CA3077804C - Peptides and methods of using same - Google Patents
Peptides and methods of using same Download PDFInfo
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- CA3077804C CA3077804C CA3077804A CA3077804A CA3077804C CA 3077804 C CA3077804 C CA 3077804C CA 3077804 A CA3077804 A CA 3077804A CA 3077804 A CA3077804 A CA 3077804A CA 3077804 C CA3077804 C CA 3077804C
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8125—Alpha-1-antitrypsin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Biochemistry (AREA)
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- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261584517P | 2012-01-09 | 2012-01-09 | |
| US61/584,517 | 2012-01-09 | ||
| US201261699571P | 2012-09-11 | 2012-09-11 | |
| US61/699,571 | 2012-09-11 | ||
| CA2859777A CA2859777C (en) | 2012-01-09 | 2013-01-07 | Serine protease inhibitor (serpin) peptides and methods thereof |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2859777A Division CA2859777C (en) | 2012-01-09 | 2013-01-07 | Serine protease inhibitor (serpin) peptides and methods thereof |
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| CA3077804A1 CA3077804A1 (en) | 2013-07-18 |
| CA3077804C true CA3077804C (en) | 2023-07-25 |
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| CA2859777A Active CA2859777C (en) | 2012-01-09 | 2013-01-07 | Serine protease inhibitor (serpin) peptides and methods thereof |
| CA3077804A Active CA3077804C (en) | 2012-01-09 | 2013-01-07 | Peptides and methods of using same |
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| Application Number | Title | Priority Date | Filing Date |
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| CA2859777A Active CA2859777C (en) | 2012-01-09 | 2013-01-07 | Serine protease inhibitor (serpin) peptides and methods thereof |
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| Country | Link |
|---|---|
| US (6) | US9951104B2 (OSRAM) |
| EP (2) | EP3381461B1 (OSRAM) |
| JP (1) | JP6416627B2 (OSRAM) |
| AU (3) | AU2013208293B2 (OSRAM) |
| CA (2) | CA2859777C (OSRAM) |
| DK (2) | DK3381461T3 (OSRAM) |
| ES (2) | ES2871544T3 (OSRAM) |
| IL (1) | IL233481A0 (OSRAM) |
| MX (1) | MX365403B (OSRAM) |
| WO (1) | WO2013106273A2 (OSRAM) |
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| DK3381461T3 (da) | 2012-01-09 | 2021-05-17 | Serpin Pharma Llc | Peptider og fremgangsmåder til anvendelse deraf |
| WO2014197524A2 (en) * | 2013-06-06 | 2014-12-11 | Serpin Pharma, Llc | Peptide therapy for treatment of alpha-1 antitrypsin deficiency and associated pathologies |
| US20160194365A1 (en) | 2013-07-08 | 2016-07-07 | The University Of Utah Research Foundation | Methods for treatment of and prophylaxis against inflammatory disorders |
| CA2961375A1 (en) * | 2014-09-16 | 2016-03-24 | Bioincept, Llc | Compositions and methods for treating acute radiation syndrome |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| US20160256611A1 (en) * | 2015-03-04 | 2016-09-08 | Microvention, Inc. | Drug Delivery Device |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CA2996975C (en) * | 2015-08-28 | 2022-02-15 | Serpin Pharma, Llc | Methods for treatment of diseases |
| WO2017083433A1 (en) * | 2015-11-09 | 2017-05-18 | Cortexyme, Inc. | Inhibitors of arginine gingipain |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| EP3789491B1 (en) | 2018-05-02 | 2025-04-16 | Kansai Medical University Educational Corporation | Peptide and use therefor |
| WO2022010939A2 (en) * | 2020-07-06 | 2022-01-13 | Serpin Pharma, Llc | Peptides and methods of using the same |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1190891B (it) | 1982-06-24 | 1988-02-24 | Anic Spa | Metodo per la sintesi in fase solida di polipeptidi retroinvertiti |
| US5910304A (en) | 1982-12-13 | 1999-06-08 | Texas A&M University System | Low-dose oral administration of interferons |
| US5049386A (en) | 1985-01-07 | 1991-09-17 | Syntex (U.S.A.) Inc. | N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4946787A (en) | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| CA1320905C (en) | 1986-11-06 | 1993-08-03 | Joseph M. Cummins | Treatment of immuno-resistant disease |
| FI81498C (fi) | 1987-01-13 | 1990-11-12 | Biocon Oy | Kirurgiska material och instrument. |
| US5580561A (en) * | 1987-03-06 | 1996-12-03 | Cercek; Boris | Methods and pharmaceutical compositions for blocking suppression of immune defense mechanisms using an antibody, a factor, or an antisense peptide |
| US5270171A (en) * | 1987-03-06 | 1993-12-14 | Boris Cercek | Cancer-associated SCM-recognition factor, preparation and method of use |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5693622A (en) | 1989-03-21 | 1997-12-02 | Vical Incorporated | Expression of exogenous polynucleotide sequences cardiac muscle of a mammal |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| US5436146A (en) | 1989-09-07 | 1995-07-25 | The Trustees Of Princeton University | Helper-free stocks of recombinant adeno-associated virus vectors |
