CA3107566A1 - A cocrystal of 2-[(1r,6r)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol - Google Patents
A cocrystal of 2-[(1r,6r)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol Download PDFInfo
- Publication number
- CA3107566A1 CA3107566A1 CA3107566A CA3107566A CA3107566A1 CA 3107566 A1 CA3107566 A1 CA 3107566A1 CA 3107566 A CA3107566 A CA 3107566A CA 3107566 A CA3107566 A CA 3107566A CA 3107566 A1 CA3107566 A1 CA 3107566A1
- Authority
- CA
- Canada
- Prior art keywords
- cocrystal
- cbd
- methylcyclohex
- diol
- theta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
- C07C39/17—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings containing other rings in addition to the six-membered aromatic rings, e.g. cyclohexylphenol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/68—Purification; separation; Use of additives, e.g. for stabilisation
- C07C37/70—Purification; separation; Use of additives, e.g. for stabilisation by physical treatment
- C07C37/84—Purification; separation; Use of additives, e.g. for stabilisation by physical treatment by crystallisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Crystallography & Structural Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17382555 | 2017-08-07 | ||
| EP17382555.5 | 2017-08-07 | ||
| PCT/EP2018/071238 WO2019030158A1 (en) | 2017-08-07 | 2018-08-06 | CO-CRYSTAL OF 2 - [(1R, 6R) -6-ISOPROPENYL-3-METHYLCYCLOHEX-2-EN-1-YL] -5-PENTYLBENZENE-1,3-DIOL |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3107566A1 true CA3107566A1 (en) | 2019-02-14 |
Family
ID=59677166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3107566A Pending CA3107566A1 (en) | 2017-08-07 | 2018-08-06 | A cocrystal of 2-[(1r,6r)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11168047B2 (enExample) |
| EP (1) | EP3665145A1 (enExample) |
| JP (1) | JP7186460B2 (enExample) |
| CN (1) | CN111183127B (enExample) |
| CA (1) | CA3107566A1 (enExample) |
| WO (1) | WO2019030158A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190177258A1 (en) * | 2017-12-11 | 2019-06-13 | Artelo Biosciences, Inc. | New solid forms of cannabidiol and uses thereof |
| WO2021138610A1 (en) * | 2020-01-03 | 2021-07-08 | Purisys Llc | Cocrystals of cannabinoids |
| CA3179478A1 (en) * | 2020-05-19 | 2021-11-25 | Joanne Holland | Tetrahydrocannabinolic acid cocrystals |
| CN111792982B (zh) * | 2020-07-10 | 2024-05-14 | 云南农业大学 | 一种易于溶解的块状cbd晶型i及其制备方法 |
| CN113004126B (zh) * | 2021-03-05 | 2022-03-22 | 中国科学院上海药物研究所 | 羟基酪醇甜菜碱共晶,其制备方法及组合物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2393182B (en) | 2002-09-23 | 2007-03-14 | Gw Pharma Ltd | Method of preparing cannabidiol from plant material |
| JP2007516259A (ja) | 2003-12-09 | 2007-06-21 | メッドクリスタルフォームズ、エルエルシー | 活性剤との混合相共結晶の調製方法 |
| TWI366460B (en) | 2005-06-16 | 2012-06-21 | Euro Celtique Sa | Cannabinoid active pharmaceutical ingredient for improved dosage forms |
| CN101316832A (zh) | 2005-09-29 | 2008-12-03 | Amr科技公司 | δ-9-四氢大麻酚的生成方法 |
| MX2010001242A (es) | 2007-07-30 | 2010-07-02 | Alltranz Inc | Profarmacos de canabidiol, composiciones que comprenden profarmacos de canabidiol y metodos para utilizar los mismos. |
