1 (en) | 1999-03-31 | 2001-05-29 | Insite Vision, Incorporated | Topical treatment or prevention of ocular infections |
| US7056893B2 (en) | 1999-03-31 | 2006-06-06 | Insite Vision, Inc. | Topical treatment for prevention of ocular infections |
| MXPA03009786A (es) * | 2001-04-27 | 2004-01-29 | Pfizer Prod Inc | Procedimiento para preparar derivados de 9-desoxo-9a-aza-9a-homoeritromicina a 4"-sustituidos. |
| FR2832637B1 (fr) * | 2001-06-07 | 2004-07-30 | Lefaix Marie Therese Droy | Utilisation d'un antioxydant pour la fabrication d'un medicament destine au traitement des affections oculaires de surface |
| NZ535354A (en) * | 2002-02-15 | 2008-01-31 | Merckle Gmbh | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
| GB0310980D0 (en) * | 2003-05-13 | 2003-06-18 | Glaxo Group Ltd | Novel compounds |
| GB0310984D0 (en) * | 2003-05-13 | 2003-06-18 | Glaxo Group Ltd | Novel compounds |
| GB0310962D0 (en) * | 2003-05-13 | 2003-06-18 | Glaxo Group Ltd | Novel compounds |
| CN1837225A (zh) * | 2005-08-23 | 2006-09-27 | 济南思创生物技术有限公司 | 阿奇霉素衍生物及其制法和药物应用 |
| GB0609373D0 (en) * | 2006-05-11 | 2006-06-21 | Glaxo Group Ltd | Macrolones |
| US20110281812A1 (en) * | 2009-01-30 | 2011-11-17 | Sulejman Alihodzic | Compounds |
| CA2789847A1 (en) * | 2010-02-15 | 2011-08-18 | Synovo Gmbh | Kinase modulators for the treatment of cancer |
| US20140142055A1 (en) * | 2011-06-29 | 2014-05-22 | Insite Vision Corporation | Methods of treating recurrent meibomian glands disorder and thereby decreasing the frequency of recurrence |
| CA2869461A1 (en) * | 2012-03-27 | 2013-10-03 | Michael W. BURNET | Anti-inflammatory macrolides |
| US9463201B2 (en) | 2014-10-19 | 2016-10-11 | M.G. Therapeutics Ltd | Compositions and methods for the treatment of meibomian gland dysfunction |
| MA44737A (fr) | 2016-04-19 | 2021-04-07 | Azura Ophthalmics Ltd | Compositions pour le traitement de troubles liés à l'hyperkératose |
| WO2018161039A1 (en) * | 2017-03-03 | 2018-09-07 | Synovo Gmbh | Novel anti-infective and anti-inflammatory compounds |
| KR102541236B1 (ko) | 2017-03-29 | 2023-06-08 | 아주라 오프탈믹스 엘티디 | 마이봄샘 지질 분비 증가를 위한 작용제 |
| WO2018215638A1 (en) * | 2017-05-26 | 2018-11-29 | Novaliq Gmbh | Pharmaceutical compositions comprising azithromycin |
| CA3136369A1 (en) | 2019-04-18 | 2020-10-22 | Azura Ophthalmics Ltd. | Compounds and methods for the treatment of ocular disorders |
-
2020
- 2020-04-16 CA CA3136369A patent/CA3136369A1/en active Pending
- 2020-04-16 EP EP20790702.3A patent/EP3955937A4/de active Pending
- 2020-04-16 WO PCT/IB2020/000312 patent/WO2020212760A2/en active Application Filing
- 2020-04-16 JP JP2021559179A patent/JP2022529315A/ja active Pending
- 2020-04-16 AU AU2020259997A patent/AU2020259997A1/en active Pending
- 2020-04-16 KR KR1020217037540A patent/KR20210154214A/ko unknown
- 2020-04-16 CN CN202080044806.4A patent/CN114007625A/zh active Pending
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2021
- 2021-04-05 US US17/222,821 patent/US11643429B2/en active Active
- 2021-10-14 IL IL287280A patent/IL287280A/en unknown
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2023
- 2023-03-06 US US18/117,759 patent/US20230348517A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US11643429B2 (en) | 2023-05-09 |
| EP3955937A2 (de) | 2022-02-23 |
| KR20210154214A (ko) | 2021-12-20 |
| EP3955937A4 (de) | 2023-01-18 |
| JP2022529315A (ja) | 2022-06-21 |
| WO2020212760A2 (en) | 2020-10-22 |
| CN114007625A (zh) | 2022-02-01 |
| US20230348517A1 (en) | 2023-11-02 |
| AU2020259997A1 (en) | 2021-11-25 |
| US20210230205A1 (en) | 2021-07-29 |
| IL287280A (en) | 2021-12-01 |
| WO2020212760A3 (en) | 2021-02-25 |
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