| US5676954A (en) | 1989-11-03 | 1997-10-14 | Vanderbilt University | Method of in vivo delivery of functioning foreign genes |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| US5981276A (en) | 1990-06-20 | 1999-11-09 | Dana-Farber Cancer Institute | Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof |
| US5353535A (en) | 1990-11-05 | 1994-10-11 | Plumly George W | Floor type advertising apparatus |
| CA2143823C (en) | 1992-08-27 | 2005-07-26 | Alfio Comis | Retro-, inverso - and retro-inverso synthetic peptide analogues |
| EP1132080A3 (en) | 1992-09-10 | 2001-10-17 | Children's Medical Center Corporation | Biodegradable polymer matrices for sustained delivery of local anesthetic agents |
| JPH08503855A (ja) | 1992-12-03 | 1996-04-30 | ジェンザイム・コーポレイション | 嚢胞性線維症に対する遺伝子治療 |
| US5514653A (en) * | 1994-09-09 | 1996-05-07 | Washington University | Method of blocking the SEC receptor |
| US5665557A (en) | 1994-11-14 | 1997-09-09 | Systemix, Inc. | Method of purifying a population of cells enriched for hematopoietic stem cells populations of cells obtained thereby and methods of use thereof |
| CA2234931C (en) | 1995-10-16 | 2010-01-19 | Dana-Farber Cancer Institute | Novel expression vectors and methods of use |
| US6036949A (en) | 1998-03-05 | 2000-03-14 | Amarillo Biosciences, Inc. | Treatment of fibromyalgia with low doses of interferon |
| ES2219011T3 (es) | 1998-04-24 | 2004-11-16 | University Of Florida | Vector viral adeno-asociado recombinante que codifica alfa-1 antitripsina para terapia genica. |
| US20100210528A1 (en) * | 1999-03-05 | 2010-08-19 | Leland Shapiro | Compositions, methods and uses for inhibition and/or treatment of influenza infection |
| US20070003518A1 (en) | 2002-04-19 | 2007-01-04 | Atkinson Mark A | Raav vector-based compositions and methods for the prevention and treatment of mammalian diseases |
| ES2622522T3 (es) | 2003-08-26 | 2017-07-06 | The Regents Of The University Of Colorado, A Body Corporate | Inhibidores de la actividad proteasa de serina y su uso en métodos y composiciones para el tratamiento de infecciones bacterianas |
| JP2007517913A (ja) | 2004-01-13 | 2007-07-05 | バソジェニックス ファーマシューティカルズ， インコーポレイテッド | カルシトニン遺伝子関連ペプチドを投与することによって急性心筋梗塞を処置するための方法およびカルシトニン遺伝子関連ペプチドを含有する組成物 |
| DK1766412T3 (da) * | 2004-05-21 | 2009-05-25 | Inst Systems Biology | Sammensætninger og fremgangsmåder til kvantificering af serumglycoproteiner |
| US8715649B2 (en) | 2005-06-07 | 2014-05-06 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods of use for alpha-1 antitrypsin having no significant serine protease inhibitor activity |
| WO2007070981A1 (en) | 2005-12-23 | 2007-06-28 | Vital Health Sciences Pty Ltd | Compounds having cytokine modulating properties |
| US20110191871A1 (en) | 2006-02-28 | 2011-08-04 | Trustees Of Boston University | Methods to identify factors associated with muscle growth and uses thereof |
| US20080008694A1 (en) | 2006-07-05 | 2008-01-10 | Elgebaly Salwa A | Methods to prevent and treat diseases |
| US20090203602A1 (en) * | 2006-09-01 | 2009-08-13 | Cohava Gelber | Compositions and methods for diagnosis and treatment of type 2 diabetes |
| US7951776B2 (en) | 2006-09-01 | 2011-05-31 | American Type Culture Collection | Methods for treatment of type 1 diabetes |
| US20100267052A1 (en) | 2006-09-01 | 2010-10-21 | American Type Culture Collection | Compositions and methods for diagnosis and treatment of type 2 diabetes |
| WO2008033890A2 (en) | 2006-09-12 | 2008-03-20 | Beth Israel Deaconess Medical Center, Inc. | Compositions containing alpha-1-antitrypsin and methods for use |
| EA201000399A1 (ru) | 2007-08-30 | 2011-02-28 | Кьюрдм, Инк. | Композиции и способы использования проостровковых пептидов и их аналогов |
| WO2009046015A2 (en) | 2007-09-30 | 2009-04-09 | University Of Florida Research Foundation, Inc. | Combination therapies for treating type 1 diabetes |
| US7923253B2 (en) * | 2007-11-05 | 2011-04-12 | Battelle Memorial Institute | Method for identifying type I diabetes mellitus in humans |
| US9522179B2 (en) | 2010-03-04 | 2016-12-20 | Virginia Commonwealth University | Compositions and methods for modulating cardiac conditions |
| WO2011126882A2 (en) * | 2010-03-30 | 2011-10-13 | American Type Culture Collection | Therapeutic peptides and their derivatives and therapeutic uses thereof |
| WO2011139368A2 (en) | 2010-05-06 | 2011-11-10 | The Feinstein Institute For Medical Research | Methods of treatment of inflammatory diseases |
| DK3381461T3 (da) | 2012-01-09 | 2021-05-17 | Serpin Pharma Llc | Peptider og fremgangsmåder til anvendelse deraf |
| WO2013106589A1 (en) | 2012-01-10 | 2013-07-18 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
| WO2014197524A2 (en) | 2013-06-06 | 2014-12-11 | Serpin Pharma, Llc | Peptide therapy for treatment of alpha-1 antitrypsin deficiency and associated pathologies |
| KR20160146242A (ko) | 2015-06-12 | 2016-12-21 | 현대자동차주식회사 | 터보차저 엔진의 재순환 밸브 구동 장치 및 방법 |
| CA2996975C (en) | 2015-08-28 | 2022-02-15 | Serpin Pharma, Llc | Methods for treatment of diseases |
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