CA3060143A1 - Novel psma-binding agents and uses thereof - Google Patents

Novel psma-binding agents and uses thereof Download PDF

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Publication number
CA3060143A1
CA3060143A1 CA3060143A CA3060143A CA3060143A1 CA 3060143 A1 CA3060143 A1 CA 3060143A1 CA 3060143 A CA3060143 A CA 3060143A CA 3060143 A CA3060143 A CA 3060143A CA 3060143 A1 CA3060143 A1 CA 3060143A1
Authority
CA
Canada
Prior art keywords
psma
acid
alb
compound
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3060143A
Other languages
English (en)
French (fr)
Inventor
Martina Benesova
Cristina Muller
Christoph UMBRICHT
Roger Schibli
Konstantin Zhernosekov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scherrer Paul Institut
ITM Isotope Technologies Munich SE
Original Assignee
Scherrer Paul Institut
ITM Isotope Technologies Munich SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2017/000717 external-priority patent/WO2018233798A1/en
Application filed by Scherrer Paul Institut, ITM Isotope Technologies Munich SE filed Critical Scherrer Paul Institut
Publication of CA3060143A1 publication Critical patent/CA3060143A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
    • A61B6/5211—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data
    • A61B6/5229—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image
    • A61B6/5235—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image combining images from the same or different ionising radiation imaging techniques, e.g. PET and CT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0495—Pretargeting
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3060143A 2017-05-24 2018-05-24 Novel psma-binding agents and uses thereof Pending CA3060143A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP17000891.6 2017-05-24
EP17000891 2017-05-24
EPPCT/EP2017/000717 2017-06-20
PCT/EP2017/000717 WO2018233798A1 (en) 2017-06-20 2017-06-20 Novel psma-binding agents and uses thereof
PCT/EP2018/063734 WO2018215627A1 (en) 2017-05-24 2018-05-24 Novel psma-binding agents and uses thereof

Publications (1)

Publication Number Publication Date
CA3060143A1 true CA3060143A1 (en) 2018-11-29

Family

ID=62200468

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3060143A Pending CA3060143A1 (en) 2017-05-24 2018-05-24 Novel psma-binding agents and uses thereof

Country Status (9)

Country Link
US (1) US11629201B2 (enExample)
EP (1) EP3630204A1 (enExample)
JP (1) JP7340459B2 (enExample)
KR (1) KR102843240B1 (enExample)
CN (1) CN110740757B (enExample)
AU (1) AU2018274184B2 (enExample)
CA (1) CA3060143A1 (enExample)
WO (1) WO2018215627A1 (enExample)
ZA (1) ZA201906832B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12472272B2 (en) 2019-04-17 2025-11-18 Provincial Health Services Authority Radiolabelled compounds for diagnosis or treatment of prostate-specific membrane antigen- expressing cancer

