CA3076035A1 - Intracoronary characterization of microvascular obstruction (mvo) and myocardial infarction - Google Patents
Intracoronary characterization of microvascular obstruction (mvo) and myocardial infarction Download PDFInfo
- Publication number
- CA3076035A1 CA3076035A1 CA3076035A CA3076035A CA3076035A1 CA 3076035 A1 CA3076035 A1 CA 3076035A1 CA 3076035 A CA3076035 A CA 3076035A CA 3076035 A CA3076035 A CA 3076035A CA 3076035 A1 CA3076035 A1 CA 3076035A1
- Authority
- CA
- Canada
- Prior art keywords
- vessel
- mvo
- pressure
- change
- infusate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000010125 myocardial infarction Diseases 0.000 title claims description 24
- 238000012512 characterization method Methods 0.000 title description 2
- 238000001802 infusion Methods 0.000 claims abstract description 82
- 238000000034 method Methods 0.000 claims abstract description 63
- 230000002792 vascular Effects 0.000 claims abstract description 57
- 238000004364 calculation method Methods 0.000 claims abstract description 17
- 230000004044 response Effects 0.000 claims abstract description 15
- 230000008859 change Effects 0.000 claims description 67
- 238000005259 measurement Methods 0.000 claims description 36
- 210000004369 blood Anatomy 0.000 claims description 30
- 239000008280 blood Substances 0.000 claims description 30
- 210000002216 heart Anatomy 0.000 claims description 25
- 230000007574 infarction Effects 0.000 claims description 20
- 206010061216 Infarction Diseases 0.000 claims description 18
- 230000017531 blood circulation Effects 0.000 claims description 18
- 230000001225 therapeutic effect Effects 0.000 claims description 18
- 238000003745 diagnosis Methods 0.000 claims description 15
- 238000002560 therapeutic procedure Methods 0.000 claims description 14
- 230000036772 blood pressure Effects 0.000 claims description 13
- 238000009530 blood pressure measurement Methods 0.000 claims description 12
- 230000000903 blocking effect Effects 0.000 claims description 11
- 210000000056 organ Anatomy 0.000 claims description 10
- 238000011282 treatment Methods 0.000 claims description 10
- 210000005166 vasculature Anatomy 0.000 claims description 9
- 210000004556 brain Anatomy 0.000 claims description 5
- 208000032064 Chronic Limb-Threatening Ischemia Diseases 0.000 claims description 4
- 206010022657 Intestinal infarction Diseases 0.000 claims description 4
- 206010022680 Intestinal ischaemia Diseases 0.000 claims description 4
- 206010034576 Peripheral ischaemia Diseases 0.000 claims description 4
- 206010038470 Renal infarct Diseases 0.000 claims description 4
- 206010063897 Renal ischaemia Diseases 0.000 claims description 4
- 210000003734 kidney Anatomy 0.000 claims description 4
- 210000004185 liver Anatomy 0.000 claims description 4
- 230000002685 pulmonary effect Effects 0.000 claims description 4
- 206010056328 Hepatic ischaemia Diseases 0.000 claims description 3
- 208000006193 Pulmonary infarction Diseases 0.000 claims description 3
- 230000008901 benefit Effects 0.000 claims description 3
- 206010019680 hepatic infarction Diseases 0.000 claims description 3
- 210000000936 intestine Anatomy 0.000 claims description 3
- 210000004072 lung Anatomy 0.000 claims description 3
- 230000007575 pulmonary infarction Effects 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims description 2
- 102100040243 Microtubule-associated protein tau Human genes 0.000 description 21
- 238000012360 testing method Methods 0.000 description 18
- 230000010410 reperfusion Effects 0.000 description 17
- 108010026424 tau Proteins Proteins 0.000 description 15
- 210000004088 microvessel Anatomy 0.000 description 14
- 210000004165 myocardium Anatomy 0.000 description 13
- 210000004351 coronary vessel Anatomy 0.000 description 11
- 239000003814 drug Substances 0.000 description 11
