BR112021016622A2 - Polimorfos sólidos de um composto de ligação de flna e seus sais de cloridrato - Google Patents
Polimorfos sólidos de um composto de ligação de flna e seus sais de cloridratoInfo
- Publication number
- BR112021016622A2 BR112021016622A2 BR112021016622A BR112021016622A BR112021016622A2 BR 112021016622 A2 BR112021016622 A2 BR 112021016622A2 BR 112021016622 A BR112021016622 A BR 112021016622A BR 112021016622 A BR112021016622 A BR 112021016622A BR 112021016622 A2 BR112021016622 A2 BR 112021016622A2
- Authority
- BR
- Brazil
- Prior art keywords
- polymorphs
- flna
- binding compound
- hydrochloride salts
- solid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962808609P | 2019-02-21 | 2019-02-21 | |
| PCT/US2020/019305 WO2020172584A1 (en) | 2019-02-21 | 2020-02-21 | Solid polymorphs of a flna-binding compound and its hydrochloride salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021016622A2 true BR112021016622A2 (pt) | 2021-11-03 |
Family
ID=72141575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021016622A BR112021016622A2 (pt) | 2019-02-21 | 2020-02-21 | Polimorfos sólidos de um composto de ligação de flna e seus sais de cloridrato |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US11370791B2 (https=) |
| EP (1) | EP3927707A4 (https=) |
| JP (2) | JP2022523196A (https=) |
| KR (1) | KR20210135530A (https=) |
| CN (2) | CN114072406B (https=) |
| AU (1) | AU2020224678B2 (https=) |
| BR (1) | BR112021016622A2 (https=) |
| CA (1) | CA3131146A1 (https=) |
| IL (1) | IL285763A (https=) |
| WO (1) | WO2020172584A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020172584A1 (en) | 2019-02-21 | 2020-08-27 | Pain Therapeutics, Inc. | Solid polymorphs of a flna-binding compound and its hydrochloride salts |
| US20220233512A1 (en) * | 2020-11-03 | 2022-07-28 | Cassava Sciences, Inc. | Inhibiting an immune response mediated by one or more of tlr2, rage, ccr5, cxcr4 and cd4 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004014304A1 (de) | 2004-03-22 | 2005-10-06 | Grünenthal GmbH | Substituierte 1,4,8- Triazaspiro[4,5]decan-2-on-Verbindungen |
| US8653068B2 (en) * | 2009-10-30 | 2014-02-18 | Pain Therapeutics, Inc. | Filamin A binding anti-inflammatory and analgesic |
| US9340558B2 (en) * | 2007-11-02 | 2016-05-17 | Pain Therapeutics Inc. | Filamin a binding anti-inflammatory and analgesic |
| US8614324B2 (en) * | 2008-10-31 | 2013-12-24 | Pain Therapeutics, Inc. | Filamin A binding anti-inflammatory and analgesic |
| WO2010051497A1 (en) * | 2008-10-31 | 2010-05-06 | Pain Therapeutics, Inc. | Filamin a binding anti-inflammatory and analgesic |
| EP2549873A1 (en) * | 2010-03-25 | 2013-01-30 | Merck Sharp & Dohme Corp. | Novel spiro imidazolones as glucagon receptor antagonists, compositions, and methods for their use |
| WO2014012054A1 (en) | 2012-07-13 | 2014-01-16 | Pain Therapeutics, Inc. | Alzheimer's disease assay in a living patent |
| EP2882428B1 (en) * | 2012-07-13 | 2019-01-16 | Pain Therapeutics, Inc. | A method of inhibiting tau phosphorylation |
| US9433604B2 (en) * | 2013-10-08 | 2016-09-06 | Pain Therapeutics Inc. | Method for inhibiting growth of cancer cells |
| WO2020172584A1 (en) | 2019-02-21 | 2020-08-27 | Pain Therapeutics, Inc. | Solid polymorphs of a flna-binding compound and its hydrochloride salts |
-
2020
- 2020-02-21 WO PCT/US2020/019305 patent/WO2020172584A1/en not_active Ceased
- 2020-02-21 CA CA3131146A patent/CA3131146A1/en active Pending
- 2020-02-21 KR KR1020217030333A patent/KR20210135530A/ko not_active Ceased
- 2020-02-21 CN CN202080030057.XA patent/CN114072406B/zh active Active
- 2020-02-21 CN CN202510171428.0A patent/CN120004896A/zh active Pending
- 2020-02-21 JP JP2021549470A patent/JP2022523196A/ja active Pending
- 2020-02-21 US US16/798,041 patent/US11370791B2/en active Active
- 2020-02-21 AU AU2020224678A patent/AU2020224678B2/en active Active
- 2020-02-21 BR BR112021016622A patent/BR112021016622A2/pt unknown
- 2020-02-21 EP EP20759180.1A patent/EP3927707A4/en active Pending
-
2021
- 2021-08-22 IL IL285763A patent/IL285763A/en unknown
-
2022
- 2022-06-27 US US17/850,198 patent/US12065440B2/en active Active
-
2024
- 2024-01-18 JP JP2024005868A patent/JP2024054139A/ja active Pending
- 2024-08-13 US US18/802,950 patent/US20240400566A1/en active Pending
- 2024-11-21 US US18/955,947 patent/US12391693B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022523196A (ja) | 2022-04-21 |
| WO2020172584A1 (en) | 2020-08-27 |
| US12391693B2 (en) | 2025-08-19 |
| AU2020224678A1 (en) | 2021-09-16 |
| US20240400566A1 (en) | 2024-12-05 |
| JP2024054139A (ja) | 2024-04-16 |
| US20220340574A1 (en) | 2022-10-27 |
| CN114072406B (zh) | 2025-03-18 |
| EP3927707A4 (en) | 2022-11-09 |
| US12065440B2 (en) | 2024-08-20 |
| US11370791B2 (en) | 2022-06-28 |
| US20200270250A1 (en) | 2020-08-27 |
| CN114072406A (zh) | 2022-02-18 |
| CN120004896A (zh) | 2025-05-16 |
| AU2020224678B2 (en) | 2024-03-14 |
| NZ779310A (en) | 2024-01-26 |
| IL285763A (en) | 2021-10-31 |
| EP3927707A1 (en) | 2021-12-29 |
| KR20210135530A (ko) | 2021-11-15 |
| CA3131146A1 (en) | 2020-08-27 |
| US20250084083A1 (en) | 2025-03-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] |