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102884167B1 (ko) * 2017-10-22 2025-11-12 프로빈셜 헬스 서비시즈 오쏘리티 전립선 특이적 막 항원-발현 암의 진단 또는 치료를 위한 신규한 라디오메탈-결합 화합물
WO2020112879A1 (en) * 2018-11-30 2020-06-04 Perkinelmer Health Sciences, Inc. Biological sample preparation using electric fields
WO2020150617A2 (en) * 2019-01-17 2020-07-23 Case Western Reserve University Peptide pet/spect probes specific to oncoproteins in tumor extracellula matrix
CN114423421A (zh) * 2019-05-24 2022-04-29 透明医药有限公司 Psma显像剂的制剂
KR20220024595A (ko) 2019-06-21 2022-03-03 프로빈셜 헬스 서비시즈 오쏘리티 전립선-특이적 막 항원을 표적으로 하는 방사성표지 화합물
TWI803688B (zh) * 2019-08-26 2023-06-01 行政院原子能委員會核能研究所 一種psma靶向放射診療藥物備製方法
KR102269315B1 (ko) 2019-10-24 2021-06-24 서울대학교산학협력단 전립선 암의 영상 또는 치료를 위한 동위원소 표지 화합물
CN113350531A (zh) * 2020-03-02 2021-09-07 上海核力星医药科技有限公司 前列腺特异性膜抗原结合配体偶联物及其应用
WO2022096103A1 (en) 2020-11-05 2022-05-12 ITM Isotopen Technologien München AG Combination of para-aminohippuric acid (pah) and radiolabeled complexes for treating cancer
WO2022111800A1 (en) 2020-11-25 2022-06-02 Itm Solucin Gmbh Stable formulations for radionuclide complexes
AU2022228911A1 (en) * 2021-03-04 2023-09-21 Kyoto University Compound and radioactive labeling compound
EP4341296A4 (en) * 2021-05-21 2025-07-30 Northstar Medical Tech Llc RADIOPHARMACEUTICAL PRODUCT TARGETING THE UROKINASE-TYPE PLASMINOGEN ACTIVATOR RECEPTOR
CN115745903B (zh) 2021-09-03 2024-07-23 晶核生物医药科技(南京)有限公司 一种肽脲素衍生物、含其的药物组合物及其应用
CN115806529A (zh) * 2021-09-15 2023-03-17 威智医药有限公司 Psma结合剂及其用途
EP4431503A1 (en) * 2021-11-10 2024-09-18 Suzhou Ruihe Medicine Technology Co., Ltd Ligand compound targeting psma antigen, and chelate and use thereof in diagnosis and treatment of prostate cancer
EP4436979A1 (en) 2021-11-26 2024-10-02 Full-Life Technologies HK Limited Cleavable radioligands for targeting cell surface receptors and uses thereof
JP2025507971A (ja) * 2022-03-04 2025-03-21 プロビンシャル・ヘルス・サービシーズ・オーソリティ 前立腺特異的膜抗原を標的とする放射性標識化合物
CN115010629B (zh) * 2022-06-07 2024-02-23 西南医科大学附属医院 前列腺特异性膜抗原抑制剂、其核素标记物及制法和应用
CA3260976A1 (en) * 2022-09-07 2024-03-14 3B Pharmaceuticals Gmbh PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA) LIGANDS AND ASSOCIATED USES
CN119855612A (zh) * 2022-09-09 2025-04-18 同宜医药（苏州）有限公司 放射性核素偶联药物及其药物组合物和应用
TW202426433A (zh) 2022-09-23 2024-07-01 瑞士商紐利迪姆股份公司 成纖維細胞活化蛋白（ｆａｐ）抑制劑、ｆａｐ結合物及其診斷與治療用途
US20240189460A1 (en) * 2022-09-23 2024-06-13 Nuclidium Ag High purity copper radiopharmaceutical compositions and diagnostic and therapeutic uses thereof
CN118496305A (zh) * 2023-02-16 2024-08-16 无锡诺宇医药科技有限公司 Psma靶向放射性药物及其合成和应用
CN121219017A (zh) * 2023-05-31 2025-12-26 辐联科技香港有限公司 缀合物及其用途
CN121219024A (zh) * 2023-05-31 2025-12-26 辐联科技香港有限公司 靶向细胞表面受体的放射性配体及其用途
CN120282805A (zh) 2023-07-31 2025-07-08 美国锔责任有限公司 [177Lu]镥-PSMA I&T组合物及其剂量测定、试剂盒、制备方法和使用方法
WO2025088147A1 (en) * 2023-10-27 2025-05-01 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Theranostic psma-targeting ligands for the diagnosis and treatment of psma-expressing cancers and their solid phase synthesis
WO2025218879A1 (en) 2024-04-15 2025-10-23 Itm Technologies Munich Se Stable formulations comprising 225-actinium labeled complexes and methods for preparing the same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0621973D0 (en) 2006-11-03 2006-12-13 Philogen Spa Binding molecules and uses thereof
CA2819850C (en) * 2010-12-06 2019-07-23 John W. Babich Psma-targeted dendrimers
JP5843338B2 (ja) 2011-08-05 2016-01-13 モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド 放射標識された前立腺特異的膜抗原阻害剤
HUE068833T2 (hu) 2011-08-17 2025-01-28 Merck & Cie Kmg Albumint megkötõ egységek folát konjugátjai
HUE061402T2 (hu) 2013-03-15 2023-06-28 Cancer Targeted Tech Llc 18F-jelölt PSMA-célzott PET képalkotó ágensek elõállításának módszerei és diagnosztikai módszerek velük
PE20211760A1 (es) * 2013-10-18 2021-09-07 Deutsches Krebsforsch Inhibidores marcados de antigeno prostatico especifico de membrana (psma) que comprenden grupos carboxilicos y una region de enlazador modificada, agentes formadores de imagenes y agentes farmaceuticos que los comprenden
EP2862857A1 (en) 2013-10-18 2015-04-22 Deutsches Krebsforschungszentrum Labeled inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
MX392700B (es) 2016-08-10 2025-03-11 Cancer Targeted Tech Llc Inhibidores de antígeno de la membrana específico para la próstata (psma) quelados.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12472272B2 (en) 2019-04-17 2025-11-18 Provincial Health Services Authority Radiolabelled compounds for diagnosis or treatment of prostate-specific membrane antigen- expressing cancer

Also Published As

Publication number Publication date
WO2018215627A1 (en) 2018-11-29
US20210009715A1 (en) 2021-01-14
EP3630204A1 (en) 2020-04-08
CN110740757A (zh) 2020-01-31
AU2018274184A1 (en) 2019-11-07
US11629201B2 (en) 2023-04-18
CN110740757B (zh) 2023-04-04
AU2018274184B2 (en) 2024-06-13
RU2019141963A (ru) 2021-06-24
JP7340459B2 (ja) 2023-09-07
RU2019141963A3 (enExample) 2021-09-22
ZA201906832B (en) 2024-02-28
JP2020520902A (ja) 2020-07-16
KR20200009091A (ko) 2020-01-29
KR102843240B1 (ko) 2025-08-05

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