CA3109392A1 - In vitro detection of nucleic acid - Google Patents

In vitro detection of nucleic acid Download PDF

Info

Publication number
CA3109392A1
CA3109392A1 CA3109392A CA3109392A CA3109392A1 CA 3109392 A1 CA3109392 A1 CA 3109392A1 CA 3109392 A CA3109392 A CA 3109392A CA 3109392 A CA3109392 A CA 3109392A CA 3109392 A1 CA3109392 A1 CA 3109392A1
Authority
CA
Canada
Prior art keywords
nucleic acid
sensor system
hybridization region
hybridization
coding sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3109392A
Other languages
English (en)
French (fr)
Inventor
William Jeremy Blake
Carl W. BROWN III
Frederic VIGNEAULT
James J. Collins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Harvard University
Original Assignee
Massachusetts Institute of Technology
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology, Harvard University filed Critical Massachusetts Institute of Technology
Publication of CA3109392A1 publication Critical patent/CA3109392A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2527/00—Reactions demanding special reaction conditions
    • C12Q2527/101—Temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CA3109392A 2018-08-14 2019-08-14 In vitro detection of nucleic acid Pending CA3109392A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862718427P 2018-08-14 2018-08-14
US62/718,427 2018-08-14
PCT/US2019/046497 WO2020037038A1 (en) 2018-08-14 2019-08-14 In vitro detection of nucleic acid

Publications (1)

Publication Number Publication Date
CA3109392A1 true CA3109392A1 (en) 2020-02-20

Family

ID=69525831

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3109392A Pending CA3109392A1 (en) 2018-08-14 2019-08-14 In vitro detection of nucleic acid

Country Status (12)

Country Link
US (1) US12644148B2 (enExample)
EP (1) EP3837362A4 (enExample)
JP (1) JP2021533771A (enExample)
KR (1) KR20210043605A (enExample)
CN (1) CN112840022A (enExample)
AU (1) AU2019321447A1 (enExample)
BR (1) BR112021002609A2 (enExample)
CA (1) CA3109392A1 (enExample)
IL (1) IL280603A (enExample)
MX (1) MX2021001685A (enExample)
SG (1) SG11202101405RA (enExample)
WO (1) WO2020037038A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4200438A1 (en) * 2020-08-18 2023-06-28 Sherlock Biosciences, Inc. Hybridisation-based sensor systems and probes
WO2022046979A1 (en) * 2020-08-26 2022-03-03 Arizona Board Of Regents On Behalf Of Arizona State University Rapid and low-cost nucleic acid detection using translation-based sequence verification assays
WO2023283622A1 (en) 2021-07-08 2023-01-12 Montana State University Crispr-based programmable rna editing
US11814689B2 (en) 2021-07-21 2023-11-14 Montana State University Nucleic acid detection using type III CRISPR complex
KR102818567B1 (ko) * 2022-05-31 2025-06-11 충남대학교 산학협력단 타겟 핵산 검출용 조성물 및 이의 용도
EP4547865A1 (en) 2022-07-01 2025-05-07 Sherlock Biosciences, Inc. Ambient temperature nucleic acid amplification and detection
CN117330755B (zh) * 2023-08-25 2024-03-26 广东省农业科学院农业生物基因研究中心 一种基于酶催化生物荧光定量检测dna-蛋白质相互作用的方法
KR20250074706A (ko) * 2023-11-15 2025-05-28 대한민국(방위사업청장) 무세포 단백질 합성과 재귀반사신호에 기반한 표적물질 검출방법
KR20250085854A (ko) * 2023-12-04 2025-06-13 충남대학교산학협력단 타겟 핵산 검출용 조성물 및 이의 용도
WO2026015653A2 (en) 2024-07-09 2026-01-15 Sherlock Biosciences, Inc. Power-free fluidic device
WO2026104594A1 (en) * 2024-11-15 2026-05-21 Eth Zurich Biosensor

