CA3083852A1 - Biphasic calcium phosphate/hydroxyapatite bone substitute material - Google Patents

Biphasic calcium phosphate/hydroxyapatite bone substitute material Download PDF

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Publication number
CA3083852A1
CA3083852A1 CA3083852A CA3083852A CA3083852A1 CA 3083852 A1 CA3083852 A1 CA 3083852A1 CA 3083852 A CA3083852 A CA 3083852A CA 3083852 A CA3083852 A CA 3083852A CA 3083852 A1 CA3083852 A1 CA 3083852A1
Authority
CA
Canada
Prior art keywords
hap
cap
hydroxyapatite
bone substitute
nanocrystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3083852A
Other languages
English (en)
French (fr)
Inventor
Claudio ZIHLMANN
Michael Bufler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Geistlich Pharma AG
Original Assignee
Geistlich Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geistlich Pharma AG filed Critical Geistlich Pharma AG
Publication of CA3083852A1 publication Critical patent/CA3083852A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0052—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with an inorganic matrix
    • A61L24/0063—Phosphorus containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/32—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Dispersion Chemistry (AREA)
  • Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Manufacturing & Machinery (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
CA3083852A 2017-12-14 2018-12-13 Biphasic calcium phosphate/hydroxyapatite bone substitute material Pending CA3083852A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17207235.7 2017-12-14
EP17207235 2017-12-14
PCT/EP2018/084783 WO2019115704A1 (en) 2017-12-14 2018-12-13 Bone substitute material

Publications (1)

Publication Number Publication Date
CA3083852A1 true CA3083852A1 (en) 2019-06-20

Family

ID=60781527

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3083852A Pending CA3083852A1 (en) 2017-12-14 2018-12-13 Biphasic calcium phosphate/hydroxyapatite bone substitute material

Country Status (18)

Country Link
US (2) US11351287B2 (cg-RX-API-DMAC10.html)
EP (1) EP3544643B1 (cg-RX-API-DMAC10.html)
JP (2) JP6880330B2 (cg-RX-API-DMAC10.html)
KR (1) KR102233325B1 (cg-RX-API-DMAC10.html)
CN (1) CN111465418B (cg-RX-API-DMAC10.html)
AU (1) AU2018382557B2 (cg-RX-API-DMAC10.html)
BR (1) BR112020010213B1 (cg-RX-API-DMAC10.html)
CA (1) CA3083852A1 (cg-RX-API-DMAC10.html)
DK (1) DK3544643T3 (cg-RX-API-DMAC10.html)
ES (1) ES2803976T3 (cg-RX-API-DMAC10.html)
HU (1) HUE050062T2 (cg-RX-API-DMAC10.html)
IL (1) IL275203B2 (cg-RX-API-DMAC10.html)
MX (1) MX2020005846A (cg-RX-API-DMAC10.html)
PL (1) PL3544643T3 (cg-RX-API-DMAC10.html)
PT (1) PT3544643T (cg-RX-API-DMAC10.html)
SG (1) SG11202004726YA (cg-RX-API-DMAC10.html)
TW (1) TWI852918B (cg-RX-API-DMAC10.html)
WO (1) WO2019115704A1 (cg-RX-API-DMAC10.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3083852A1 (en) 2017-12-14 2019-06-20 Geistlich Pharma Ag Biphasic calcium phosphate/hydroxyapatite bone substitute material
CN114761048B (zh) 2019-06-14 2023-05-02 盖斯特里希医药公司 骨替代材料的胶原基质或颗粒共混物
US12539350B2 (en) 2020-05-25 2026-02-03 Dhawan Shrey Ion-substituted bovine hydroxyapatite for bone regeneration
DE202021004032U1 (de) 2020-08-29 2022-10-10 BioScientific Designs d.o.o Ein steriles Medizinprodukt als Knochenersatz, Zubereitung und Verwendung

