CA3131146A1 - Solid polymorphs of a flna-binding compound and its hydrochloride salts - Google Patents

Solid polymorphs of a flna-binding compound and its hydrochloride salts Download PDF

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Publication number
CA3131146A1
CA3131146A1 CA3131146A CA3131146A CA3131146A1 CA 3131146 A1 CA3131146 A1 CA 3131146A1 CA 3131146 A CA3131146 A CA 3131146A CA 3131146 A CA3131146 A CA 3131146A CA 3131146 A1 CA3131146 A1 CA 3131146A1
Authority
CA
Canada
Prior art keywords
crystalline
triazaspiro
decan
ray powder
powder diffraction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3131146A
Other languages
English (en)
French (fr)
Inventor
Michael Zamloot
Lindsay Burns Barbier
Shawn Anthony Kucera
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pain Therapeutics Inc
Original Assignee
Pain Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pain Therapeutics Inc filed Critical Pain Therapeutics Inc
Publication of CA3131146A1 publication Critical patent/CA3131146A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA3131146A 2019-02-21 2020-02-21 Solid polymorphs of a flna-binding compound and its hydrochloride salts Pending CA3131146A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962808609P 2019-02-21 2019-02-21
US62/808,609 2019-02-21
PCT/US2020/019305 WO2020172584A1 (en) 2019-02-21 2020-02-21 Solid polymorphs of a flna-binding compound and its hydrochloride salts

Publications (1)

Publication Number Publication Date
CA3131146A1 true CA3131146A1 (en) 2020-08-27

Family

ID=72141575

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3131146A Pending CA3131146A1 (en) 2019-02-21 2020-02-21 Solid polymorphs of a flna-binding compound and its hydrochloride salts

Country Status (10)

Country Link
US (4) US11370791B2 (https=)
EP (1) EP3927707A4 (https=)
JP (2) JP2022523196A (https=)
KR (1) KR20210135530A (https=)
CN (2) CN114072406B (https=)
AU (1) AU2020224678B2 (https=)
BR (1) BR112021016622A2 (https=)
CA (1) CA3131146A1 (https=)
IL (1) IL285763A (https=)
WO (1) WO2020172584A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020172584A1 (en) 2019-02-21 2020-08-27 Pain Therapeutics, Inc. Solid polymorphs of a flna-binding compound and its hydrochloride salts
US20220233512A1 (en) * 2020-11-03 2022-07-28 Cassava Sciences, Inc. Inhibiting an immune response mediated by one or more of tlr2, rage, ccr5, cxcr4 and cd4

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004014304A1 (de) 2004-03-22 2005-10-06 Grünenthal GmbH Substituierte 1,4,8- Triazaspiro[4,5]decan-2-on-Verbindungen
US8653068B2 (en) * 2009-10-30 2014-02-18 Pain Therapeutics, Inc. Filamin A binding anti-inflammatory and analgesic
US9340558B2 (en) * 2007-11-02 2016-05-17 Pain Therapeutics Inc. Filamin a binding anti-inflammatory and analgesic
US8614324B2 (en) * 2008-10-31 2013-12-24 Pain Therapeutics, Inc. Filamin A binding anti-inflammatory and analgesic
WO2010051497A1 (en) * 2008-10-31 2010-05-06 Pain Therapeutics, Inc. Filamin a binding anti-inflammatory and analgesic
EP2549873A1 (en) * 2010-03-25 2013-01-30 Merck Sharp & Dohme Corp. Novel spiro imidazolones as glucagon receptor antagonists, compositions, and methods for their use
WO2014012054A1 (en) 2012-07-13 2014-01-16 Pain Therapeutics, Inc. Alzheimer's disease assay in a living patent
EP2882428B1 (en) * 2012-07-13 2019-01-16 Pain Therapeutics, Inc. A method of inhibiting tau phosphorylation
US9433604B2 (en) * 2013-10-08 2016-09-06 Pain Therapeutics Inc. Method for inhibiting growth of cancer cells
WO2020172584A1 (en) 2019-02-21 2020-08-27 Pain Therapeutics, Inc. Solid polymorphs of a flna-binding compound and its hydrochloride salts

Also Published As

Publication number Publication date
JP2022523196A (ja) 2022-04-21
WO2020172584A1 (en) 2020-08-27
US12391693B2 (en) 2025-08-19
AU2020224678A1 (en) 2021-09-16
US20240400566A1 (en) 2024-12-05
JP2024054139A (ja) 2024-04-16
US20220340574A1 (en) 2022-10-27
CN114072406B (zh) 2025-03-18
EP3927707A4 (en) 2022-11-09
US12065440B2 (en) 2024-08-20
US11370791B2 (en) 2022-06-28
US20200270250A1 (en) 2020-08-27
CN114072406A (zh) 2022-02-18
CN120004896A (zh) 2025-05-16
AU2020224678B2 (en) 2024-03-14
NZ779310A (en) 2024-01-26
BR112021016622A2 (pt) 2021-11-03
IL285763A (en) 2021-10-31
EP3927707A1 (en) 2021-12-29
KR20210135530A (ko) 2021-11-15
US20250084083A1 (en) 2025-03-13

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