- 238000002595 magnetic resonance imaging Methods 0.000 description 11
- 208000007536 Thrombosis Diseases 0.000 description 9
- 230000000747 cardiac effect Effects 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 8
- 210000001736 capillary Anatomy 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 230000017074 necrotic cell death Effects 0.000 description 8
- 206010028851 Necrosis Diseases 0.000 description 7
- 210000001367 artery Anatomy 0.000 description 7
- 238000004422 calculation algorithm Methods 0.000 description 7
- 101000891579 Homo sapiens Microtubule-associated protein tau Proteins 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 230000007774 longterm Effects 0.000 description 6
- 230000002107 myocardial effect Effects 0.000 description 6
- 102000009123 Fibrin Human genes 0.000 description 5
- 108010073385 Fibrin Proteins 0.000 description 5
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 5
- 230000001154 acute effect Effects 0.000 description 5
- 210000003414 extremity Anatomy 0.000 description 5
- 229950003499 fibrin Drugs 0.000 description 5
- 238000003384 imaging method Methods 0.000 description 5
- 230000009885 systemic effect Effects 0.000 description 5
- 229910052688 Gadolinium Inorganic materials 0.000 description 4
- 206010019280 Heart failures Diseases 0.000 description 4
- 239000012891 Ringer solution Substances 0.000 description 4
- 230000030833 cell death Effects 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 230000003073 embolic effect Effects 0.000 description 4
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 230000002861 ventricular Effects 0.000 description 4
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 3
- 230000005856 abnormality Effects 0.000 description 3
- 206010000891 acute myocardial infarction Diseases 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000034994 death Effects 0.000 description 3
- 230000007850 degeneration Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000003511 endothelial effect Effects 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 229960002897 heparin Drugs 0.000 description 3
- 229920000669 heparin Polymers 0.000 description 3
- 210000005240 left ventricle Anatomy 0.000 description 3
- 230000015654 memory Effects 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 229940124597 therapeutic agent Drugs 0.000 description 3
- 206010002383 Angina Pectoris Diseases 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 206010063837 Reperfusion injury Diseases 0.000 description 2
- 238000002399 angioplasty Methods 0.000 description 2
- 230000006793 arrhythmia Effects 0.000 description 2
- 206010003119 arrhythmia Diseases 0.000 description 2
- 210000002565 arteriole Anatomy 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000004217 heart function Effects 0.000 description 2
- 230000002962 histologic effect Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 208000028867 ischemia Diseases 0.000 description 2
- 230000003680 myocardial damage Effects 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 206010002329 Aneurysm Diseases 0.000 description 1
- 208000031104 Arterial Occlusive disease Diseases 0.000 description 1
- 206010007513 Cardiac aneurysm Diseases 0.000 description 1
- 206010007559 Cardiac failure congestive Diseases 0.000 description 1
- 208000031229 Cardiomyopathies Diseases 0.000 description 1
- 206010011086 Coronary artery occlusion Diseases 0.000 description 1
- 208000003037 Diastolic Heart Failure Diseases 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000029549 Muscle injury Diseases 0.000 description 1
- 208000000770 Non-ST Elevated Myocardial Infarction Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 208000008253 Systolic Heart Failure Diseases 0.000 description 1
- IYIKLHRQXLHMJQ-UHFFFAOYSA-N amiodarone Chemical compound CCCCC=1OC2=CC=CC=C2C=1C(=O)C1=CC(I)=C(OCCN(CC)CC)C(I)=C1 IYIKLHRQXLHMJQ-UHFFFAOYSA-N 0.000 description 1