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JPS60220056A (ja) * 1984-04-18 1985-11-02 三菱マテリアル株式会社 人工歯
US4865602A (en) 1986-11-06 1989-09-12 Collagen Corporation Gamma irradiation of collagen/mineral mixtures
DE3711426A1 (de) 1987-04-04 1988-10-13 Mtu Muenchen Gmbh Implantat mit bioaktivem ueberzug
GB8813033D0 (en) 1988-06-02 1988-07-06 Geistlich Soehne Ag Chemical compound
JPH07504106A (ja) 1992-02-28 1995-05-11 コラーゲン　コーポレイション 注射可能なセラミック組成物及びそれらの製造及び使用のための方法
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IT1288038B1 (it) 1996-04-30 1998-09-10 Flametal S P A Procedimento per la preparazione di rivestimenti di idrossiapatite
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US20070026030A1 (en) 2005-07-27 2007-02-01 Berkeley Advanced Biomaterials, Inc. Method of preparing rheological materials for bone and cartilage repair
ES2729425T3 (es) * 2006-10-24 2019-11-04 Biomet 3I Llc Deposición de nanopartículas discretas sobre una superficie nanoestructurada de un implante
CN1974876B (zh) * 2006-11-02 2010-07-07 华南理工大学 钛金属表面生物活性膜层及其喷砂-微弧氧化复合工艺
CN102497891B (zh) 2009-06-23 2015-05-27 盖斯特里希医药公司 骨替代材料
US20130045360A1 (en) 2010-01-29 2013-02-21 Georgia Tech Research Corporation Surface modification of implant devices
CN101850131A (zh) * 2010-04-30 2010-10-06 武汉理工大学 晶核引导骨性结合的金属植入体表面改性的方法
US9107983B2 (en) 2010-10-27 2015-08-18 Warsaw Orthopedic, Inc. Osteoconductive matrices comprising statins
WO2012084214A1 (en) 2010-12-22 2012-06-28 Geistlich Pharma Ag Bone substitute material
DE102011050183A1 (de) * 2011-05-06 2012-11-08 Aesculap Ag Oberflächenprofilierter Gitterkörper
GB201122405D0 (en) * 2011-12-23 2012-02-08 Univ Aberdeen Calcium phosphate material
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JP6813716B1 (ja) 2017-12-14 2021-01-13 ガイストリッヒ ファーマ アーゲー 骨代替材料
WO2019115795A1 (en) 2017-12-14 2019-06-20 Geistlich Pharma Ag Dried implant composition and injectable aqueous implant formulation
CA3083852A1 (en) 2017-12-14 2019-06-20 Geistlich Pharma Ag Biphasic calcium phosphate/hydroxyapatite bone substitute material

Also Published As

Publication number Publication date
US20190184059A1 (en) 2019-06-20
RU2020118930A3 (cg-RX-API-DMAC10.html) 2022-02-25
US20200016293A1 (en) 2020-01-16
EP3544643A1 (en) 2019-10-02
TWI852918B (zh) 2024-08-21
KR102233325B1 (ko) 2021-03-29
CN111465418A (zh) 2020-07-28
IL275203B2 (en) 2023-03-01
US10646615B2 (en) 2020-05-12
SG11202004726YA (en) 2020-07-29
WO2019115704A1 (en) 2019-06-20
PT3544643T (pt) 2020-07-27
PL3544643T3 (pl) 2020-12-28
US11351287B2 (en) 2022-06-07
CN111465418B (zh) 2021-07-09
IL275203A (en) 2020-07-30
BR112020010213A2 (pt) 2020-08-18
KR20200076753A (ko) 2020-06-29
ES2803976T3 (es) 2021-02-01
IL275203B (en) 2022-11-01
JP2021506401A (ja) 2021-02-22
BR112020010213B1 (pt) 2020-12-22
JP2021118906A (ja) 2021-08-12
RU2020118930A (ru) 2022-01-14
EP3544643B1 (en) 2020-05-13
JP7249376B2 (ja) 2023-03-30
DK3544643T3 (da) 2020-07-06
HUE050062T2 (hu) 2020-11-30
AU2018382557B2 (en) 2024-05-02
JP6880330B2 (ja) 2021-06-02
AU2018382557A1 (en) 2020-06-11
MX2020005846A (es) 2020-09-07
TW201936216A (zh) 2019-09-16

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