CA3095724C - Gut-selective sequestering agents for the treatment and prevention of autism and related disorders - Google Patents

Gut-selective sequestering agents for the treatment and prevention of autism and related disorders Download PDF

Info

Publication number
CA3095724C
CA3095724C CA3095724A CA3095724A CA3095724C CA 3095724 C CA3095724 C CA 3095724C CA 3095724 A CA3095724 A CA 3095724A CA 3095724 A CA3095724 A CA 3095724A CA 3095724 C CA3095724 C CA 3095724C
Authority
CA
Canada
Prior art keywords
sequestrant
subject
composition
metabolite
behaviors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3095724A
Other languages
English (en)
French (fr)
Other versions
CA3095724A1 (en
Inventor
Anthony Stewart Campbell
David H. Donabedian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Axial Therapeutics Inc
Original Assignee
Axial Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axial Therapeutics Inc filed Critical Axial Therapeutics Inc
Priority to CA3191747A priority Critical patent/CA3191747A1/en
Publication of CA3095724A1 publication Critical patent/CA3095724A1/en
Application granted granted Critical
Publication of CA3095724C publication Critical patent/CA3095724C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/44—Elemental carbon, e.g. charcoal, carbon black
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/717—Celluloses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA3095724A 2017-03-31 2018-03-31 Gut-selective sequestering agents for the treatment and prevention of autism and related disorders Active CA3095724C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3191747A CA3191747A1 (en) 2017-03-31 2018-03-31 Gut-selective sequestering agents for the treatment and prevention of autism and related disorders

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762480039P 2017-03-31 2017-03-31
US62/480,039 2017-03-31
PCT/US2018/025607 WO2018183986A1 (en) 2017-03-31 2018-03-31 Gut-selective sequestering agents for the treatment and prevention of autism and related disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3191747A Division CA3191747A1 (en) 2017-03-31 2018-03-31 Gut-selective sequestering agents for the treatment and prevention of autism and related disorders

Publications (2)

Publication Number Publication Date
CA3095724A1 CA3095724A1 (en) 2018-10-04
CA3095724C true CA3095724C (en) 2023-04-18

Family

ID=63677186

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3095724A Active CA3095724C (en) 2017-03-31 2018-03-31 Gut-selective sequestering agents for the treatment and prevention of autism and related disorders
CA3191747A Pending CA3191747A1 (en) 2017-03-31 2018-03-31 Gut-selective sequestering agents for the treatment and prevention of autism and related disorders

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3191747A Pending CA3191747A1 (en) 2017-03-31 2018-03-31 Gut-selective sequestering agents for the treatment and prevention of autism and related disorders

Country Status (9)

Country Link
US (4) US10617718B2 (https=)
EP (1) EP3600349A4 (https=)
JP (1) JP6978122B2 (https=)
KR (1) KR102328323B1 (https=)
CN (2) CN114569633B (https=)
AU (3) AU2018243836B9 (https=)
BR (1) BR112019020289A2 (https=)
CA (2) CA3095724C (https=)
WO (1) WO2018183986A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6978122B2 (ja) 2017-03-31 2021-12-08 アキシャル セラピューティクス，インク． 自閉症および関連障害の治療および予防のための腸管選択的隔離剤
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
WO2021011481A1 (en) * 2019-07-12 2021-01-21 The General Hospital Corporation Anti-inflammatory factors
CN114829629A (zh) * 2019-12-19 2022-07-29 希尔氏宠物营养品公司 治疗和降低患上与犬科动物的升高的4-乙基苯基硫酸盐相关的病状的风险的组合物和方法以及鉴定有风险患上此类病状的犬科动物的方法
US20240197795A1 (en) * 2020-07-27 2024-06-20 Boadie DUNLOP Assessment and treatment of depression, anxiety, or related disorders
CN113440522B (zh) * 2021-07-29 2022-12-13 中山大学附属第七医院(深圳) 一种吲哚丙酸在制备用于治疗自闭症药物中的应用
CN115825314A (zh) * 2021-09-17 2023-03-21 中国科学院深圳先进技术研究院 一种阿尔兹海默症生物标志物s-甲基-5′-硫代腺苷及其应用
WO2023154547A1 (en) 2022-02-14 2023-08-17 Axial Therapeutics, Inc. Colon targeted drug delivery
WO2023154966A1 (en) * 2022-02-14 2023-08-17 Axial Therapeutics, Inc. Compositions and methods for sequestering metabolites in the gastrointestinal tract
CN116990395A (zh) * 2022-04-26 2023-11-03 中国科学院深圳先进技术研究院 一种基于粪便的阿尔兹海默症生物标志物及其应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4761284A (en) * 1977-12-27 1988-08-02 Kureha Kagaku Kogy Kabushiki Kaisha Antidote including activated carbon particles
JPS5673542A (en) 1979-11-22 1981-06-18 Kureha Chem Ind Co Ltd Adsorbent
GB9611437D0 (en) 1995-08-03 1996-08-07 Secr Defence Biomaterial
US7651974B2 (en) 2002-11-01 2010-01-26 Kureha Chemical Industry Co., Ltd. Adsorbent for oral administration
CN101084206A (zh) * 2004-12-13 2007-12-05 艾尼纳制药公司 作为5ht2c受体调节剂以治疗与其相关病症的n－联芳基和n－芳基杂芳基2－经取代哌嗪衍生物
WO2010102218A1 (en) * 2009-03-05 2010-09-10 Mithridion, Inc. Compounds and compositions for cognition-enhancement, methods of making, and methods of treating
CN103491949B (zh) * 2011-03-04 2017-02-08 株式会社吴羽 片剂型的口服给药用组合物及其制造方法
WO2012161921A1 (en) * 2011-05-23 2012-11-29 Thomas Jefferson University Intestinal hyperpermeability and prevention of systemic disease
GB201204696D0 (en) * 2012-03-16 2012-05-02 Ucl Business Plc Therapy
WO2014036182A2 (en) 2012-08-29 2014-03-06 California Institute Of Technology Diagnosis and treatment of autism spectrum disorder
TWI520751B (zh) 2013-02-22 2016-02-11 吳羽股份有限公司 經口投予用吸附劑及腎疾病治療劑及肝疾病治療劑
US10060932B2 (en) 2013-07-09 2018-08-28 Stemina Biomarker Discovery, Inc. Biomarkers of autism spectrum disorder
JP2016525138A (ja) * 2013-07-23 2016-08-22 ユーロ−セルティーク エス．エイ． 疼痛および腸内ディスバイオシスをもたらす疾患および／または腸内細菌移行に対するリスクを高める疾患に罹患している患者における痛みの治療への使用のためのオキシコドンおよびナロキソンの組み合わせ
US9763903B2 (en) * 2013-10-22 2017-09-19 Steven Hoffman Compositions and methods for treating intestinal hyperpermeability
US20150111878A1 (en) * 2013-10-22 2015-04-23 Steven Hoffman Compositions and methods for treating intestinal hyperpermeability
US20170020999A1 (en) * 2014-04-04 2017-01-26 Biotechnobel Sa Composition for prevention and/or treatment of chronic inflammation and concomitant biofilms in the gastrointestinal tract
JP6978122B2 (ja) 2017-03-31 2021-12-08 アキシャル セラピューティクス，インク． 自閉症および関連障害の治療および予防のための腸管選択的隔離剤

