CA3076330A1 - Encapsulation of gastric residence systems - Google Patents
Encapsulation of gastric residence systems Download PDFInfo
- Publication number
- CA3076330A1 CA3076330A1 CA3076330A CA3076330A CA3076330A1 CA 3076330 A1 CA3076330 A1 CA 3076330A1 CA 3076330 A CA3076330 A CA 3076330A CA 3076330 A CA3076330 A CA 3076330A CA 3076330 A1 CA3076330 A1 CA 3076330A1
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- Prior art keywords
- gastric residence
- residence system
- compactable
- gastric
- newtons
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- IQSHMXAZFHORGY-UHFFFAOYSA-N methyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound COC(=O)C=C.CC(=C)C(O)=O IQSHMXAZFHORGY-UHFFFAOYSA-N 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229940111688 monobasic potassium phosphate Drugs 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- DNKKLDKIFMDAPT-UHFFFAOYSA-N n,n-dimethylmethanamine;2-methylprop-2-enoic acid Chemical compound CN(C)C.CC(=C)C(O)=O.CC(=C)C(O)=O DNKKLDKIFMDAPT-UHFFFAOYSA-N 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229940065472 octyl acrylate Drugs 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229940044476 poloxamer 407 Drugs 0.000 description 1
- 239000005014 poly(hydroxyalkanoate) Substances 0.000 description 1
- 239000005015 poly(hydroxybutyrate) Substances 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229950005134 polycarbophil Drugs 0.000 description 1
- 229920002643 polyglutamic acid Polymers 0.000 description 1
- 229920000903 polyhydroxyalkanoate Polymers 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920002744 polyvinyl acetate phthalate Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 235000019423 pullulan Nutrition 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000000807 solvent casting Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229920003179 starch-based polymer Polymers 0.000 description 1
- 239000004628 starch-based polymer Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/074—Filling capsules; Related operations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4833—Encapsulating processes; Filling of capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Surgical Instruments (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762561043P | 2017-09-20 | 2017-09-20 | |
| US62/561,043 | 2017-09-20 | ||
| PCT/US2018/051816 WO2019060458A1 (en) | 2017-09-20 | 2018-09-19 | ENCAPSULATION OF GASTRIC SYSTEMS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3076330A1 true CA3076330A1 (en) | 2019-03-28 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3076330A Pending CA3076330A1 (en) | 2017-09-20 | 2018-09-19 | Encapsulation of gastric residence systems |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11793751B2 (de) |
| EP (1) | EP3684321A4 (de) |
| JP (1) | JP7288435B2 (de) |
| CN (1) | CN111511338B (de) |
| AU (2) | AU2018337837B2 (de) |
| CA (1) | CA3076330A1 (de) |
| TW (1) | TWI783044B (de) |
| WO (1) | WO2019060458A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016342374B2 (en) | 2015-10-23 | 2022-08-04 | Lyndra Therapeutics, Inc. | Gastric residence systems for sustained release of therapeutic agents and methods of use thereof |
| US11992552B2 (en) | 2015-12-08 | 2024-05-28 | Lyndra Therapeutics, Inc. | Geometric configurations for gastric residence systems |
| CN110022861B (zh) | 2016-09-30 | 2024-06-28 | 林德拉治疗公司 | 用于金刚烷类药物缓释的胃驻留系统 |
| US12023406B2 (en) | 2017-06-09 | 2024-07-02 | Lyndra Therapeutics, Inc. | Gastric residence systems with release rate-modulating films |
| US11684315B2 (en) * | 2017-11-28 | 2023-06-27 | Massachusetts Institute Of Technology | Gastric resident electronics |
| JP2022525926A (ja) * | 2019-03-20 | 2022-05-20 | リンドラ セラピューティクス， インコーポレイティド | 胃内滞留剤形用のカプセル及びカプセルコーティング |
| JP2022554383A (ja) * | 2019-11-08 | 2022-12-28 | リンドラ セラピューティクス， インコーポレイティド | 胃内滞留システムのための放出速度調節フィルム用製剤 |