- 229960005260 amiodarone Drugs 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 230000004872 arterial blood pressure Effects 0.000 description 1
- 208000021328 arterial occlusion Diseases 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000003683 cardiac damage Effects 0.000 description 1
- 238000013184 cardiac magnetic resonance imaging Methods 0.000 description 1
- 230000007211 cardiovascular event Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 238000011443 conventional therapy Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 229940039227 diagnostic agent Drugs 0.000 description 1
- 230000003205 diastolic effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 210000001174 endocardium Anatomy 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000010247 heart contraction Effects 0.000 description 1
- 230000036732 histological change Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 238000013152 interventional procedure Methods 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 238000007431 microscopic evaluation Methods 0.000 description 1
- 230000010060 microvascular dysfunction Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000008065 myocardial cell damage Effects 0.000 description 1
- 208000037891 myocardial injury Diseases 0.000 description 1
- 210000000107 myocyte Anatomy 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000004789 organ system Anatomy 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 238000013146 percutaneous coronary intervention Methods 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000036262 stenosis Effects 0.000 description 1
- 208000037804 stenosis Diseases 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 230000002537 thrombolytic effect Effects 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- 210000000264 venule Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
- A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
- A61B5/02152—Measuring pressure in heart or blood vessels by means inserted into the body specially adapted for venous pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
- A61B5/026—Measuring blood flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4848—Monitoring or testing the effects of treatment, e.g. of medication
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6852—Catheters
- A61B5/6853—Catheters with a balloon
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
- G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
- G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Physiology (AREA)
- Vascular Medicine (AREA)
- Primary Health Care (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Databases & Information Systems (AREA)
- General Business, Economics & Management (AREA)
- Business, Economics & Management (AREA)
- Data Mining & Analysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Surgical Instruments (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762560545P | 2017-09-19 | 2017-09-19 | |
| US62/560,545 | 2017-09-19 | ||
| PCT/US2018/051760 WO2019060421A1 (en) | 2017-09-19 | 2018-09-19 | INTRACORONARY MICROVASCULAR OBSTRUCTION CHARACTERIZATION (MVO) AND MYOCARDIAL INFARCTION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3076035A1 true CA3076035A1 (en) | 2019-03-28 |
Family
ID=63998740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3076035A Pending CA3076035A1 (en) | 2017-09-19 | 2018-09-19 | Intracoronary characterization of microvascular obstruction (mvo) and myocardial infarction |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11412936B2 (enExample) |
| EP (1) | EP3684247A1 (enExample) |
| JP (1) | JP7249672B2 (enExample) |
| CN (1) | CN111655121B (enExample) |
| AU (1) | AU2018336787B2 (enExample) |
| CA (1) | CA3076035A1 (enExample) |