Also Published As

Publication number Publication date
AU2018243836B2 (en) 2021-04-22
AU2018243836B9 (en) 2021-05-13
EP3600349A1 (en) 2020-02-05
CN114569633B (zh) 2023-11-17
US20180303876A1 (en) 2018-10-25
AU2018243836A1 (en) 2019-11-21
CN110944650A (zh) 2020-03-31
KR20200024133A (ko) 2020-03-06
US11007219B2 (en) 2021-05-18
CA3095724A1 (en) 2018-10-04
US20200368276A1 (en) 2020-11-26
JP6978122B2 (ja) 2021-12-08
EP3600349A4 (en) 2020-09-30
BR112019020289A2 (pt) 2020-09-01
KR102328323B1 (ko) 2021-11-19
US20230364135A1 (en) 2023-11-16
CN114569633A (zh) 2022-06-03
JP2020513032A (ja) 2020-04-30
AU2021206871A1 (en) 2021-08-12
AU2021206871B2 (en) 2021-10-14
NZ758692A (en) 2022-03-25
CN110944650B (zh) 2022-03-04
AU2022200220A1 (en) 2022-02-10
US10617718B2 (en) 2020-04-14
US20200390809A1 (en) 2020-12-17
CA3191747A1 (en) 2018-10-04
WO2018183986A1 (en) 2018-10-04

Similar Documents

Publication Publication Date Title
AU2021206871B2 (en) Gut-selective sequestering agents for the treatment and prevention of autism and related disorders
JP2022088641A (ja) 細菌株を含む組成物
Zhang et al. Research progress of microbiota-gut-brain axis in Parkinson's disease
JP2020520911A (ja) 細菌株を含む組成物
Hu et al. Encapsulated lactiplantibacillus plantarum improves Alzheimer’s symptoms in APP/PS1 mice
Nápoles-Medina et al. Oral administration of Lactobacillus inhibits the permeability of blood‐brain and gut barriers in a parkinsonism model
JP2020520928A (ja) 細菌株を含む組成物
EP2945626B1 (en) Use of alpha 7 nicotinic receptor agonists for the treatment of narcolepsy
WO2016053142A1 (ru) Композиция для детоксикации организма
KR20220034816A (ko) 박테리아 균주를 포함하는 조성물
Shi et al. Production, Mechanisms, and Therapeutic Strategies of Tryptophan Metabolites in CNS Diseases
NZ785988A (en) Gut-selective sequestering agents for the treatment and prevention of autism and
NZ758692B2 (en) Gut-selective sequestering agents for the treatment and prevention of autism and related disorders
HK40075263A (en) Gut-selective sequestering agents for the treatment and prevention of autism and related disorders
WO2023154966A1 (en) Compositions and methods for sequestering metabolites in the gastrointestinal tract
Wang et al. Alternate-day fasting ameliorates α-synuclein pathology and suppresses inflammation via the gut-brain axis in an MPTP-induced subacute mouse model of Parkinson’s disease
KR20220119055A (ko) 박테리아 균주를 포함하는 조성물
He et al. W2006 Beneficial Effects of Fermented Milk Containing Lactobacillus GG and L. Gasseri Tmc0356 On Regulating Intestinal Microflora and Immune Responses for Patients with Allergic Disease
NZ785569A (en) Compositions comprising bacterial strains

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20210329

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-4-4-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20250922

H13 Ip right lapsed

Free format text: ST27 STATUS EVENT CODE: N-4-6-H10-H13-H100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE AND LATE FEE NOT PAID BY DEADLINE OF NOTICE

Effective date: 20260105

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: N-6-6-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20260205