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8148065B1 (en) 1988-04-06 2012-04-03 City Of Hope Ligation amplification of nucleic acid sequences
US5194370A (en) 1990-05-16 1993-03-16 Life Technologies, Inc. Promoter ligation activated transcription amplification of nucleic acid sequences
US6197508B1 (en) 1990-09-12 2001-03-06 Affymetrix, Inc. Electrochemical denaturation and annealing of nucleic acid
AU6027794A (en) 1993-01-15 1994-08-15 Public Health Research Institute Of The City Of New York, Inc., The Diagnostic assays and kits for rna using rna binary probes and an rna-directed rna ligase
EP0682716A4 (en) 1993-01-15 1999-10-27 New York Health Res Inst RNA ASSAYS USING BINARY RNA PROBES AND A RIBOZYME-LIGASE.
US6593086B2 (en) 1996-05-20 2003-07-15 Mount Sinai School Of Medicine Of New York University Nucleic acid amplification methods
DE69528670T2 (de) 1994-12-23 2004-03-11 Dade Behring Inc., Deerfield Nachweis von nukleinsäuren durch nuklease-katalysierte produktbildung
US5854033A (en) * 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
WO1999024621A2 (en) 1997-11-12 1999-05-20 Cygene, Inc. Methods and compositions for detection of specific nucleotide sequences
WO2000004193A1 (en) 1998-07-20 2000-01-27 Yale University Method for detecting nucleic acids using target-mediated ligation of bipartite primers
US6911307B1 (en) * 1998-12-08 2005-06-28 Proteus S.A. Method of detection in vitro of a target substance in a sample comprising the labelling of said substance with a reporter gene and with the sequences necessary for the expression of said reporter gene in vitro
EP1130113A1 (en) 2000-02-15 2001-09-05 Johannes Petrus Schouten Multiplex ligation dependent amplification assay
US20030008295A1 (en) 2000-03-06 2003-01-09 Nassim Usman Nucleic acid sensor molecules
WO2001066721A2 (en) 2000-03-06 2001-09-13 Ribozyme Pharmaceuticals, Inc. Nucleic acid sensor molecules
US20030065155A1 (en) 2000-03-06 2003-04-03 Nassim Usman Nucleic acid sensor molecules
US6982143B1 (en) 2000-06-20 2006-01-03 The Regents Of The University Of California Normalizing and amplifying RNA
US7164992B1 (en) 2001-03-22 2007-01-16 Blue Heron Biotechnology, Inc. Method and system for polynucleotide synthesis
US20040171047A1 (en) * 2002-05-22 2004-09-02 Dahl Gary A. Target-dependent transcription
US20040086892A1 (en) 2002-11-06 2004-05-06 Crothers Donald M. Universal tag assay
US7932025B2 (en) 2002-12-10 2011-04-26 Massachusetts Institute Of Technology Methods for high fidelity production of long nucleic acid molecules with error control
WO2005030983A2 (en) 2003-09-26 2005-04-07 Circleamp, Inc. Amplification of polynucleotides by rolling circle amplification
US8986614B2 (en) * 2010-02-23 2015-03-24 Rheonix, Inc. Self-contained biological assay apparatus, methods, and applications
US20060211000A1 (en) 2005-03-21 2006-09-21 Sorge Joseph A Methods, compositions, and kits for detection of microRNA
DK1907571T3 (en) 2005-06-15 2017-08-21 Complete Genomics Inc NUCLEIC ACID ANALYSIS USING INCIDENTAL MIXTURES OF NON-OVERLAPPING FRAGMENTS
US8114587B2 (en) 2005-06-23 2012-02-14 Ambergen, Inc. Methods for the detection of colorectal cancer
US20070087417A1 (en) 2005-10-14 2007-04-19 Eugeni Namsaraev Multiplex polynucleotide synthesis
DK1991698T3 (en) 2006-03-01 2014-03-10 Keygene Nv "High-throughput" -sekvensbaseret detection of SNPs using ligeringsassays
US9359635B2 (en) * 2006-04-03 2016-06-07 Promega Corporation Permuted and nonpermuted luciferase biosensors
US20080090238A1 (en) 2006-10-12 2008-04-17 Dan-Hui Dorothy Yang Increased sensitivity of proximity ligation assays
US20080194416A1 (en) 2007-02-08 2008-08-14 Sigma Aldrich Detection of mature small rna molecules
US8034569B2 (en) 2008-06-06 2011-10-11 Biotex, Inc. Methods for molecular detection
CA3094983A1 (en) * 2008-08-15 2010-02-18 Cascade Biosystems, Inc. Methods using enzymatic amplification cascades for detecting target nucleic acid in a sample
AU2010213510B2 (en) 2009-02-16 2014-05-01 Epicentre Technologies Corporation Template-independent ligation of single-stranded DNA
US20110003301A1 (en) 2009-05-08 2011-01-06 Life Technologies Corporation Methods for detecting genetic variations in dna samples
EP2405000A1 (en) 2010-07-06 2012-01-11 Alacris Theranostics GmbH Synthesis of chemical libraries
KR102146721B1 (ko) 2012-07-13 2020-08-21 엑스-켐, 인크. 폴리머라제에 의해 판독가능하지 않은 코딩 올리고뉴클레오티드 연결을 갖는 dna-코딩된 라이브러리
JP6130923B2 (ja) 2012-11-06 2017-05-17 プレジデント アンド フェローズ オブ ハーバード カレッジ リボレギュレーター組成物および使用方法
US10597650B2 (en) 2012-12-21 2020-03-24 New England Biolabs, Inc. Ligase activity
HUE058149T2 (hu) 2014-01-31 2022-07-28 Swift Biosciences Inc Javított eljárások DNS-szubsztrátok feldolgozására
US9758780B2 (en) 2014-06-02 2017-09-12 Drexel University Whole genome mapping by DNA sequencing with linked-paired-end library
US10041109B2 (en) 2015-04-17 2018-08-07 TotemID Inc. Method for detection of a nucleic acid target sequence
WO2017019481A1 (en) 2015-07-24 2017-02-02 The Johns Hopkins University Compositions and methods of rna analysis
US10077459B2 (en) * 2016-05-04 2018-09-18 General Electric Company Cell-free protein expression using rolling circle amplification product
PT3464628T (pt) 2016-06-06 2024-06-03 Redvault Biosciences Lp Construções repórter de alvo e suas utilizações