| WO (1) | WO2019060421A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3010447A1 (en) | 2016-01-04 | 2017-07-13 | Corflow Therapeutics Ag | System and methods for treating mvo |
| US11433183B2 (en) | 2018-03-09 | 2022-09-06 | Corflow Therapeutics Ag | System for diagnosing and treating microvascular obstructions |
| WO2019060421A1 (en) | 2017-09-19 | 2019-03-28 | Jon Helge Hoem | INTRACORONARY MICROVASCULAR OBSTRUCTION CHARACTERIZATION (MVO) AND MYOCARDIAL INFARCTION |
| WO2019232452A1 (en) | 2018-05-31 | 2019-12-05 | Bernard Andre | Microfluidic coronary circulatory model |
| ES2964535T3 (es) | 2018-09-21 | 2024-04-08 | Corflow Therapeutics Ag | Aparato para la evaluación de la disfunción microvascular |
| WO2021035190A1 (en) | 2019-08-21 | 2021-02-25 | Corflow Therapeutics Ag | Controlled-flow infusion catheter and method |
| AU2021274173A1 (en) * | 2020-05-22 | 2022-12-22 | Corflow Therapeutics Ag | Controlled flow infusion microvascular dysfunction diagnostic and therapy |
| AU2022206116A1 (en) * | 2021-01-11 | 2023-07-20 | Corflow Therapeutics Ag | Apparatus and method for determining and/or treating microvascular obstruction |
| WO2025160126A1 (en) * | 2024-01-22 | 2025-07-31 | The Trustees Of Indiana University | Method and system for radiation-free assessment of coronary and skeletal muscle microvascular function using in-situ administration of vasoactive agents |
| CN117976155B (zh) * | 2024-04-01 | 2024-07-26 | 杭州脉流科技有限公司 | 基于造影剂示踪曲线获得冠脉功能学参数的方法、计算机设备 |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4689041A (en) | 1984-01-20 | 1987-08-25 | Eliot Corday | Retrograde delivery of pharmacologic and diagnostic agents via venous circulation |
| US5439446A (en) | 1994-06-30 | 1995-08-08 | Boston Scientific Corporation | Stent and therapeutic delivery system |
| US20050245894A1 (en) | 1996-05-20 | 2005-11-03 | Medtronic Vascular, Inc. | Methods and apparatuses for drug delivery to an intravascular occlusion |
| US20010041862A1 (en) | 1997-09-02 | 2001-11-15 | Morton G. Glickman | Novel apparatus and method of treating a tumor in the extremity of a patient |
| EP0917886B1 (en) | 1997-10-23 | 2003-10-01 | Schneider (Europe) GmbH | Seal for catheter assembly with dilation and occlusion balloon |
| US20040260333A1 (en) | 1997-11-12 | 2004-12-23 | Dubrul William R. | Medical device and method |
| US6295990B1 (en) | 1998-02-03 | 2001-10-02 | Salient Interventional Systems, Inc. | Methods and systems for treating ischemia |
| US6622367B1 (en) | 1998-02-03 | 2003-09-23 | Salient Interventional Systems, Inc. | Intravascular device and method of manufacture and use |
| US6423032B2 (en) | 1998-03-13 | 2002-07-23 | Arteria Medical Science, Inc. | Apparatus and methods for reducing embolization during treatment of carotid artery disease |
| US6488671B1 (en) | 1999-10-22 | 2002-12-03 | Corazon Technologies, Inc. | Methods for enhancing fluid flow through an obstructed vascular site, and systems and kits for use in practicing the same |
| US6485500B1 (en) | 2000-03-21 | 2002-11-26 | Advanced Cardiovascular Systems, Inc. | Emboli protection system |
| US6616597B2 (en) | 2000-12-12 | 2003-09-09 | Datascope Investment Corp. | Intra-aortic balloon catheter having a dual sensor pressure sensing system |
| US7722596B2 (en) | 2004-02-26 | 2010-05-25 | Osprey Medical, Inc. | Regional cardiac tissue treatment |
| US7955371B2 (en) | 2004-05-12 | 2011-06-07 | Medtronic Vascular, Inc. | System and method for stent deployment and infusion of a therapeutic agent into tissue adjacent to the stent ends |
| IES20040803A2 (en) | 2004-12-01 | 2006-06-14 | Medtronic Vascular Connaught | Drug delivery device |
| US7837650B1 (en) | 2004-12-30 | 2010-11-23 | Advanced Cardiovascular Systems, Inc. | Method and apparatus to prevent reperfusion injury |
| WO2007061530A1 (en) | 2005-10-14 | 2007-05-31 | Cytori Therapeutics, Inc. | Cell delivery catheters with distal tip high fidelity sensors |