| WO2021092491A1 (en) * | 2019-11-08 | 2021-05-14 | Lyndra, Inc. | Gastric residence systems for administration of active agents |
| US20220409528A1 (en) * | 2019-11-08 | 2022-12-29 | Lyndra Therapeutics, Inc. | Gastric residence systems having a filament for improved gastric residence |
| WO2024097572A1 (en) * | 2022-11-01 | 2024-05-10 | Merck Sharp & Dohme Llc | Gastroretentive systems and methods of making and using same |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3044599A (en) * | 1959-08-17 | 1962-07-17 | Arthur Colton Company | Feeding mechanism |
| US4304767A (en) | 1980-05-15 | 1981-12-08 | Sri International | Polymers of di- (and higher functionality) ketene acetals and polyols |
| US4767627A (en) * | 1985-05-29 | 1988-08-30 | Merck & Co., Inc. | Drug delivery device which can be retained in the stomach for a controlled period of time |
| US4758436A (en) | 1985-05-29 | 1988-07-19 | Merck & Co., Inc. | Drug delivery device which can be retained in the stomach for a controlled period of time |
| US5002772A (en) * | 1988-05-31 | 1991-03-26 | Pfizer Inc. | Gastric retention system for controlled drug release |
| JPH03163011A (ja) * | 1989-08-31 | 1991-07-15 | Yamanouchi Pharmaceut Co Ltd | 胃内滞留デバイス |
| US5081822A (en) * | 1990-02-01 | 1992-01-21 | Warner-Lambert Company | Automatic caplet filler |
| AU650113B2 (en) * | 1991-04-05 | 1994-06-09 | Eli Lilly And Company | Sustained release capsule and formulations |
| WO1999007342A1 (en) * | 1997-08-11 | 1999-02-18 | Alza Corporation | Prolonged release active agent dosage form adapted for gastric retention |
| US7669388B2 (en) | 2004-07-30 | 2010-03-02 | Merrion Research Iii Limited | Process and machine for automated manufacture of gastro-retentive devices |
| TR201902010T4 (tr) | 2006-01-18 | 2019-03-21 | Intec Pharma Ltd | Bir ajanın oral alımına yönelik taşıyıcı cihaz. |
| EP2858604B1 (de) * | 2012-06-07 | 2024-02-21 | Epitomee Medical Ltd | Expandierte vorrichtung |
| EP3091962B1 (de) * | 2013-12-05 | 2022-06-08 | Epitomee Medical Ltd. | Rückhaltevorrichtungen und systeme zur in-situ-freisetzung von pharmazeutischen wirkstoffen |
| EP3155024B1 (de) * | 2014-06-11 | 2020-09-16 | Massachusetts Institute Of Technology | Retentive strukturen und zugehörige verfahrenund zugehörige verfahren |
| WO2017093976A1 (en) | 2015-12-02 | 2017-06-08 | Teva Pharmaceutical Industries Ltd. | Device for preparing gastroretentive dosage forms |
| US11992552B2 (en) * | 2015-12-08 | 2024-05-28 | Lyndra Therapeutics, Inc. | Geometric configurations for gastric residence systems |
-
2018
- 2018-09-19 CN CN201880074767.5A patent/CN111511338B/zh active Active
- 2018-09-19 CA CA3076330A patent/CA3076330A1/en active Pending
- 2018-09-19 AU AU2018337837A patent/AU2018337837B2/en active Active
- 2018-09-19 WO PCT/US2018/051816 patent/WO2019060458A1/en unknown
- 2018-09-19 EP EP18858151.6A patent/EP3684321A4/de active Pending
- 2018-09-19 US US16/648,207 patent/US11793751B2/en active Active
- 2018-09-19 JP JP2020516575A patent/JP7288435B2/ja active Active
- 2018-09-20 TW TW107133159A patent/TWI783044B/zh active
-
2023
- 2023-09-19 US US18/470,327 patent/US20240139102A1/en active Pending
-
2024
- 2024-06-05 AU AU2024203792A patent/AU2024203792A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| TW201919558A (zh) | 2019-06-01 |
| AU2024203792A1 (en) | 2024-06-20 |
| CN111511338B (zh) | 2022-11-29 |
| CN111511338A (zh) | 2020-08-07 |
| US11793751B2 (en) | 2023-10-24 |
| EP3684321A4 (de) | 2021-10-06 |
| JP2020534315A (ja) | 2020-11-26 |
| EP3684321A1 (de) | 2020-07-29 |
| JP7288435B2 (ja) | 2023-06-07 |
| AU2018337837B2 (en) | 2024-03-07 |
| AU2018337837A1 (en) | 2020-04-23 |
| US20200281851A1 (en) | 2020-09-10 |
| TWI783044B (zh) | 2022-11-11 |
| US20240139102A1 (en) | 2024-05-02 |
| WO2019060458A1 (en) | 2019-03-28 |
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