CA3060702A1 - Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration - Google Patents

Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration Download PDF

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Publication number
CA3060702A1
CA3060702A1 CA3060702A CA3060702A CA3060702A1 CA 3060702 A1 CA3060702 A1 CA 3060702A1 CA 3060702 A CA3060702 A CA 3060702A CA 3060702 A CA3060702 A CA 3060702A CA 3060702 A1 CA3060702 A1 CA 3060702A1
Authority
CA
Canada
Prior art keywords
pharmaceutical agent
antiarrhythmic
antiarrhythmic pharmaceutical
class
cases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3060702A
Other languages
English (en)
French (fr)
Inventor
Carlos Schuler
Rangachari Narasimhan
Luiz Belardinelli
Prashanti MADHAVAPEDDI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incarda Therapeutics Inc
Original Assignee
Madhavapeddi Prashanti
Incarda Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Madhavapeddi Prashanti, Incarda Therapeutics Inc filed Critical Madhavapeddi Prashanti
Publication of CA3060702A1 publication Critical patent/CA3060702A1/en
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4458Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Mechanical Engineering (AREA)
CA3060702A 2017-05-10 2018-05-10 Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration Pending CA3060702A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762504292P 2017-05-10 2017-05-10
US62/504,292 2017-05-10
PCT/US2018/032092 WO2018209107A1 (en) 2017-05-10 2018-05-10 Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration

Publications (1)

Publication Number Publication Date
CA3060702A1 true CA3060702A1 (en) 2018-11-15

Family

ID=64096874

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3060702A Pending CA3060702A1 (en) 2017-05-10 2018-05-10 Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration

Country Status (9)

Country Link
US (5) US10441537B2 (enExample)
EP (1) EP3621616A4 (enExample)
JP (2) JP2020519628A (enExample)
KR (1) KR20200003199A (enExample)
CN (1) CN110869018A (enExample)
AU (1) AU2018266199A1 (enExample)
CA (1) CA3060702A1 (enExample)
IL (1) IL270407B2 (enExample)
WO (1) WO2018209107A1 (enExample)

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* Cited by examiner, † Cited by third party
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JP2019509985A (ja) 2016-02-01 2019-04-11 インカーダ セラピューティクス, インコーポレイテッド 心房細動を含む心不整脈を管理するための吸入薬物療法との電子的監視の組み合せ
EP3768378B1 (en) 2018-03-22 2025-08-06 InCarda Therapeutics, Inc. A novel method to slow ventricular rate
US11007185B2 (en) * 2019-08-01 2021-05-18 Incarda Therapeutics, Inc. Antiarrhythmic formulation
IL321589A (en) * 2019-08-01 2025-08-01 Incarda Therapeutics Inc Antiarrhythmic formulation comprising a salt of flecainide
CN111595112B (zh) * 2020-05-26 2022-02-08 内蒙古铂贝曼科技有限公司 一种粉末磷脂的制备方法
JP2024502236A (ja) 2020-12-17 2024-01-18 インカーダ セラピューティクス, インコーポレイテッド 心房性不整脈を有する対象におけるカルディオバージョンの誘導のためのキットおよび方法
WO2023003593A1 (en) * 2021-07-20 2023-01-26 Kenox Pharmaceuticals, Inc. Pulmonary biguanide formulations

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AU2016256776B2 (en) 2009-03-18 2018-04-12 Incarda Therapeutics, Inc. Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration
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Also Published As

Publication number Publication date
KR20200003199A (ko) 2020-01-08
US20190083396A1 (en) 2019-03-21
US20200179279A1 (en) 2020-06-11
IL270407B1 (en) 2023-11-01
JP2023100743A (ja) 2023-07-19
JP2020519628A (ja) 2020-07-02
EP3621616A4 (en) 2021-01-13
WO2018209107A1 (en) 2018-11-15
AU2018266199A1 (en) 2019-11-07
EP3621616A1 (en) 2020-03-18
US10441537B2 (en) 2019-10-15
IL270407A (enExample) 2020-01-30
US20230092389A1 (en) 2023-03-23
US20200179278A1 (en) 2020-06-11
US20180325818A1 (en) 2018-11-15
CN110869018A (zh) 2020-03-06
IL270407B2 (en) 2024-03-01

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