CA3077694A1 - Methods and compositions for inhibiting adam10 biological activities - Google Patents
Methods and compositions for inhibiting adam10 biological activities Download PDFInfo
- Publication number
- CA3077694A1 CA3077694A1 CA3077694A CA3077694A CA3077694A1 CA 3077694 A1 CA3077694 A1 CA 3077694A1 CA 3077694 A CA3077694 A CA 3077694A CA 3077694 A CA3077694 A CA 3077694A CA 3077694 A1 CA3077694 A1 CA 3077694A1
- Authority
- CA
- Canada
- Prior art keywords
- amino acid
- seq
- adam10
- modulating peptide
- positions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24081—ADAM10 endopeptidase (3.4.24.81)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762566580P | 2017-10-02 | 2017-10-02 | |
| US62/566,580 | 2017-10-02 | ||
| US201762589842P | 2017-11-22 | 2017-11-22 | |
| US62/589,842 | 2017-11-22 | ||
| PCT/US2018/053938 WO2019070685A1 (en) | 2017-10-02 | 2018-10-02 | METHODS AND COMPOSITIONS FOR INHIBITING BIOLOGICAL ACTIVITIES OF ADAM10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3077694A1 true CA3077694A1 (en) | 2019-04-11 |
Family
ID=65995419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3077694A Pending CA3077694A1 (en) | 2017-10-02 | 2018-10-02 | Methods and compositions for inhibiting adam10 biological activities |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20190345473A1 (https=) |
| EP (1) | EP3691671A4 (https=) |
| JP (2) | JP7448219B2 (https=) |
| AU (1) | AU2018345601B2 (https=) |
| CA (1) | CA3077694A1 (https=) |
| IL (1) | IL273725A (https=) |
| MX (1) | MX2020004218A (https=) |
| WO (1) | WO2019070685A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021512596A (ja) | 2018-01-31 | 2021-05-20 | ヴェラ セラピューティクス エルエルシー | Ａｄａｍ９生物活性を阻害するための方法および組成物 |
| WO2020227714A1 (en) * | 2019-05-09 | 2020-11-12 | Verra Therapeutics, Llc | Methods and compositions for inhibiting adam8 biological activities |
| US20250177333A1 (en) * | 2022-03-08 | 2025-06-05 | Nova Southeastern University | Method for treating rheumatoid arthritis (ra) using an enzyme-and substrate selective exosite inhibitor of a disintegrin and metalloprotease 10 (adam10) |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003270625A1 (en) | 2002-09-11 | 2004-04-30 | Justus-Liebig-Universität Giessen | Inhibition or activation of adam9 and adam15 for treatment of vascularization-related disease and wound healing |
| ATE549028T1 (de) * | 2003-05-15 | 2012-03-15 | Tufts College | Stabile analoga von glp-1 |
| WO2006084075A2 (en) | 2005-02-02 | 2006-08-10 | Raven Biotechnologies, Inc. | Adam-9 modulators |
| JP2008535854A (ja) | 2005-04-07 | 2008-09-04 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド | 癌の診断、検出および処置におけるａｄａｍ１０ |
| US7638301B2 (en) * | 2006-08-28 | 2009-12-29 | Biozyme, Inc. | Prodomain modulators of ADAM 10 |
| US20090285840A1 (en) | 2008-04-29 | 2009-11-19 | New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Methods for treating pathological neovascularization |
| US20090285640A1 (en) | 2008-05-16 | 2009-11-19 | Hilfiker William K | Method for constructing a mechanically stabilized earthen embankment using semi-extensible steel soil reinforcements |
| EP2637679A4 (en) * | 2010-11-09 | 2015-09-23 | Univ Chicago | ROLE OF ADAM10 AND ITS RELEVANCE TO DISEASES AND THERAPEUTICS |
| WO2012088105A2 (en) * | 2010-12-20 | 2012-06-28 | Biozyme Inc. | Methods and compositions for predicting disease status in cancer |
| WO2015117199A1 (en) | 2014-02-04 | 2015-08-13 | Monash University | Anti-metalloprotease antibody for diagnosis and treatment of cancers |
-
2018
- 2018-10-02 AU AU2018345601A patent/AU2018345601B2/en active Active
- 2018-10-02 JP JP2020520057A patent/JP7448219B2/ja active Active
- 2018-10-02 MX MX2020004218A patent/MX2020004218A/es unknown
- 2018-10-02 EP EP18865159.0A patent/EP3691671A4/en active Pending
- 2018-10-02 US US16/149,764 patent/US20190345473A1/en not_active Abandoned
- 2018-10-02 WO PCT/US2018/053938 patent/WO2019070685A1/en not_active Ceased
- 2018-10-02 CA CA3077694A patent/CA3077694A1/en active Pending
-
2020
- 2020-03-31 IL IL273725A patent/IL273725A/en unknown
-
2022
- 2022-05-19 US US17/748,163 patent/US12297469B2/en active Active
-
2023
- 2023-11-01 JP JP2023187803A patent/JP2024012470A/ja active Pending
-
2025
- 2025-03-06 US US19/072,106 patent/US20250207119A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20190345473A1 (en) | 2019-11-14 |
| IL273725A (en) | 2020-05-31 |
| US20230203468A1 (en) | 2023-06-29 |
| EP3691671A4 (en) | 2022-01-19 |
| US12297469B2 (en) | 2025-05-13 |
| WO2019070685A1 (en) | 2019-04-11 |
| MX2020004218A (es) | 2020-11-11 |
| EP3691671A1 (en) | 2020-08-12 |
| US20250207119A1 (en) | 2025-06-26 |
| AU2018345601A1 (en) | 2020-05-21 |
| JP7448219B2 (ja) | 2024-03-12 |
| JP2021500321A (ja) | 2021-01-07 |
| JP2024012470A (ja) | 2024-01-30 |
| AU2018345601B2 (en) | 2025-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20220907 |
|
| MFA | Maintenance fee for application paid |
Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 6TH ANNIV.) - STANDARD Year of fee payment: 6 |
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| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20240911 |
|
| U11 | Full renewal or maintenance fee paid |
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| D15 | Examination report completed |
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| U00 | Fee paid |
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