| EP2123626A1 (en) | 2008-05-21 | 2009-11-25 | Laboratorios del Dr. Esteve S.A. | Co-crystals of duloxetine and co-crystal formers for the treatment of pain |
| AU2009345154A1 (en) | 2009-04-29 | 2011-12-22 | University Of Kentucky Research Foundation | Cannabinoid-containing compositions and methods for their use |
| WO2011049191A1 (ja) | 2009-10-23 | 2011-04-28 | アステラス製薬株式会社 | 経口投与用医薬組成物 |
| WO2012116349A2 (en) | 2011-02-26 | 2012-08-30 | Amplio Pharma, Llc | Novel cocrystals of ezetimibe |
| ES2547354T3 (es) | 2013-09-03 | 2015-10-05 | Symrise Ag | Mezclas de compuestos cannabinoides, su preparación y uso |
| US10226442B2 (en) * | 2017-07-10 | 2019-03-12 | Syneurx International (Taiwan) Corp. | Lithium salts of N-substituted glycine compounds and uses thereof |
| US20190177258A1 (en) | 2017-12-11 | 2019-06-13 | Artelo Biosciences, Inc. | New solid forms of cannabidiol and uses thereof |
-
2018
- 2018-08-06 CA CA3107566A patent/CA3107566A1/en active Pending
- 2018-08-06 JP JP2020506341A patent/JP7186460B2/ja active Active
- 2018-08-06 EP EP18749373.9A patent/EP3665145A1/en not_active Withdrawn
- 2018-08-06 US US16/636,888 patent/US11168047B2/en active Active
- 2018-08-06 CN CN201880053149.2A patent/CN111183127B/zh active Active
- 2018-08-06 WO PCT/EP2018/071238 patent/WO2019030158A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019030158A1 (en) | 2019-02-14 |
| CN111183127B (zh) | 2023-02-21 |
| US20200369586A1 (en) | 2020-11-26 |
| US11168047B2 (en) | 2021-11-09 |
| JP7186460B2 (ja) | 2022-12-09 |
| JP2020529450A (ja) | 2020-10-08 |
| EP3665145A1 (en) | 2020-06-17 |
| CN111183127A (zh) | 2020-05-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11168047B2 (en) | Cocrystal of 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-5-pentylbenzene-l,3-diol | |
| CN113905730B (zh) | 大麻素共晶体的固体组合物 | |
| EP2743261B1 (en) | Preparation method of crystal form i of the racemate of 4-hydroxy-2-oxo-1-pyrrolidine-acetamide | |
| JP7623936B2 (ja) | 修飾されたカンナビノイドプロファイルを有するカンナビジオール組成物 | |
| CN113336705B (zh) | 一种大麻二酚-2-咪唑-1-甲酸酯及其应用 | |
| US10414718B2 (en) | Dezocine analogue | |
| CN104254537B (zh) | 用于治疗性功能障碍的Phragmalin柠檬苦素类化合物 | |
| EP3337485B1 (en) | Crystalline forms of ibrutinib | |
| US11384040B2 (en) | Methods of synthesizing cannabigergol, cannabigerolic acid, and analogs thereof | |
| AU2010303822A1 (en) | Novel TRPA1 antagonists | |
| EP3027634A1 (en) | Process for preparation of tulathromycin | |
| US11566000B2 (en) | Crystalline form of sofpironium bromide and preparation method thereof | |
| JP2022542143A (ja) | 合成カンナビノールおよびその相同体を調製する方法 | |
| ES2748924B2 (es) | Metodo para la purificacion de alopregnanolona | |
| US20230381134A1 (en) | Cocrystals of cannabinoids | |
| CN110627599B (zh) | 氘代丁基苯酞类化合物及其用途 | |
| EP3442956B1 (en) | A process for the preparation of pyrvinium pamoate and crystalline forms thereof | |
| KR20030076600A (ko) | 새로운 에스트로전 수용체 리간드 및 그 제조 방법ⅰ | |
| CN105143162B (zh) | 合成方法 | |
| Yogesh et al. | Synthesis and antibacterial properties of newer (2-butyl-5-amino-3-benzofuranyl)-4-methoxy phenyl methanone amino acids | |
| HK40068368B (zh) | 索吡溴铵的晶型及其制备方法 | |
| US20190071438A1 (en) | 1, 4, 8-Triazaphenanthrene Derivatives For The Treatment Of Neurodegenerative Disorders |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20230724 |