AU2018345601B2 - Methods and compositions for inhibiting ADAM10 biological activities - Google Patents

Methods and compositions for inhibiting ADAM10 biological activities Download PDF

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Publication number
AU2018345601B2
AU2018345601B2 AU2018345601A AU2018345601A AU2018345601B2 AU 2018345601 B2 AU2018345601 B2 AU 2018345601B2 AU 2018345601 A AU2018345601 A AU 2018345601A AU 2018345601 A AU2018345601 A AU 2018345601A AU 2018345601 B2 AU2018345601 B2 AU 2018345601B2
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Australia
Prior art keywords
adam10
inhibiting
compositions
methods
biological activities
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AU2018345601A
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English (en)
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AU2018345601A1 (en
Inventor
Marcia L. Moss
Chris Prince
Robert Rasmussen
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Verra Therapeutics LLC
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Verra Therapeutics LLC
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Assigned to Verra Therapeutics LLC reassignment Verra Therapeutics LLC Amend patent request/document other than specification (104) Assignors: VERRA THERAPEUTICS
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24081—ADAM10 endopeptidase (3.4.24.81)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2018345601A 2017-10-02 2018-10-02 Methods and compositions for inhibiting ADAM10 biological activities Active AU2018345601B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762566580P 2017-10-02 2017-10-02
US62/566,580 2017-10-02
US201762589842P 2017-11-22 2017-11-22
US62/589,842 2017-11-22
PCT/US2018/053938 WO2019070685A1 (en) 2017-10-02 2018-10-02 METHODS AND COMPOSITIONS FOR INHIBITING BIOLOGICAL ACTIVITIES OF ADAM10

Publications (2)

Publication Number Publication Date
AU2018345601A1 AU2018345601A1 (en) 2020-05-21
AU2018345601B2 true AU2018345601B2 (en) 2025-05-15

Family

ID=65995419

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018345601A Active AU2018345601B2 (en) 2017-10-02 2018-10-02 Methods and compositions for inhibiting ADAM10 biological activities

Country Status (8)

Country Link
US (3) US20190345473A1 (https=)
EP (1) EP3691671A4 (https=)
JP (2) JP7448219B2 (https=)
AU (1) AU2018345601B2 (https=)
CA (1) CA3077694A1 (https=)
IL (1) IL273725A (https=)
MX (1) MX2020004218A (https=)
WO (1) WO2019070685A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021512596A (ja) 2018-01-31 2021-05-20 ヴェラ セラピューティクス エルエルシー Ａｄａｍ９生物活性を阻害するための方法および組成物
WO2020227714A1 (en) * 2019-05-09 2020-11-12 Verra Therapeutics, Llc Methods and compositions for inhibiting adam8 biological activities
US20250177333A1 (en) * 2022-03-08 2025-06-05 Nova Southeastern University Method for treating rheumatoid arthritis (ra) using an enzyme-and substrate selective exosite inhibitor of a disintegrin and metalloprotease 10 (adam10)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080096820A1 (en) * 2006-08-28 2008-04-24 Biozyme, Inc. Prodomain modulators of ADAM 10

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003270625A1 (en) 2002-09-11 2004-04-30 Justus-Liebig-Universität Giessen Inhibition or activation of adam9 and adam15 for treatment of vascularization-related disease and wound healing
ATE549028T1 (de) * 2003-05-15 2012-03-15 Tufts College Stabile analoga von glp-1
WO2006084075A2 (en) 2005-02-02 2006-08-10 Raven Biotechnologies, Inc. Adam-9 modulators
JP2008535854A (ja) 2005-04-07 2008-09-04 ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド 癌の診断、検出および処置におけるａｄａｍ１０
US20090285840A1 (en) 2008-04-29 2009-11-19 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Methods for treating pathological neovascularization
US20090285640A1 (en) 2008-05-16 2009-11-19 Hilfiker William K Method for constructing a mechanically stabilized earthen embankment using semi-extensible steel soil reinforcements
EP2637679A4 (en) * 2010-11-09 2015-09-23 Univ Chicago ROLE OF ADAM10 AND ITS RELEVANCE TO DISEASES AND THERAPEUTICS
WO2012088105A2 (en) * 2010-12-20 2012-06-28 Biozyme Inc. Methods and compositions for predicting disease status in cancer
WO2015117199A1 (en) 2014-02-04 2015-08-13 Monash University Anti-metalloprotease antibody for diagnosis and treatment of cancers

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080096820A1 (en) * 2006-08-28 2008-04-24 Biozyme, Inc. Prodomain modulators of ADAM 10

Also Published As

Publication number Publication date
US20190345473A1 (en) 2019-11-14
CA3077694A1 (en) 2019-04-11
IL273725A (en) 2020-05-31
US20230203468A1 (en) 2023-06-29
EP3691671A4 (en) 2022-01-19
US12297469B2 (en) 2025-05-13
WO2019070685A1 (en) 2019-04-11
MX2020004218A (es) 2020-11-11
EP3691671A1 (en) 2020-08-12
US20250207119A1 (en) 2025-06-26
AU2018345601A1 (en) 2020-05-21
JP7448219B2 (ja) 2024-03-12
JP2021500321A (ja) 2021-01-07
JP2024012470A (ja) 2024-01-30

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