CN113056274A - 具有降低的毒性的杂化两性霉素b衍生物 - Google Patents

具有降低的毒性的杂化两性霉素b衍生物 Download PDF

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Publication number
CN113056274A
CN113056274A CN201980072996.8A CN201980072996A CN113056274A CN 113056274 A CN113056274 A CN 113056274A CN 201980072996 A CN201980072996 A CN 201980072996A CN 113056274 A CN113056274 A CN 113056274A
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China
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compound
alkyl
cycloalkyl
heterocyclyl
group
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Pending
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CN201980072996.8A
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English (en)
Chinese (zh)
Inventor
M·D·伯克
J·张
A·罕德尔瓦尔
A·桑塔马里亚
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University of Illinois System
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University of Illinois System
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Publication of CN113056274A publication Critical patent/CN113056274A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN201980072996.8A 2018-09-07 2019-09-06 具有降低的毒性的杂化两性霉素b衍生物 Pending CN113056274A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862728203P 2018-09-07 2018-09-07
US62/728203 2018-09-07
PCT/US2019/049971 WO2020051465A1 (en) 2018-09-07 2019-09-06 Hybrid amphotericin b derivatives with reduced toxicity

Publications (1)

Publication Number Publication Date
CN113056274A true CN113056274A (zh) 2021-06-29

Family

ID=69719049

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980072996.8A Pending CN113056274A (zh) 2018-09-07 2019-09-06 具有降低的毒性的杂化两性霉素b衍生物

Country Status (8)

Country Link
US (1) US11198705B2 (https=)
EP (1) EP3846823A4 (https=)
JP (1) JP7477177B2 (https=)
KR (1) KR102893040B1 (https=)
CN (1) CN113056274A (https=)
AU (1) AU2019335409B2 (https=)
CA (1) CA3111565A1 (https=)
WO (1) WO2020051465A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3111565A1 (en) 2018-09-07 2020-03-12 The Board Of Trustees Of The University Of Illinois Hybrid amphotericin b derivatives with reduced toxicity
KR20220058547A (ko) * 2019-08-08 2022-05-09 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 감소된 독성을 갖는 하이브리드 암포테리신 b 유도체
AU2021325676A1 (en) * 2020-08-10 2023-03-30 The Board Of Trustees Of The University Of Illinois Hybrid amide derivatives of amphotericin B

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105848721A (zh) * 2013-10-07 2016-08-10 伊利诺伊大学评议会 具有提高的治疗指数的两性霉素b衍生物
WO2016168568A1 (en) * 2015-04-15 2016-10-20 Revolution Medicines, Inc. Derivatives of amphotericin b
CN106414473A (zh) * 2014-06-12 2017-02-15 盐野义制药株式会社 多烯大环内酯衍生物
WO2017100171A1 (en) * 2015-12-08 2017-06-15 Kalyra Pharmaceuticals, Inc. Antifungal compounds and methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2749927T3 (es) * 2014-05-16 2020-03-24 Univ Illinois Derivado de anfotericina b con toxicidad reducida
CA3111565A1 (en) 2018-09-07 2020-03-12 The Board Of Trustees Of The University Of Illinois Hybrid amphotericin b derivatives with reduced toxicity

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105848721A (zh) * 2013-10-07 2016-08-10 伊利诺伊大学评议会 具有提高的治疗指数的两性霉素b衍生物
CN106414473A (zh) * 2014-06-12 2017-02-15 盐野义制药株式会社 多烯大环内酯衍生物
WO2016168568A1 (en) * 2015-04-15 2016-10-20 Revolution Medicines, Inc. Derivatives of amphotericin b
WO2017100171A1 (en) * 2015-12-08 2017-06-15 Kalyra Pharmaceuticals, Inc. Antifungal compounds and methods

Also Published As

Publication number Publication date
WO2020051465A1 (en) 2020-03-12
AU2019335409B2 (en) 2025-06-05
JP7477177B2 (ja) 2024-05-01
CA3111565A1 (en) 2020-03-12
AU2019335409A1 (en) 2021-05-06
EP3846823A4 (en) 2022-04-20
US20200079811A1 (en) 2020-03-12
JP2021536462A (ja) 2021-12-27
KR102893040B1 (ko) 2025-11-27
US11198705B2 (en) 2021-12-14
EP3846823A1 (en) 2021-07-14
KR20210064247A (ko) 2021-06-02

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Application publication date: 20210629

RJ01 Rejection of invention patent application after publication