CA3111565A1 - Hybrid amphotericin b derivatives with reduced toxicity - Google Patents

Hybrid amphotericin b derivatives with reduced toxicity Download PDF

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Publication number
CA3111565A1
CA3111565A1 CA3111565A CA3111565A CA3111565A1 CA 3111565 A1 CA3111565 A1 CA 3111565A1 CA 3111565 A CA3111565 A CA 3111565A CA 3111565 A CA3111565 A CA 3111565A CA 3111565 A1 CA3111565 A1 CA 3111565A1
Authority
CA
Canada
Prior art keywords
compound
alkyl
group
heterocyclyl
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3111565A
Other languages
English (en)
French (fr)
Inventor
Martin D. Burke
Jiabao Zhang
KHANDELWAL (DECEASED), Anuj
Anna Santamaria
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Illinois System
Original Assignee
University of Illinois System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Illinois System filed Critical University of Illinois System
Publication of CA3111565A1 publication Critical patent/CA3111565A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CA3111565A 2018-09-07 2019-09-06 Hybrid amphotericin b derivatives with reduced toxicity Pending CA3111565A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862728203P 2018-09-07 2018-09-07
US62/728,203 2018-09-07
PCT/US2019/049971 WO2020051465A1 (en) 2018-09-07 2019-09-06 Hybrid amphotericin b derivatives with reduced toxicity

Publications (1)

Publication Number Publication Date
CA3111565A1 true CA3111565A1 (en) 2020-03-12

Family

ID=69719049

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3111565A Pending CA3111565A1 (en) 2018-09-07 2019-09-06 Hybrid amphotericin b derivatives with reduced toxicity

Country Status (8)

Country Link
US (1) US11198705B2 (https=)
EP (1) EP3846823A4 (https=)
JP (1) JP7477177B2 (https=)
KR (1) KR102893040B1 (https=)
CN (1) CN113056274A (https=)
AU (1) AU2019335409B2 (https=)
CA (1) CA3111565A1 (https=)
WO (1) WO2020051465A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3111565A1 (en) 2018-09-07 2020-03-12 The Board Of Trustees Of The University Of Illinois Hybrid amphotericin b derivatives with reduced toxicity
KR20220058547A (ko) * 2019-08-08 2022-05-09 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 감소된 독성을 갖는 하이브리드 암포테리신 b 유도체
AU2021325676A1 (en) * 2020-08-10 2023-03-30 The Board Of Trustees Of The University Of Illinois Hybrid amide derivatives of amphotericin B

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102548341B1 (ko) * 2013-10-07 2023-06-26 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 개선된 치료 지수를 갖는 암포테리신 b 유도체
ES2749927T3 (es) * 2014-05-16 2020-03-24 Univ Illinois Derivado de anfotericina b con toxicidad reducida
MA39568A1 (fr) * 2014-06-12 2017-09-29 Shionogi & Co Dérivé de macrolide de polyène
JP7240811B2 (ja) * 2015-04-15 2023-03-16 スファンガ セラピューティクス インコーポレイテッド アムホテリシンｂの誘導体
WO2017100171A1 (en) * 2015-12-08 2017-06-15 Kalyra Pharmaceuticals, Inc. Antifungal compounds and methods
CA3111565A1 (en) 2018-09-07 2020-03-12 The Board Of Trustees Of The University Of Illinois Hybrid amphotericin b derivatives with reduced toxicity

Also Published As

Publication number Publication date
WO2020051465A1 (en) 2020-03-12
AU2019335409B2 (en) 2025-06-05
JP7477177B2 (ja) 2024-05-01
CN113056274A (zh) 2021-06-29
AU2019335409A1 (en) 2021-05-06
EP3846823A4 (en) 2022-04-20
US20200079811A1 (en) 2020-03-12
JP2021536462A (ja) 2021-12-27
KR102893040B1 (ko) 2025-11-27
US11198705B2 (en) 2021-12-14
EP3846823A1 (en) 2021-07-14
KR20210064247A (ko) 2021-06-02

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