CA3109553A1 - Rnai agents for inhibiting expression of 17beta-hsd type 13 (hsd17b13), compositions thereof, and methods of use - Google Patents

Rnai agents for inhibiting expression of 17beta-hsd type 13 (hsd17b13), compositions thereof, and methods of use Download PDF

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Publication number
CA3109553A1
CA3109553A1 CA3109553A CA3109553A CA3109553A1 CA 3109553 A1 CA3109553 A1 CA 3109553A1 CA 3109553 A CA3109553 A CA 3109553A CA 3109553 A CA3109553 A CA 3109553A CA 3109553 A1 CA3109553 A1 CA 3109553A1
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Prior art keywords
rnai agent
hsd17b13
nucleotides
seq
sense strand
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CA3109553A
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English (en)
French (fr)
Inventor
Zhen Li
Rui ZHU
Shawn A. Morales
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Arrowhead Pharmaceuticals Inc
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Arrowhead Pharmaceuticals Inc
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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CA3109553A 2018-09-19 2019-09-18 Rnai agents for inhibiting expression of 17beta-hsd type 13 (hsd17b13), compositions thereof, and methods of use Pending CA3109553A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862733320P 2018-09-19 2018-09-19
US62/733,320 2018-09-19
US201862773707P 2018-11-30 2018-11-30
US62/773,707 2018-11-30
US201962890220P 2019-08-22 2019-08-22
US62/890,220 2019-08-22
PCT/US2019/051707 WO2020061177A1 (en) 2018-09-19 2019-09-18 Rnai agents for inhibiting expression of 17beta-hsd type 13- (hsd17b13), compositions thereof, and methods of use

Publications (1)

Publication Number Publication Date
CA3109553A1 true CA3109553A1 (en) 2020-03-26

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CA3109553A Pending CA3109553A1 (en) 2018-09-19 2019-09-18 Rnai agents for inhibiting expression of 17beta-hsd type 13 (hsd17b13), compositions thereof, and methods of use

Country Status (21)

Country Link
US (1) US12534728B2 (enExample)
EP (1) EP3852769A4 (enExample)
JP (3) JP7488254B2 (enExample)
KR (1) KR102769565B1 (enExample)
CN (2) CN122235140A (enExample)
AU (1) AU2019342117B9 (enExample)
BR (1) BR112021005137A2 (enExample)
CA (1) CA3109553A1 (enExample)
CL (1) CL2021000669A1 (enExample)
CO (1) CO2021003446A2 (enExample)
CR (1) CR20210186A (enExample)
EC (1) ECSP21027262A (enExample)
IL (1) IL281597B1 (enExample)
MX (1) MX2021003077A (enExample)
MY (1) MY209138A (enExample)
PE (1) PE20211212A1 (enExample)
PH (1) PH12021550423A1 (enExample)
SG (1) SG11202101698WA (enExample)
TW (1) TWI870358B (enExample)
UY (1) UY38382A (enExample)
WO (1) WO2020061177A1 (enExample)

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TW202340466A (zh) * 2021-12-16 2023-10-16 大陸商上海拓界生物醫藥科技有限公司 一種ｄｓｒｎａ、其製備方法及應用
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IL315794A (en) * 2022-04-28 2024-11-01 Enanta Pharm Inc Pyrimidine containing 17-beta-hydrosteroid dehydrogenase type 13 inhibitors
WO2023208109A1 (zh) * 2022-04-29 2023-11-02 北京福元医药股份有限公司 用于抑制HSD17B13表达的siRNA、其缀合物和药物组合物及其用途
TW202400791A (zh) * 2022-05-06 2024-01-01 大陸商蘇州瑞博生物技術股份有限公司 一種核酸、含有該核酸的組合物與綴合物及製備方法和用途
CN120457205A (zh) * 2022-12-22 2025-08-08 上海舶望制药有限公司 抑制17β-羟基类固醇脱氢酶13型(HSD17B13)表达的组合物和方法
WO2024255748A1 (zh) * 2023-06-16 2024-12-19 施能康医药科技(苏州)有限公司 靶向17-β-羟基类固醇脱氢酶13的核酸及其用途
AU2024331015A1 (en) * 2023-08-30 2026-02-26 Arrowhead Pharmaceuticals, Inc. Rnai agents for inhibiting expression of inhibin subunit beta e (inhbe), pharmaceutical compositions thereof, and methods of use
WO2025076225A1 (en) * 2023-10-04 2025-04-10 Enanta Pharmaceuticals, Inc. 17-beta-hydroxysteroid dehydrogenase type 13 inhibitors and methods of use thereof
WO2025074157A1 (en) 2023-10-06 2025-04-10 Glaxosmithkline Intellectual Property (No.3) Limited Treatment of a non-alcoholic fatty liver disease
WO2026057015A1 (zh) * 2024-09-14 2026-03-19 深圳信立泰药业股份有限公司 用于抑制17β-HSD13基因表达的RNAi剂及其制备方法和用途
WO2026082165A1 (zh) * 2024-10-18 2026-04-23 正大天晴药业集团股份有限公司 修饰的双链核糖核酸
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