CA3091688A1 - Expression of foxp3 in edited cd34+ cells - Google Patents

Expression of foxp3 in edited cd34+ cells Download PDF

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Publication number
CA3091688A1
CA3091688A1 CA3091688A CA3091688A CA3091688A1 CA 3091688 A1 CA3091688 A1 CA 3091688A1 CA 3091688 A CA3091688 A CA 3091688A CA 3091688 A CA3091688 A CA 3091688A CA 3091688 A1 CA3091688 A1 CA 3091688A1
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Prior art keywords
sequence
cell
foxp3
nucleic acid
seq
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CA3091688A
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English (en)
French (fr)
Inventor
David J. Rawlings
Iram F. KHAN
Yuchi Chiang HONAKER
Swati SINGH
Karen SOMMER
Andrew M. Scharenberg
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Seattle Childrens Hospital
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Seattle Childrens Hospital
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Publication of CA3091688A1 publication Critical patent/CA3091688A1/en
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    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90Stable introduction of foreign DNA into chromosome
    • C12N15/902Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4703Inhibitors; Suppressors
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    • C07K14/4713Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • C12N5/0637Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
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    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0645Macrophages, e.g. Kuepfer cells in the liver; Monocytes
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    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
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    • C12N2800/00Nucleic acids vectors
    • C12N2800/80Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites

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  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3091688A 2018-04-27 2019-04-25 Expression of foxp3 in edited cd34+ cells Pending CA3091688A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862663545P 2018-04-27 2018-04-27
US62/663,545 2018-04-27
PCT/US2019/029082 WO2019210042A1 (en) 2018-04-27 2019-04-25 Expression of foxp3 in edited cd34+ cells

Publications (1)

Publication Number Publication Date
CA3091688A1 true CA3091688A1 (en) 2019-10-31

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CA3091688A Pending CA3091688A1 (en) 2018-04-27 2019-04-25 Expression of foxp3 in edited cd34+ cells

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US (2) US11713459B2 (enExample)
EP (1) EP3784690A4 (enExample)
JP (2) JP7575950B2 (enExample)
CN (1) CN112218882A (enExample)
AU (2) AU2019261438B2 (enExample)
CA (1) CA3091688A1 (enExample)
IL (1) IL277039A (enExample)
SG (1) SG11202007878UA (enExample)
WO (1) WO2019210042A1 (enExample)

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US20210253652A1 (en) * 2018-04-27 2021-08-19 Seattle Children's Hospital (dba Seattle Children's Research Institute) Expression of human foxp3 in gene edited t cells
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Publication number Publication date
EP3784690A1 (en) 2021-03-03
EP3784690A4 (en) 2022-01-19
SG11202007878UA (en) 2020-09-29
CN112218882A (zh) 2021-01-12
JP7575950B2 (ja) 2024-10-31
JP2025013884A (ja) 2025-01-28
AU2019261438A1 (en) 2020-09-10
AU2024266824A1 (en) 2024-12-12
JP2021521856A (ja) 2021-08-30
US20240117352A1 (en) 2024-04-11
IL277039A (en) 2020-10-29
US20210054376A1 (en) 2021-02-25
AU2019261438B2 (en) 2024-08-22
US11713459B2 (en) 2023-08-01
WO2019210042A1 (en) 2019-10-31

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