Also Published As

Publication number Publication date
AU2019321447A1 (en) 2021-02-25
CN112840022A (zh) 2021-05-25
IL280603A (en) 2021-03-25
JP2021533771A (ja) 2021-12-09
KR20210043605A (ko) 2021-04-21
MX2021001685A (es) 2021-05-27
EP3837362A1 (en) 2021-06-23
WO2020037038A1 (en) 2020-02-20
US20210164025A1 (en) 2021-06-03
US12644148B2 (en) 2026-06-02
BR112021002609A2 (pt) 2021-05-11
SG11202101405RA (en) 2021-03-30
EP3837362A4 (en) 2022-05-11

Similar Documents

Publication Publication Date Title
US20210164025A1 (en) In vitro detection of nucleic acid
US20240344051A1 (en) Compositions and methods for ordered and continuous complementary DNA (cDNA) synthesis across non-continuous templates
JP2023518217A5 (enExample)
AU2025205173A1 (en) Sample preparation method and system
US20240368567A1 (en) Recombinant reverse transcriptase variants for improved performance
EP4355866A1 (en) Reverse transcriptase variants for improved performance
CN112204154A (zh) Dna-孔隙-聚合酶复合物的酶促富集
US20120135472A1 (en) Hot-start pcr based on the protein trans-splicing of nanoarchaeum equitans dna polymerase
JP2023546284A (ja) ポイントオブニード診断のための等温核酸増幅方法
CN117693582A (zh) 用于提高性能的逆转录酶变体
Yang et al. Using loop-mediated isothermal DNA amplification (LAMP) and spectral surface plasmon resonance (SPR) to detect methicillin-resistance S. aureus (MRSA)
WO2022040269A1 (en) Hybridisation-based sensor systems and probes
GB2549799A (en) A multiplex assay for the sensitive and specific detection and differentiation of Clostridium difficile
EP3985128A1 (en) Isothermal nucleic acid amplification methods for point-of-need diagnosis of emerging infectious diseases
WO2023222657A1 (en) Method and adaptors
EP4381094B1 (en) Argonaute-based nucleic acid detection system
CA2590399A1 (en) Methods and compositions for detecting bacillus anthracis
US20080311571A1 (en) Nucleic Acid Fragments for Detecting Nucleic Acid and Method for Detecting Nucleic Acid
EP4689159A1 (en) Method and kits
WO2025015041A1 (en) Rna-only, positive control target for clinical diagnostic testing
CN121752587A (zh) 用于等温扩增的新型蛋白质
JP2007135499A (ja) サルモネラｏ９群の検出法

Legal Events

Date Code Title Description
D11 Substantive examination requested

Free format text: ST27 STATUS EVENT CODE: A-1-1-D10-D11-D117 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: REQUEST FOR EXAMINATION RECEIVED

Effective date: 20240807

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P11-P101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT RECEIVED - VOLUNTARY AMENDMENT

Effective date: 20240807

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 5TH ANNIV.) - STANDARD

Year of fee payment: 5

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20240809

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20240809

Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20240809

D00 Search and/or examination requested or commenced

Free format text: ST27 STATUS EVENT CODE: A-1-1-D10-D00-D120 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: VOLUNTARY SUBMISSION OF PRIOR ART RECEIVED

Effective date: 20241212

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20250207

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20250228

D00 Search and/or examination requested or commenced

Free format text: ST27 STATUS EVENT CODE: A-1-1-D10-D00-D123 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: PRIOR ART DISCLOSURE DETERMINED COMPLIANT

Effective date: 20250303

Free format text: ST27 STATUS EVENT CODE: A-1-1-D10-D00-D118 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: REQUEST FOR EXAMINATION REQUIREMENTS DETERMINED COMPLIANT

Effective date: 20250303

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P11-P102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT DETERMINED COMPLIANT

Effective date: 20250303

P13 Application amended

Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P13-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION AMENDED

Effective date: 20250303

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20250303

Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20250303

D11 Substantive examination requested

Free format text: ST27 STATUS EVENT CODE: A-1-2-D10-D11-D155 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: ALL REQUIREMENTS FOR EXAMINATION DETERMINED COMPLIANT

Effective date: 20250429

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20250508

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 6TH ANNIV.) - STANDARD

Year of fee payment: 6

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250808

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250808