| WO2008088579A2 (en) | 2006-08-02 | 2008-07-24 | Tricardia, Llc | Microvascular obstruction detection and therapy |
| CN201058169Y (zh) | 2007-05-24 | 2008-05-14 | 席刚明 | 一种同轴球囊溶栓导管 |
| US8216209B2 (en) | 2007-05-31 | 2012-07-10 | Abbott Cardiovascular Systems Inc. | Method and apparatus for delivering an agent to a kidney |
| JP5695907B2 (ja) | 2007-11-19 | 2015-04-08 | マリンクロッド エルエルシー | 圧力監視を用いた開存性チェックを有するパワーインゼクタ |
| JP5147004B2 (ja) | 2008-03-27 | 2013-02-20 | 国立大学法人鳥取大学 | 生体内温熱療法及び閉塞下動注化学療法を併用した新規治療方法に用いるバルーンカテーテル |
| EP3093039A1 (en) | 2008-11-03 | 2016-11-16 | Advanced Catheter Therapies, Inc. | Occlusion perfusion catheter |
| EP2413787B1 (en) | 2009-03-31 | 2017-07-26 | St. Jude Medical Coordination Center BVBA | Sensor guide wire |
| EP2464278B1 (en) * | 2009-08-10 | 2015-09-16 | P2-Science Aps | Utp for the diagnosis of stenoses and other conditions of restricted blood flow |
| US8706209B2 (en) | 2010-02-05 | 2014-04-22 | 3Dt Holdings, Llc | Devices, systems, and methods for measuring parallel tissue conductance, luminal cross-sectional areas, fluid velocity, and/or determining plaque vulnerability using temperature |
| US8708996B2 (en) | 2010-04-30 | 2014-04-29 | Abbott Cardiovascular Systems, Inc. | Methods and device for synergistic mitigation of reperfusion injury after an ischemic event |
| US9155869B2 (en) | 2010-04-30 | 2015-10-13 | Abbott Cardiovascular Systems Inc. | Catheter having inflation and deflation lumen useful for preventing or reducing reperfusion injury |
| US8540669B2 (en) | 2010-04-30 | 2013-09-24 | Abbott Cardiovascular Systems Inc. | Catheter system providing step reduction for postconditioning |
| JP5922111B2 (ja) * | 2010-06-23 | 2016-05-24 | ピーツー−サイエンス・エペイエス | 充血剤注入と同時に血圧測定を行う診断目的の動脈用複合カテーテル |
| US20120157913A1 (en) | 2010-12-16 | 2012-06-21 | Atherolysis Medical, Inc. | Catheter apparatus and method for atherolysis |
| US9533124B2 (en) | 2011-04-14 | 2017-01-03 | Abbott Cardiovascular Systems Inc. | Reperfusion injury devices |
| WO2013019830A2 (en) | 2011-08-01 | 2013-02-07 | Alcyone Lifesciences, Inc. | Microfluidic drug delivery devices |
| US8177704B1 (en) | 2011-12-22 | 2012-05-15 | Miracor Medical Systems Gmbh | System and method for treating heart tissue |
| EP2866872A4 (en) | 2012-06-28 | 2016-07-06 | Volcano Corp | INTRAVASCULAR DEVICES, SYSTEMS AND METHODS |
| US10010673B2 (en) | 2012-08-28 | 2018-07-03 | Osprey Medical, Inc. | Adjustable medium diverter |
| US10022497B2 (en) | 2012-08-28 | 2018-07-17 | Osprey Medical, Inc. | Reservoir for collection and reuse of diverted medium |
| US9320846B2 (en) | 2012-08-28 | 2016-04-26 | Osprey Medical, Inc. | Devices and methods for modulating medium delivery |
| US9999718B2 (en) | 2012-08-28 | 2018-06-19 | Osprey Medical, Inc. | Volume monitoring device utilizing light-based systems |
| US11219719B2 (en) | 2012-08-28 | 2022-01-11 | Osprey Medical, Inc. | Volume monitoring systems |
| US10327695B2 (en) * | 2012-12-21 | 2019-06-25 | Volcano Corporation | Functional gain measurement technique and representation |
| US9844383B2 (en) | 2013-05-08 | 2017-12-19 | Embolx, Inc. | Devices and methods for low pressure tumor embolization |
| HK1219909A1 (zh) | 2013-05-08 | 2017-04-21 | Embolx, Inc. | 使用整合流量调节之用於经由血管之肿瘤栓塞之装置及方法 |
| MX380885B (es) * | 2013-08-14 | 2025-03-12 | Pedra Tech Pte Ltd | Sistemas para valoración de revascularización. |
| CN105848573B (zh) * | 2013-10-25 | 2019-04-16 | 波士顿科学国际有限公司 | 利用光学传感来确定血流量的导管系统和方法 |
| US9877660B2 (en) | 2013-11-14 | 2018-01-30 | Medtronic Vascular Galway | Systems and methods for determining fractional flow reserve without adenosine or other pharmalogical agent |
| JP2016538048A (ja) | 2013-11-15 | 2016-12-08 | アシスト・メディカル・システムズ，インコーポレイテッド | マルチセンサ患部評価装置および方法 |
| US9855049B2 (en) | 2013-12-11 | 2018-01-02 | Miracor Medical Systems Gmbh | System and method for treating heart tissue |
