CA3065481A1 - Additive manufacturing using recombinant collagen-containing formulation - Google Patents

Additive manufacturing using recombinant collagen-containing formulation Download PDF

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Publication number
CA3065481A1
CA3065481A1 CA3065481A CA3065481A CA3065481A1 CA 3065481 A1 CA3065481 A1 CA 3065481A1 CA 3065481 A CA3065481 A CA 3065481A CA 3065481 A CA3065481 A CA 3065481A CA 3065481 A1 CA3065481 A1 CA 3065481A1
Authority
CA
Canada
Prior art keywords
formulation
collagen
curable
featuring
recombinant human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3065481A
Other languages
English (en)
French (fr)
Inventor
Oded Shoseyov
Nadav Orr
Jasmine SEROR MAKNOUZ
Revital ZARKA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Collplant Ltd
Original Assignee
Collplant Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Collplant Ltd filed Critical Collplant Ltd
Publication of CA3065481A1 publication Critical patent/CA3065481A1/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3847—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3852—Cartilage, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/386—Ligaments, tendons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/10—Processes of additive manufacturing
    • B29C64/106—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y70/00—Materials specially adapted for additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Manufacturing & Machinery (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Mechanical Engineering (AREA)
  • Optics & Photonics (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA3065481A 2017-06-09 2018-06-08 Additive manufacturing using recombinant collagen-containing formulation Pending CA3065481A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762517179P 2017-06-09 2017-06-09
US62/517,179 2017-06-09
PCT/IL2018/050627 WO2018225076A1 (en) 2017-06-09 2018-06-08 Additive manufacturing using recombinant collagen-containing formulation

Publications (1)

Publication Number Publication Date
CA3065481A1 true CA3065481A1 (en) 2018-12-13

Family

ID=64566597

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3065481A Pending CA3065481A1 (en) 2017-06-09 2018-06-08 Additive manufacturing using recombinant collagen-containing formulation

Country Status (6)

Country Link
US (2) US12115276B2 (enExample)
EP (1) EP3634512A4 (enExample)
JP (2) JP7339889B2 (enExample)
AU (1) AU2018282131B2 (enExample)
CA (1) CA3065481A1 (enExample)
WO (1) WO2018225076A1 (enExample)

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JP7339889B2 (ja) 2017-06-09 2023-09-06 コルプラント リミテッド 組換えコラーゲン含有配合物を使用した積層造形
KR102955766B1 (ko) 2018-05-03 2026-04-22 콜플랜트 리미티드 진피 충전제 및 이의 적용
CA3116884C (en) * 2018-10-18 2023-10-17 Regents Of The University Of Minnesota Bioink for 3d deposition
EP3872182A1 (en) * 2020-02-28 2021-09-01 Alganelle Recombinant microalgae able to produce peptides, polypeptides or proteins of collagen, elastin and their derivatives in the chloroplast of microalgae and associated method thereof
AU2021243961A1 (en) * 2020-03-22 2022-11-24 Collplant Ltd. Collagen-based formulations usable as soft tissue fillers and/or implants
CN111375088B (zh) * 2020-04-29 2022-06-14 陕西巨子生物技术有限公司 双层骨软骨组织修复支架及其制备方法
WO2021250186A1 (en) * 2020-06-11 2021-12-16 INSERM (Institut National de la Santé et de la Recherche Médicale) 3d bioprinting method for forming a cell specific tissue construct
KR102493622B1 (ko) * 2020-10-16 2023-01-31 주식회사 파이버엔텍 고강도 콜라겐 필라멘트의 제조방법
CN117881437A (zh) * 2021-03-18 2024-04-12 悉尼大学 胶原iv生物墨水
US12678541B2 (en) * 2021-10-07 2026-07-14 Technion Research & Development Foundation Limited Curable fibrinogen and uses thereof
US20250295791A1 (en) * 2021-10-27 2025-09-25 Collplant Ltd. Collagen-containing curable formulations
US20250026074A1 (en) * 2021-11-04 2025-01-23 The Trustees Of Princeton University 3d-printing engineered living materials
WO2023096401A1 (ko) * 2021-11-26 2023-06-01 주식회사 한국유니온 생명과학 아텔로콜라겐 기반 바이오 잉크 조성물 및 이를 이용하여 3차원 구조체를 제조하는 방법
CN114366856B (zh) * 2021-12-17 2022-11-18 同济大学 一种明胶胶原蛋白复合3d打印生物支架的方法
CN114259604B (zh) * 2021-12-17 2022-12-27 上海纳米技术及应用国家工程研究中心有限公司 一种3d打印促有序血管化的载药骨修复支架的制备方法及其产品和应用
EP4452604A4 (en) * 2021-12-22 2026-03-18 Univ Michigan Regents Acoustically Sensitive Bio-Inks for Extrusion-Based 3D Bio-Printing
JP7609096B2 (ja) * 2022-02-17 2025-01-07 Ｊｆｅエンジニアリング株式会社 ３次元プリンタおよび造形物の製造方法
CN114470305B (zh) * 2022-03-09 2023-01-03 南方科技大学 一种止血海绵及其制备方法
ES2994770T3 (en) * 2022-03-21 2025-01-31 Typeone Biomaterials S R L Bioink composition based on equine type i collagen, process for its preparation and its uses
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WO2023235832A1 (en) * 2022-06-02 2023-12-07 The Brigham And Women's Hospital, Inc. Molecularly cleavable bioink formulation
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CN115634317B (zh) * 2022-10-20 2023-09-08 上海市第六人民医院 一种用于神经损伤修复的胶原纤维复合膜
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Also Published As

Publication number Publication date
US20200179562A1 (en) 2020-06-11
US12115276B2 (en) 2024-10-15
EP3634512A4 (en) 2021-04-14
WO2018225076A8 (en) 2019-02-28
JP7659912B2 (ja) 2025-04-10
JP2020522357A (ja) 2020-07-30
WO2018225076A1 (en) 2018-12-13
JP7339889B2 (ja) 2023-09-06
JP2023116762A (ja) 2023-08-22
AU2018282131B2 (en) 2024-05-09
AU2018282131A1 (en) 2020-01-30
US20250032668A1 (en) 2025-01-30
EP3634512A1 (en) 2020-04-15

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