| JP6389526B2 (ja) | 2014-01-14 | 2018-09-12 | ボルケーノ コーポレイション | 血液透析動静脈瘻成熟を評価するシステム及び方法 |
| US8876850B1 (en) | 2014-06-19 | 2014-11-04 | Aria Cv, Inc. | Systems and methods for treating pulmonary hypertension |
| WO2017004432A1 (en) | 2015-07-01 | 2017-01-05 | Fractyl Laboratories, Inc. | Systems, devices and methods for performing medical procedures in the intestine |
| JP2016168151A (ja) | 2015-03-12 | 2016-09-23 | 株式会社東海メディカルプロダクツ | バルーンカテーテル |
| US11433183B2 (en) | 2018-03-09 | 2022-09-06 | Corflow Therapeutics Ag | System for diagnosing and treating microvascular obstructions |
| CA3010447A1 (en) | 2016-01-04 | 2017-07-13 | Corflow Therapeutics Ag | System and methods for treating mvo |
| US9550046B1 (en) | 2016-02-16 | 2017-01-24 | Embolx, Inc. | Balloon catheter and methods of fabrication and use |
| WO2017160270A1 (en) | 2016-03-14 | 2017-09-21 | Sanovas, Inc. | Modulated drug delivery |
| US10492805B2 (en) | 2016-04-06 | 2019-12-03 | Walk Vascular, Llc | Systems and methods for thrombolysis and delivery of an agent |
| EP3592304B1 (en) | 2017-03-20 | 2023-09-13 | Corflow Therapeutics AG | Combined stent reperfusion system |
| WO2019060421A1 (en) | 2017-09-19 | 2019-03-28 | Jon Helge Hoem | INTRACORONARY MICROVASCULAR OBSTRUCTION CHARACTERIZATION (MVO) AND MYOCARDIAL INFARCTION |
| WO2019232452A1 (en) | 2018-05-31 | 2019-12-05 | Bernard Andre | Microfluidic coronary circulatory model |
| ES2964535T3 (es) | 2018-09-21 | 2024-04-08 | Corflow Therapeutics Ag | Aparato para la evaluación de la disfunción microvascular |
| US12115327B2 (en) | 2019-03-05 | 2024-10-15 | Measurement Specialties, Inc. | Sensor device and methods of operation for a catheter based treatment of myocardial microvascular obstruction |
| AU2021274173A1 (en) | 2020-05-22 | 2022-12-22 | Corflow Therapeutics Ag | Controlled flow infusion microvascular dysfunction diagnostic and therapy |
-
2018
- 2018-09-19 WO PCT/US2018/051760 patent/WO2019060421A1/en not_active Ceased
- 2018-09-19 EP EP18793291.8A patent/EP3684247A1/en active Pending
- 2018-09-19 US US16/135,987 patent/US11412936B2/en active Active
- 2018-09-19 JP JP2020537457A patent/JP7249672B2/ja active Active
- 2018-09-19 AU AU2018336787A patent/AU2018336787B2/en active Active
- 2018-09-19 CA CA3076035A patent/CA3076035A1/en active Pending
- 2018-09-19 CN CN201880070198.7A patent/CN111655121B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN111655121B (zh) | 2024-05-24 |
| US11412936B2 (en) | 2022-08-16 |
| WO2019060421A1 (en) | 2019-03-28 |
| US20190082976A1 (en) | 2019-03-21 |
| AU2018336787A1 (en) | 2020-04-23 |
| EP3684247A1 (en) | 2020-07-29 |
| JP2020534132A (ja) | 2020-11-26 |
| CN111655121A (zh) | 2020-09-11 |
| JP7249672B2 (ja) | 2023-03-31 |
| AU2018336787B2 (en) | 2024-05-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2018336787B2 (en) | Intracoronary characterization of microvascular obstruction (MVO) and myocardial infarction | |
| CN113271874B (zh) | 用于评估微血管功能障碍的设备 | |
| US11433183B2 (en) | System for diagnosing and treating microvascular obstructions | |
| JP6921112B2 (ja) | Ｍｖｏを治療するためのシステムおよび方法 | |
| JP7773483B2 (ja) | 患者に関する血管生理学的パラメータを決定するシステムまたは動脈血管を有する患者を診断または処置するためのシステム | |
| EP4274471B1 (en) | Apparatus and method for determining and/or treating microvascular obstruction | |
| US20220378301A1 (en) | Intracoronary characterization of microvascular obstruction (mvo) and myocardial infarction | |
| US20230381415A1 (en) | Method and apparatus for diagnosis and treatment of microvascular dysfunction | |
| Gu et al. | Treatment of right ventricular perforation during percutaneous coronary intervention | |
| Goyal et al. | Cardiac catheterization | |
| Wilson et al. | Catheter-Based Coronary Angiography |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20230821 |
|
| EEER | Examination request |
Effective date: 20230821 |